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	Author	Joan Marc Llargues Asensio; Juan Peralta; Raul Arrabales; Manuel Gonzalez Bedia; Paulo Cortez; Antonio Lopez
	Title	Artificial Intelligence Approaches for the Generation and Assessment of Believable Human-Like Behaviour in Virtual Characters			Type	Journal Article
	Year	2014	Publication	Expert Systems With Applications	Abbreviated Journal	EXSY
	Volume	41	Issue	16	Pages	7281–7290
	Keywords	Turing test; Human-like behaviour; Believability; Non-player characters; Cognitive architectures; Genetic algorithm; Artificial neural networks
	Abstract	Having artificial agents to autonomously produce human-like behaviour is one of the most ambitious original goals of Artificial Intelligence (AI) and remains an open problem nowadays. The imitation game originally proposed by Turing constitute a very effective method to prove the indistinguishability of an artificial agent. The behaviour of an agent is said to be indistinguishable from that of a human when observers (the so-called judges in the Turing test) cannot tell apart humans and non-human agents. Different environments, testing protocols, scopes and problem domains can be established to develop limited versions or variants of the original Turing test. In this paper we use a specific version of the Turing test, based on the international BotPrize competition, built in a First-Person Shooter video game, where both human players and non-player characters interact in complex virtual environments. Based on our past experience both in the BotPrize competition and other robotics and computer game AI applications we have developed three new more advanced controllers for believable agents: two based on a combination of the CERA–CRANIUM and SOAR cognitive architectures and other based on ADANN, a system for the automatic evolution and adaptation of artificial neural networks. These two new agents have been put to the test jointly with CCBot3, the winner of BotPrize 2010 competition (Arrabales et al., 2012), and have showed a significant improvement in the humanness ratio. Additionally, we have confronted all these bots to both First-person believability assessment (BotPrize original judging protocol) and Third-person believability assessment, demonstrating that the active involvement of the judge has a great impact in the recognition of human-like behaviour.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	ADAS; 600.055; 600.057; 600.076			Approved	no
	Call Number	Admin @ si @ LPA2014			Serial	2500
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	Author	Jorge Bernal
	Title	Polyp Localization and Segmentation in Colonoscopy Images by Means of a Model of Appearance for Polyps			Type	Journal Article
	Year	2014	Publication	Electronic Letters on Computer Vision and Image Analysis	Abbreviated Journal	ELCVIA
	Volume	13	Issue	2	Pages	9-10
	Keywords	Colonoscopy; polyp localization; polyp segmentation; Eye-tracking
	Abstract	Colorectal cancer is the fourth most common cause of cancer death worldwide and its survival rate depends on the stage in which it is detected on hence the necessity for an early colon screening. There are several screening techniques but colonoscopy is still nowadays the gold standard, although it has some drawbacks such as the miss rate. Our contribution, in the field of intelligent systems for colonoscopy, aims at providing a polyp localization and a polyp segmentation system based on a model of appearance for polyps. To develop both methods we define a model of appearance for polyps, which describes a polyp as enclosed by intensity valleys. The novelty of our contribution resides on the fact that we include in our model aspects of the image formation and we also consider the presence of other elements from the endoluminal scene such as specular highlights and blood vessels, which have an impact on the performance of our methods. In order to develop our polyp localization method we accumulate valley information in order to generate energy maps, which are also used to guide the polyp segmentation. Our methods achieve promising results in polyp localization and segmentation. As we want to explore the usability of our methods we present a comparative analysis between physicians fixations obtained via an eye tracking device and our polyp localization method. The results show that our method is indistinguishable to novice physicians although it is far from expert physicians.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor	Alicia Fornes; Volkmar Frinken
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	MV			Approved	no
	Call Number	Admin @ si @ Ber2014			Serial	2487
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	Author	Ariel Amato
	Title	Moving cast shadow detection			Type	Journal Article
