Abstract: Quantification of tumor heterogeneity is essential to better understand cancer progression and to adapt therapeutic treatments to patient specificities. Bioinformatic tools to assess the different cell populations from single-omic datasets as bulk transcriptome or methylome samples have been recently developed, including reference-based and reference-free methods. Improved methods using multi-omic datasets are yet to be developed in the future and the community would need systematic tools to perform a comparative evaluation of these algorithms on controlled data.

Abstract: Purpose: Atheromatic plaque progression is affected, among others phenomena, by biomechanical, biochemical, and physiological factors. In this paper, the authors introduce a novel framework able to provide both morphological (vessel radius, plaque thickness, and type) and biomechanical (wall shear stress and Von Mises stress) indices of coronary arteries.Methods: First, the approach reconstructs the three-dimensional morphology of the vessel from intravascular ultrasound (IVUS) and Angiographic sequences, requiring minimal user interaction. Then, a computational pipeline allows to automatically assess fluid-dynamic and mechanical indices. Ten coronary arteries are analyzed illustrating the capabilities of the tool and confirming previous technical and clinical observations.Results: The relations between the arterial indices obtained by IVUS measurement and simulations have been quantitatively analyzed along the whole surface of the artery, extending the analysis of the coronary arteries shown in previous state of the art studies. Additionally, for the first time in the literature, the framework allows the computation of the membrane stresses using a simplified mechanical model of the arterial wall.Conclusions: Circumferentially (within a given frame), statistical analysis shows an inverse relation between the wall shear stress and the plaque thickness. At the global level (comparing a frame within the entire vessel), it is observed that heavy plaque accumulations are in general calcified and are located in the areas of the vessel having high wall shear stress. Finally, in their experiments the inverse proportionality between fluid and structural stresses is observed.

Abstract: PURPOSE:
Personalized computational simulations of the heart could open up new improved approaches to diagnosis and surgery assistance systems. While it is fully recognized that myocardial fiber orientation is central for the construction of realistic computational models of cardiac electromechanics, the role of its overall architecture and connectivity remains unclear. Morphological studies show that the distribution of cardiac muscular fibers at the basal ring connects epicardium and endocardium. However, computational models simplify their distribution and disregard the basal loop. This work explores the influence in computational simulations of fiber distribution at different short-axis cuts.
METHODS:
We have used a highly parallelized computational solver to test different fiber models of ventricular muscular connectivity. We have considered two rule-based mathematical models and an own-designed method preserving basal connectivity as observed in experimental data. Simulated cardiac functional scores (rotation, torsion and longitudinal shortening) were compared to experimental healthy ranges using generalized models (rotation) and Mahalanobis distances (shortening, torsion).
RESULTS:
The probability of rotation was significantly lower for ruled-based models [95% CI (0.13, 0.20)] in comparison with experimental data [95% CI (0.23, 0.31)]. The Mahalanobis distance for experimental data was in the edge of the region enclosing 99% of the healthy population.
CONCLUSIONS:
Cardiac electromechanical simulations of the heart with fibers extracted from experimental data produce functional scores closer to healthy ranges than rule-based models disregarding architecture connectivity.

Abstract: PURPOSE:
In this article, the authors studied the feasibility of estimating regional mechanical properties in cerebral aneurysms, integrating information extracted from imaging and physiological data with generic computational models of the arterial wall behavior.
METHODS:
A data assimilation framework was developed to incorporate patient-specific geometries into a given biomechanical model, whereas wall motion estimates were obtained from applying registration techniques to a pair of simulated MR images and guided the mechanical parameter estimation. A simple incompressible linear and isotropic Hookean model coupled with computational fluid-dynamics was employed as a first approximation for computational purposes. Additionally, an automatic clustering technique was developed to reduce the number of parameters to assimilate at the optimization stage and it considerably accelerated the convergence of the simulations. Several in silico experiments were designed to assess the influence of aneurysm geometrical characteristics and the accuracy of wall motion estimates on the mechanical property estimates. Hence, the proposed methodology was applied to six real cerebral aneurysms and tested against a varying number of regions with different elasticity, different mesh discretization, imaging resolution, and registration configurations.
RESULTS:
Several in silico experiments were conducted to investigate the feasibility of the proposed workflow, results found suggesting that the estimation of the mechanical properties was mainly influenced by the image spatial resolution and the chosen registration configuration. According to the in silico experiments, the minimal spatial resolution needed to extract wall pulsation measurements with enough accuracy to guide the proposed data assimilation framework was of 0.1 mm.
CONCLUSIONS:
Current routine imaging modalities do not have such a high spatial resolution and therefore the proposed data assimilation framework cannot currently be used on in vivo data to reliably estimate regional properties in cerebral aneurysms. Besides, it was observed that the incorporation of fluid-structure interaction in a biomechanical model with linear and isotropic material properties did not have a substantial influence in the final results.

