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Enric Marti, Jordi Regincos, Jaime Lopez-Krahe, & Juan J.Villanueva. (1993). Hand line drawing interpretation as three-dimensional objects. Signal Processing – Intelligent systems for signal and image understanding, 32(1-2), 91–110.
Abstract: In this paper we present a technique to interpret hand line drawings as objects in a three-dimensional space. The object domain considered is based on planar surfaces with straight edges, concretely, on ansextension of Origami world to hidden lines. The line drawing represents the object under orthographic projection and it is sensed using a scanner. Our method is structured in two modules: feature extraction and feature interpretation. In the first one, image processing techniques are applied under certain tolerance margins to detect lines and junctions on the hand line drawing. Feature interpretation module is founded on line labelling techniques using a labelled junction dictionary. A labelling algorithm is here proposed. It uses relaxation techniques to reduce the number of incompatible labels with the junction dictionary so that the convergence of solutions can be accelerated. We formulate some labelling hypotheses tending to eliminate elements in two sets of labelled interpretations. That is, those which are compatible with the dictionary but do not correspond to three-dimensional objects and those which represent objects not very probable to be specified by means of a line drawing. New entities arise on the line drawing as a result of the extension of Origami world. These are defined to enunciate the assumptions of our method as well as to clarify the algorithms proposed. This technique is framed in a project aimed to implement a system to create 3D objects to improve man-machine interaction in CAD systems.
Keywords: Line drawing interpretation; line labelling; scene analysis; man-machine interaction; CAD input; line extraction
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Mariano Vazquez, Ruth Aris, Guillaume Hozeaux, R.Aubry, P.Villar, Jaume Garcia, et al. (2011). A massively parallel computational electrophysiology model of the heart. IJNMBE - International Journal for Numerical Methods in Biomedical Engineering, 27, 1911–1929.
Abstract: This paper presents a patient-sensitive simulation strategy capable of using the most efficient way the high-performance computational resources. The proposed strategy directly involves three different players: Computational Mechanics Scientists (CMS), Image Processing Scientists and Cardiologists, each one mastering its own expertise area within the project. This paper describes the general integrative scheme but focusing on the CMS side presents a massively parallel implementation of computational electrophysiology applied to cardiac tissue simulation. The paper covers different angles of the computational problem: equations, numerical issues, the algorithm and parallel implementation. The proposed methodology is illustrated with numerical simulations testing all the different possibilities, ranging from small domains up to very large ones. A key issue is the almost ideal scalability not only for large and complex problems but also for medium-size meshes. The explicit formulation is particularly well suited for solving this highly transient problems, with very short time-scale.
Keywords: computational electrophysiology; parallelization; finite element methods
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Sergio Vera, Debora Gil, Antonio Lopez, & Miguel Angel Gonzalez Ballester. (2012). Multilocal Creaseness Measure. IJ - The Insight Journal.
Abstract: This document describes the implementation using the Insight Toolkit of an algorithm for detecting creases (ridges and valleys) in N-dimensional images, based on the Local Structure Tensor of the image. In addition to the filter used to calculate the creaseness image, a filter for the computation of the structure tensor is also included in this submission.
Keywords: Ridges, Valley, Creaseness, Structure Tensor, Skeleton,
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Josep Llados, Horst Bunke, & Enric Marti. (1997). Finding rotational symmetries by cyclic string matching. PRL - Pattern recognition letters, 18(14), 1435–1442.
Abstract: Symmetry is an important shape feature. In this paper, a simple and fast method to detect perfect and distorted rotational symmetries of 2D objects is described. The boundary of a shape is polygonally approximated and represented as a string. Rotational symmetries are found by cyclic string matching between two identical copies of the shape string. The set of minimum cost edit sequences that transform the shape string to a cyclically shifted version of itself define the rotational symmetry and its order. Finally, a modification of the algorithm is proposed to detect reflectional symmetries. Some experimental results are presented to show the reliability of the proposed algorithm
Keywords: Rotational symmetry; Reflectional symmetry; String matching
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David Roche, Debora Gil, & Jesus Giraldo. (2013). Multiple active receptor conformation, agonist efficacy and maximum effect of the system: the conformation-based operational model of agonism,. DDT - Drug Discovery Today, 18(7-8), 365–371.
Abstract: The operational model of agonism assumes that the maximum effect a particular receptor system can achieve (the Em parameter) is fixed. Em estimates are above but close to the asymptotic maximum effects of endogenous agonists. The concept of Em is contradicted by superagonists and those positive allosteric modulators that significantly increase the maximum effect of endogenous agonists. An extension of the operational model is proposed that assumes that the Em parameter does not necessarily have a single value for a receptor system but has multiple values associated to multiple active receptor conformations. The model provides a mechanistic link between active receptor conformation and agonist efficacy, which can be useful for the analysis of agonist response under different receptor scenarios.
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