	Year	2014	Publication	Electronic letters on computer vision and image analysis	Abbreviated Journal	ELCVIA
	Volume	13	Issue	2	Pages	70-71
	Keywords
	Abstract	Motion perception is an amazing innate ability of the creatures on the planet. This adroitness entails a functional advantage that enables species to compete better in the wild. The motion perception ability is usually employed at different levels, allowing from the simplest interaction with the ’physis’ up to the most transcendental survival tasks. Among the five classical perception system , vision is the most widely used in the motion perception field. Millions years of evolution have led to a highly specialized visual system in humans, which is characterized by a tremendous accuracy as well as an extraordinary robustness. Although humans and an immense diversity of species can distinguish moving object with a seeming simplicity, it has proven to be a difficult and non trivial problem from a computational perspective. In the field of Computer Vision, the detection of moving objects is a challenging and fundamental research area. This can be referred to as the ’origin’ of vast and numerous vision-based research sub-areas. Nevertheless, from the bottom to the top of this hierarchical analysis, the foundations still relies on when and where motion has occurred in an image. Pixels corresponding to moving objects in image sequences can be identified by measuring changes in their values. However, a pixel’s value (representing a combination of color and brightness) could also vary due to other factors such as: variation in scene illumination, camera noise and nonlinear sensor responses among others. The challenge lies in detecting if the changes in pixels’ value are caused by a genuine object movement or not. An additional challenging aspect in motion detection is represented by moving cast shadows. The paradox arises because a moving object and its cast shadow share similar motion patterns. However, a moving cast shadow is not a moving object. In fact, a shadow represents a photometric illumination effect caused by the relative position of the object with respect to the light sources. Shadow detection methods are mainly divided in two domains depending on the application field. One normally consists of static images where shadows are casted by static objects, whereas the second one is referred to image sequences where shadows are casted by moving objects. For the first case, shadows can provide additional geometric and semantic cues about shape and position of its casting object as well as the localization of the light source. Although the previous information can be extracted from static images as well as video sequences, the main focus in the second area is usually change detection, scene matching or surveillance. In this context, a shadow can severely affect with the analysis and interpretation of the scene. The work done in the thesis is focused on the second case, thus it addresses the problem of detection and removal of moving cast shadows in video sequences in order to enhance the detection of moving object.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	ISE			Approved	no
	Call Number	Admin @ si @ Ama2014			Serial	2870
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	Author	C. Alejandro Parraga; Jordi Roca; Dimosthenis Karatzas; Sophie Wuerger
	Title	Limitations of visual gamma corrections in LCD displays			Type	Journal Article
	Year	2014	Publication	Displays	Abbreviated Journal	Dis
	Volume	35	Issue	5	Pages	227–239
	Keywords	Display calibration; Psychophysics; Perceptual; Visual gamma correction; Luminance matching; Observer-based calibration
	Abstract	A method for estimating the non-linear gamma transfer function of liquid–crystal displays (LCDs) without the need of a photometric measurement device was described by Xiao et al. (2011) [1]. It relies on observer’s judgments of visual luminance by presenting eight half-tone patterns with luminances from 1/9 to 8/9 of the maximum value of each colour channel. These half-tone patterns were distributed over the screen both over the vertical and horizontal viewing axes. We conducted a series of photometric and psychophysical measurements (consisting in the simultaneous presentation of half-tone patterns in each trial) to evaluate whether the angular dependency of the light generated by three different LCD technologies would bias the results of these gamma transfer function estimations. Our results show that there are significant differences between the gamma transfer functions measured and produced by observers at different viewing angles. We suggest appropriate modifications to the Xiao et al. paradigm to counterbalance these artefacts which also have the advantage of shortening the amount of time spent in collecting the psychophysical measurements.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	CIC; DAG; 600.052; 600.077; 600.074			Approved	no
