Abstract: Objectives: In this work we address the need for the computation of quantitative global tumoral state indicators from oncological whole-body PET/computed tomography scans. The combination of such indicators with other oncological information such as tumor markers or biopsy results would prove useful in oncological decision-making scenarios.
Materials and methods: From an ordering of 100 breast cancer patients on the basis of oncological state through visual analysis by a consensus of nuclear medicine specialists, a set of numerical indicators computed from image analysis of the PET/computed tomography scan is presented, which attempts to summarize a patient’s oncological state in a quantitative manner taking into consideration the total tumor volume, aggressiveness, and spread.
Results: Results obtained by comparative analysis of the proposed indicators with respect to the experts’ evaluation show up to 87% Pearson’s correlation coefficient when providing expert-guided PET metabolic tumor volume segmentation and 64% correlation when using completely automatic image analysis techniques.
Conclusion: Global quantitative tumor information obtained by whole-body PET/CT image analysis can prove useful in clinical nuclear medicine settings and oncological decision-making scenarios. The completely automatic computation of such indicators would improve its impact as time efficiency and specialist independence would be achieved.

Abstract: OBJECTIVES:
The aim of the study was to address the need for quantifying the global cancer time evolution magnitude from a pair of time-consecutive positron emission tomography-computed tomography (PET-CT) scans. In particular, we focus on the computation of indicators using image-processing techniques that seek to model non-Hodgkin's lymphoma (NHL) progression or response severity.
MATERIALS AND METHODS:
A total of 89 pairs of time-consecutive PET-CT scans from NHL patients were stored in a nuclear medicine station for subsequent analysis. These were classified by a consensus of nuclear medicine physicians into progressions, partial responses, mixed responses, complete responses, and relapses. The cases of each group were ordered by magnitude following visual analysis. Thereafter, a set of quantitative indicators designed to model the cancer evolution magnitude within each group were computed using semiautomatic and automatic image-processing techniques. Performance evaluation of the proposed indicators was measured by a correlation analysis with the expert-based visual analysis.
RESULTS:
The set of proposed indicators achieved Pearson's correlation results in each group with respect to the expert-based visual analysis: 80.2% in progressions, 77.1% in partial response, 68.3% in mixed response, 88.5% in complete response, and 100% in relapse. In the progression and mixed response groups, the proposed indicators outperformed the common indicators used in clinical practice [changes in metabolic tumor volume, mean, maximum, peak standardized uptake value (SUV mean, SUV max, SUV peak), and total lesion glycolysis] by more than 40%.
CONCLUSION:
Computing global indicators of NHL response using PET-CT imaging techniques offers a strong correlation with the associated expert-based visual analysis, motivating the future incorporation of such quantitative and highly observer-independent indicators in oncological decision making or treatment response evaluation scenarios.

Abstract: In this study, the authors propose the spatial codification of label predictions within the multi-scale stacked sequential learning (MSSL) framework, a successful learning scheme to deal with non-independent identically distributed data entries. After providing a motivation for this objective, they describe its theoretical framework based on the introduction of the blurred shape model as a smart descriptor to codify the spatial distribution of the predicted labels and define the new extended feature set for the second stacked classifier. They then particularise this scheme to be applied in volume segmentation applications. Finally, they test the implementation of the proposed framework in two medical volume segmentation datasets, obtaining significant performance improvements (with a 95% of confidence) in comparison to standard Adaboost classifier and classical MSSL approaches.

Abstract: In this work we present a comprehensive computational framework to help in the clinical assessment of cancer response from a pair of time consecutive oncological PET-CT scans. In this scenario, the design and implementation of a supervised machine learning system to predict and quantify cancer progression or response conditions by introducing a novel feature set that models the underlying clinical context is described. Performance results in 100 clinical cases (corresponding to 200 whole body PET-CT scans) in comparing expert-based visual analysis and classifier decision making show up to 70% accuracy within a completely automatic pipeline and 90% accuracy when providing the system with expert-guided PET tumor segmentation masks.

Abstract: Semantic image retrieval from large amounts of egocentric visual data requires to leverage powerful techniques for filling in the semantic gap. This paper introduces LEMoRe, a Lifelog Engine for Moments Retrieval, developed in the context of the Lifelog Semantic Access Task (LSAT) of the the NTCIR-12 challenge and discusses its performance variation on different trials. LEMoRe integrates classical image descriptors with high-level semantic concepts extracted by Convolutional Neural Networks (CNN), powered by a graphic user interface that uses natural language processing. Although this is just a first attempt towards interactive image retrieval from large egocentric datasets and there is a large room for improvement of the system components and the user interface, the structure of the system itself and the way the single components cooperate are very promising.

Abstract: We consider a quantum system that is being continuously monitored, giving rise to a measurement signal. From such a stream of data, information needs to be inferred about the underlying system's dynamics. Here we focus on hypothesis testing problems and put forward the usage of sequential strategies where the signal is analyzed in real time, allowing the experiment to be concluded as soon as the underlying hypothesis can be identified with a certified prescribed success probability. We analyze the performance of sequential tests by studying the stopping-time behavior, showing a considerable advantage over currently-used strategies based on a fixed predetermined measurement time.

Abstract: Non-rigid object detection is a challenging an open research problem in computer vision. It is a critical part in many applications such as image search, surveillance, human-computer interaction or image auto-annotation. Most successful approaches to non-rigid object detection make use of part-based models. In particular, Conditional Random Fields (CRF) have been successfully embedded into a discriminative parts-based model framework due to its effectiveness for learning and inference (usually based on a tree structure). However, CRF-based approaches do not incorporate global constraints and only model pairwise interactions. This is especially important when modeling object classes that may have complex parts interactions (e.g. facial features or body articulations), because neglecting them yields an oversimplified model with suboptimal performance. To overcome this limitation, this paper proposes a novel hierarchical CRF (HCRF). The main contribution is to build a hierarchy of part combinations by extending the label set to a hierarchy of product label spaces. In order to keep the inference computation tractable, we propose an effective method to reduce the new label set. We test our method on two applications: facial feature detection on the Multi-PIE database and human pose estimation on the Buffy dataset.

Abstract: Longitudinal kinetics (LOKI) of the arterial wall consists of the shearing motion of the intima-media complex over the adventitia layer in the direction parallel to the blood flow during the cardiac cycle. The aim of this study was to investigate the local variability of LOKI amplitude along the length of the vessel. By use of a previously validated motion-estimation framework, 35 in vivo longitudinal B-mode ultrasound cine loops of healthy common carotid arteries were analyzed. Results indicated that LOKI amplitude is progressively attenuated along the length of the artery, as it is larger in regions located on the proximal side of the image (i.e., toward the heart) and smaller in regions located on the distal side of the image (i.e., toward the head), with an average attenuation coefficient of -2.5 ± 2.0%/mm. Reported for the first time in this study, this phenomenon is likely to be of great importance in improving understanding of atherosclerosis mechanisms, and has the potential to be a novel index of arterial stiffness.