Abstract: Purpose of review
Atherosclerosis is the leading cause of cardiovascular disease (CVD) and stroke. Typically, atherosclerotic calcium is found during the mature stage of the atherosclerosis disease. It is therefore often a challenge to identify and quantify the calcium. This is due to the presence of multiple components of plaque buildup in the arterial walls. The American College of Cardiology/American Heart Association guidelines point to the importance of calcium in the coronary and carotid arteries and further recommend its quantification for the prevention of heart disease. It is therefore essential to stratify the CVD risk of the patient into low- and high-risk bins.
Recent finding
Calcium formation in the artery walls is multifocal in nature with sizes at the micrometer level. Thus, its detection requires high-resolution imaging. Clinical experience has shown that even though optical coherence tomography offers better resolution, intravascular ultrasound still remains an important imaging modality for coronary wall imaging. For a computer-based analysis system to be complete, it must be scientifically and clinically validated. This study presents a state-of-the-art review (condensation of 152 publications after examining 200 articles) covering the methods for calcium detection and its quantification for coronary and carotid arteries, the pros and cons of these methods, and the risk stratification strategies. The review also presents different kinds of statistical models and gold standard solutions for the evaluation of software systems useful for calcium detection and quantification. Finally, the review concludes with a possible vision for designing the next-generation system for better clinical outcomes.

Abstract: Psychophysical experiments were conducted to assess unique hues on a CRT display for a large sample of colour-normal observers (n 1⁄4 185). These data were then used to evaluate the most commonly used colour appear- ance model, CIECAM02, by transforming the CIEXYZ tris- timulus values of the unique hues to the CIECAM02 colour appearance attributes, lightness, chroma and hue angle. We report two findings: (1) the hue angles derived from our unique hue data are inconsistent with the commonly used Natural Color System hues that are incorporated in the CIECAM02 model. We argue that our predicted unique hue angles (derived from our large dataset) provide a more reliable standard for colour management applications when the precise specification of these salient colours is im- portant. (2) We test hue uniformity for CIECAM02 in all four unique hues and show significant disagreements for all hues, except for unique red which seems to be invariant under lightness changes. Our dataset is useful to improve the CIECAM02 model as it provides reliable data for benchmarking.

Abstract: Psychological evidence has emphasized the importance of affective behaviour understanding due to its high impact in nowadays interaction humans and computers. All
type of affective and behavioural patterns such as gestures, emotions and mental
states are highly displayed through the face, head and body. Therefore, this thesis is
focused to analyse affective behaviours on head and face. To this end, head and facial
movements are encoded by using appearance based tracking methods. Specifically,
a wise combination of deformable models captures rigid and non-rigid movements of
different kinematics; 3D head pose, eyebrows, mouth, eyelids and irises are taken into
account as basis for extracting features from databases of video sequences. This approach combines the strengths of adaptive appearance models, optimization methods
and backtracking techniques.
For about thirty years, computer sciences have addressed the investigation on
human emotions to the automatic recognition of six prototypic emotions suggested
by Darwin and systematized by Paul Ekman in the seventies. The Facial Action
Coding System (FACS) which uses discrete movements of the face (called Action
units or AUs) to code the six facial emotions named anger, disgust, fear, happy-Joy,
sadness and surprise. However, human emotions are much complex patterns that
have not received the same attention from computer scientists.
Simon Baron-Cohen proposed a new taxonomy of emotions and mental states
without a system coding of the facial actions. These 426 affective behaviours are
more challenging for the understanding of human emotions. Beyond of classically
classifying the six basic facial expressions, more subtle gestures, facial actions and
spontaneous emotions are considered here. By assessing confidence on the recognition
results, exploring spatial and temporal relationships of the features, some methods are
combined and enhanced for developing new taxonomy of expressions and emotions.
The objective of this dissertation is to develop a computer vision system, including both facial feature extraction, expression recognition and emotion understanding
by building a bottom-up reasoning process. Building a detailed taxonomy of human
affective behaviours is an interesting challenge for head-face-based image analysis
methods. In this paper, we exploit the strengths of Canonical Correlation Analysis
(CCA) to enhance an on-line head-face tracker. A relationship between head pose and
local facial movements is studied according to their cognitive interpretation on affective expressions and emotions. Active Shape Models are synthesized for AAMs based
on CCA-regression. Head pose and facial actions are fused into a maximally correlated space in order to assess expressiveness, confidence and classification in a CBR system. The CBR solutions are also correlated to the cognitive features, which allow
avoiding exhaustive search when recognizing new head-face features. Subsequently,
Support Vector Machines (SVMs) and Bayesian Networks are applied for learning the
spatial relationships of facial expressions. Similarly, the temporal evolution of facial
expressions, emotion and mental states are analysed based on Factorized Dynamic
Bayesian Networks (FaDBN).
As results, the bottom-up system recognizes six facial expressions, six basic emotions and six mental states, plus enhancing this categorization with confidence assessment at each level, intensity of expressions and a complete taxonomy