	Call Number	Admin @ si @ PRK2014			Serial	2511
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	Author	Juan Ramon Terven Salinas; Joaquin Salas; Bogdan Raducanu
	Title	New Opportunities for Computer Vision-Based Assistive Technology Systems for the Visually Impaired			Type	Journal Article
	Year	2014	Publication	Computer	Abbreviated Journal	COMP
	Volume	47	Issue	4	Pages	52-58
	Keywords
	Abstract	Computing advances and increased smartphone use gives technology system designers greater flexibility in exploiting computer vision to support visually impaired users. Understanding these users' needs will certainly provide insight for the development of improved usability of computing devices.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0018-9162	ISBN		Medium
	Area		Expedition		Conference
	Notes	LAMP;			Approved	no
	Call Number	Admin @ si @ TSR2014a			Serial	2317
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	Author	Antonio Clavelli; Dimosthenis Karatzas; Josep Llados; Mario Ferraro; Giuseppe Boccignone
	Title	Modelling task-dependent eye guidance to objects in pictures			Type	Journal Article
	Year	2014	Publication	Cognitive Computation	Abbreviated Journal	CoCom
	Volume	6	Issue	3	Pages	558-584
	Keywords	Visual attention; Gaze guidance; Value; Payoff; Stochastic fixation prediction
	Abstract	5Y Impact Factor: 1.14 / 3rd (Computer Science, Artificial Intelligence) We introduce a model of attentional eye guidance based on the rationale that the deployment of gaze is to be considered in the context of a general action-perception loop relying on two strictly intertwined processes: sensory processing, depending on current gaze position, identifies sources of information that are most valuable under the given task; motor processing links such information with the oculomotor act by sampling the next gaze position and thus performing the gaze shift. In such a framework, the choice of where to look next is task-dependent and oriented to classes of objects embedded within pictures of complex scenes. The dependence on task is taken into account by exploiting the value and the payoff of gazing at certain image patches or proto-objects that provide a sparse representation of the scene objects. The different levels of the action-perception loop are represented in probabilistic form and eventually give rise to a stochastic process that generates the gaze sequence. This way the model also accounts for statistical properties of gaze shifts such as individual scan path variability. Results of the simulations are compared either with experimental data derived from publicly available datasets and from our own experiments.
	Address
	Corporate Author				Thesis
	Publisher	Springer US	Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	1866-9956	ISBN		Medium
	Area		Expedition		Conference
	Notes	DAG; 600.056; 600.045; 605.203; 601.212; 600.077			Approved	no
	Call Number	Admin @ si @ CKL2014			Serial	2419
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	Author	Simone Balocco; Carlo Gatta; Francesco Ciompi; A. Wahle; Petia Radeva; S. Carlier; G. Unal; E. Sanidas; J. Mauri; X. Carillo; T. Kovarnik; C. Wang; H. Chen; T. P. Exarchos; D. I. Fotiadis; F. Destrempes; G. Cloutier; Oriol Pujol; Marina Alberti; E. G. Mendizabal-Ruiz; M. Rivera; T. Aksoy; R. W. Downe; I. A. Kakadiaris
	Title	Standardized evaluation methodology and reference database for evaluating IVUS image segmentation			Type	Journal Article
	Year	2014	Publication	Computerized Medical Imaging and Graphics	Abbreviated Journal	CMIG
	Volume	38	Issue	2	Pages	70-90
	Keywords	IVUS (intravascular ultrasound); Evaluation framework; Algorithm comparison; Image segmentation
	Abstract	This paper describes an evaluation framework that allows a standardized and quantitative comparison of IVUS lumen and media segmentation algorithms. This framework has been introduced at the MICCAI 2011 Computing and Visualization for (Intra)Vascular Imaging (CVII) workshop, comparing the results of eight teams that participated. We describe the available data-base comprising of multi-center, multi-vendor and multi-frequency IVUS datasets, their acquisition, the creation of the reference standard and the evaluation measures. The approaches address segmentation of the lumen, the media, or both borders; semi- or fully-automatic operation; and 2-D vs. 3-D methodology. Three performance measures for quantitative analysis have been proposed. The results of the evaluation indicate that segmentation of the vessel lumen and media is possible with an accuracy that is comparable to manual annotation when semi-automatic methods are used, as well as encouraging results can be obtained also in case of fully-automatic segmentation. The analysis performed in this paper also highlights the challenges in IVUS segmentation that remains to be solved.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	MILAB; LAMP; HuPBA; 600.046; 600.063; 600.079			Approved	no
	Call Number	Admin @ si @ BGC2013			Serial	2314
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	Author	Simeon Petkov; Xavier Carrillo; Petia Radeva; Carlo Gatta
	Title	Diaphragm border detection in coronary X-ray angiographies: New method and applications			Type	Journal Article
	Year	2014	Publication	Computerized Medical Imaging and Graphics	Abbreviated Journal	CMIG
	Volume	38	Issue	4	Pages	296-305
	Keywords
	Abstract	X-ray angiography is widely used in cardiac disease diagnosis during or prior to intravascular interventions. The diaphragm motion and the heart beating induce gray-level changes, which are one of the main obstacles in quantitative analysis of myocardial perfusion. In this paper we focus on detecting the diaphragm border in both single images or whole X-ray angiography sequences. We show that the proposed method outperforms state of the art approaches. We extend a previous publicly available data set, adding new ground truth data. We also compose another set of more challenging images, thus having two separate data sets of increasing difficulty. Finally, we show three applications of our method: (1) a strategy to reduce false positives in vessel enhanced images; (2) a digital diaphragm removal algorithm; (3) an improvement in Myocardial Blush Grade semi-automatic estimation.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	MILAB; LAMP; 600.079			Approved	no
	Call Number	Admin @ si @ PCR2014			Serial	2468
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	Author	Frederic Sampedro; Sergio Escalera; Anna Domenech; Ignasi Carrio
	Title	A computational framework for cancer response assessment based on oncological PET-CT scans			Type	Journal Article
	Year	2014	Publication	Computers in Biology and Medicine	Abbreviated Journal	CBM
	Volume	55	Issue		Pages	92–99
	Keywords	Computer aided diagnosis; Nuclear medicine; Machine learning; Image processing; Quantitative analysis
	Abstract	In this work we present a comprehensive computational framework to help in the clinical assessment of cancer response from a pair of time consecutive oncological PET-CT scans. In this scenario, the design and implementation of a supervised machine learning system to predict and quantify cancer progression or response conditions by introducing a novel feature set that models the underlying clinical context is described. Performance results in 100 clinical cases (corresponding to 200 whole body PET-CT scans) in comparing expert-based visual analysis and classifier decision making show up to 70% accuracy within a completely automatic pipeline and 90% accuracy when providing the system with expert-guided PET tumor segmentation masks.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	HuPBA;MILAB			Approved	no
	Call Number	Admin @ si @ SED2014			Serial	2606
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	Author	Josep Llados; Marçal Rusiñol
	Title	Graphics Recognition Techniques			Type	Book Chapter
	Year	2014	Publication	Handbook of Document Image Processing and Recognition	Abbreviated Journal
	Volume	D	Issue		Pages	489-521
	Keywords	Dimension recognition; Graphics recognition; Graphic-rich documents; Polygonal approximation; Raster-to-vector conversion; Texture-based primitive extraction; Text-graphics separation
	Abstract	This chapter describes the most relevant approaches for the analysis of graphical documents. The graphics recognition pipeline can be splitted into three tasks. The low level or lexical task extracts the basic units composing the document. The syntactic level is focused on the structure, i.e., how graphical entities are constructed, and involves the location and classification of the symbols present in the document. The third level is a functional or semantic level, i.e., it models what the graphical symbols do and what they mean in the context where they appear. This chapter covers the lexical level, while the next two chapters are devoted to the syntactic and semantic level, respectively. The main problems reviewed in this chapter are raster-to-vector conversion (vectorization algorithms) and the separation of text and graphics components. The research and industrial communities have provided standard methods achieving reasonable performance levels. Hence, graphics recognition techniques can be considered to be in a mature state from a scientific point of view. Additionally this chapter provides insights on some related problems, namely, the extraction and recognition of dimensions in engineering drawings, and the recognition of hatched and tiled patterns. Both problems are usually associated, even integrated, in the vectorization process.
	Address
	Corporate Author				Thesis
	Publisher	Springer London	Place of Publication		Editor	D. Doermann; K. Tombre
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN	978-0-85729-858-4	Medium
	Area		Expedition		Conference
	Notes	DAG; 600.077			Approved	no
	Call Number	Admin @ si @ LlR2014			Serial	2380
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	Author	Salvatore Tabbone; Oriol Ramos Terrades
	Title	An Overview of Symbol Recognition			Type	Book Chapter
	Year	2014	Publication	Handbook of Document Image Processing and Recognition	Abbreviated Journal
	Volume	D	Issue		Pages	523-551
	Keywords	Pattern recognition; Shape descriptors; Structural descriptors; Symbolrecognition; Symbol spotting
	Abstract	According to the Cambridge Dictionaries Online, a symbol is a sign, shape, or object that is used to represent something else. Symbol recognition is a subfield of general pattern recognition problems that focuses on identifying, detecting, and recognizing symbols in technical drawings, maps, or miscellaneous documents such as logos and musical scores. This chapter aims at providing the reader an overview of the different existing ways of describing and recognizing symbols and how the field has evolved to attain a certain degree of maturity.
	Address
	Corporate Author				Thesis
	Publisher	Springer London	Place of Publication		Editor	D. Doermann; K. Tombre
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN	978-0-85729-858-4	Medium
	Area		Expedition		Conference
	Notes	DAG; 600.077			Approved	no
	Call Number	Admin @ si @ TaT2014			Serial	2489
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	Author	Anjan Dutta; Josep Llados; Horst Bunke; Umapada Pal
	Title	A Product Graph Based Method for Dual Subgraph Matching Applied to Symbol Spotting			Type	Book Chapter
	Year	2014	Publication	Graphics Recognition. Current Trends and Challenges	Abbreviated Journal
	Volume	8746	Issue		Pages	7-11
	Keywords	Product graph; Dual edge graph; Subgraph matching; Random walks; Graph kernel
	Abstract	Product graph has been shown as a way for matching subgraphs. This paper reports the extension of the product graph methodology for subgraph matching applied to symbol spotting in graphical documents. Here we focus on the two major limitations of the previous version of the algorithm: (1) spurious nodes and edges in the graph representation and (2) inefficient node and edge attributes. To deal with noisy information of vectorized graphical documents, we consider a dual edge graph representation on the original graph representing the graphical information and the product graph is computed between the dual edge graphs of the pattern graph and the target graph. The dual edge graph with redundant edges is helpful for efficient and tolerating encoding of the structural information of the graphical documents. The adjacency matrix of the product graph locates the pair of similar edges of two operand graphs and exponentiating the adjacency matrix finds similar random walks of greater lengths. Nodes joining similar random walks between two graphs are found by combining different weighted exponentials of adjacency matrices. An experimental investigation reveals that the recall obtained by this approach is quite encouraging.
	Address
	Corporate Author				Thesis
	Publisher	Springer Berlin Heidelberg	Place of Publication		Editor	Bart Lamiroy; Jean-Marc Ogier
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title	LNCS
	Series Volume		Series Issue		Edition
	ISSN	0302-9743	ISBN	978-3-662-44853-3	Medium
	Area		Expedition		Conference
	Notes	DAG; 600.077			Approved	no
	Call Number	Admin @ si @ DLB2014			Serial	2698
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	Author	David Geronimo; Antonio Lopez
	Title	Vision-based Pedestrian Protection Systems for Intelligent Vehicles			Type	Book Whole
	Year	2014	Publication	SpringerBriefs in Computer Science	Abbreviated Journal
	Volume		Issue		Pages	1-114
	Keywords	Computer Vision; Driver Assistance Systems; Intelligent Vehicles; Pedestrian Detection; Vulnerable Road Users
	Abstract	Pedestrian Protection Systems (PPSs) are on-board systems aimed at detecting and tracking people in the surroundings of a vehicle in order to avoid potentially dangerous situations. These systems, together with other Advanced Driver Assistance Systems (ADAS) such as lane departure warning or adaptive cruise control, are one of the most promising ways to improve traffic safety. By the use of computer vision, cameras working either in the visible or infra-red spectra have been demonstrated as a reliable sensor to perform this task. Nevertheless, the variability of human’s appearance, not only in terms of clothing and sizes but also as a result of their dynamic shape, makes pedestrians one of the most complex classes even for computer vision. Moreover, the unstructured changing and unpredictable environment in which such on-board systems must work makes detection a difficult task to be carried out with the demanded robustness. In this brief, the state of the art in PPSs is introduced through the review of the most relevant papers of the last decade. A common computational architecture is presented as a framework to organize each method according to its main contribution. More than 300 papers are referenced, most of them addressing pedestrian detection and others corresponding to the descriptors (features), pedestrian models, and learning machines used. In addition, an overview of topics such as real-time aspects, systems benchmarking and future challenges of this research area are presented.
	Address
	Corporate Author				Thesis
	Publisher	Springer Briefs in Computer Vision	Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN	978-1-4614-7986-4	Medium
	Area		Expedition		Conference
	Notes	ADAS; 600.076			Approved	no
	Call Number	GeL2014			Serial	2325
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	Author	Ariel Amato; Ivan Huerta; Mikhail Mozerov; Xavier Roca; Jordi Gonzalez
	Title	Moving Cast Shadows Detection Methods for Video Surveillance Applications			Type	Book Chapter
	Year	2014	Publication	Augmented Vision and Reality	Abbreviated Journal
	Volume	6	Issue		Pages	23-47
	Keywords
	Abstract	Moving cast shadows are a major concern in today’s performance from broad range of many vision-based surveillance applications because they highly difficult the object classification task. Several shadow detection methods have been reported in the literature during the last years. They are mainly divided into two domains. One usually works with static images, whereas the second one uses image sequences, namely video content. In spite of the fact that both cases can be analogously analyzed, there is a difference in the application field. The first case, shadow detection methods can be exploited in order to obtain additional geometric and semantic cues about shape and position of its casting object (‘shape from shadows’) as well as the localization of the light source. While in the second one, the main purpose is usually change detection, scene matching or surveillance (usually in a background subtraction context). Shadows can in fact modify in a negative way the shape and color of the target object and therefore affect the performance of scene analysis and interpretation in many applications. This chapter wills mainly reviews shadow detection methods as well as their taxonomies related with the second case, thus aiming at those shadows which are associated with moving objects (moving shadows).
	Address
	Corporate Author				Thesis
	Publisher	Springer Berlin Heidelberg	Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	2190-5916	ISBN	978-3-642-37840-9	Medium
	Area		Expedition		Conference
	Notes	ISE; 605.203; 600.049; 302.018; 302.012; 600.078			Approved	no
	Call Number	Admin @ si @ AHM2014			Serial	2223
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	Author	David Roche; Debora Gil; Jesus Giraldo
	Title	Mathematical modeling of G protein-coupled receptor function: What can we learn from empirical and mechanistic models?			Type	Book Chapter
	Year	2014	Publication	G Protein-Coupled Receptors – Modeling and Simulation Advances in Experimental Medicine and Biology	Abbreviated Journal
	Volume	796	Issue	3	Pages	159-181
	Keywords	β-arrestin; biased agonism; curve fitting; empirical modeling; evolutionary algorithm; functional selectivity; G protein; GPCR; Hill coefficient; intrinsic efficacy; inverse agonism; mathematical modeling; mechanistic modeling; operational model; parameter optimization; receptor dimer; receptor oligomerization; receptor constitutive activity; signal transduction; two-state model
	Abstract	Empirical and mechanistic models differ in their approaches to the analysis of pharmacological effect. Whereas the parameters of the former are not physical constants those of the latter embody the nature, often complex, of biology. Empirical models are exclusively used for curve fitting, merely to characterize the shape of the E/[A] curves. Mechanistic models, on the contrary, enable the examination of mechanistic hypotheses by parameter simulation. Regretfully, the many parameters that mechanistic models may include can represent a great difficulty for curve fitting, representing, thus, a challenge for computational method development. In the present study some empirical and mechanistic models are shown and the connections, which may appear in a number of cases between them, are analyzed from the curves they yield. It may be concluded that systematic and careful curve shape analysis can be extremely useful for the understanding of receptor function, ligand classification and drug discovery, thus providing a common language for the communication between pharmacologists and medicinal chemists.
	Address
	Corporate Author				Thesis
	Publisher	Springer Netherlands	Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0065-2598	ISBN	978-94-007-7422-3	Medium
	Area		Expedition		Conference
	Notes	IAM; 600.075			Approved	no
	Call Number	IAM @ iam @ RGG2014			Serial	2197
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