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Rozenn Dhayot, Fernando Vilariño, & Gerard Lacey. (2008). Improving the Quality of Color Colonoscopy Videos. EURASIP JIVP - EURASIP Journal on Image and Video Processing, 139429(1), 1–9.
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Carolina Malagelada, Michal Drozdzal, Santiago Segui, Sara Mendez, Jordi Vitria, Petia Radeva, et al. (2015). Classification of functional bowel disorders by objective physiological criteria based on endoluminal image analysis. AJPGI - American Journal of Physiology-Gastrointestinal and Liver Physiology, 309(6), G413–G419.
Abstract: We have previously developed an original method to evaluate small bowel motor function based on computer vision analysis of endoluminal images obtained by capsule endoscopy. Our aim was to demonstrate intestinal motor abnormalities in patients with functional bowel disorders by endoluminal vision analysis. Patients with functional bowel disorders (n = 205) and healthy subjects (n = 136) ingested the endoscopic capsule (Pillcam-SB2, Given-Imaging) after overnight fast and 45 min after gastric exit of the capsule a liquid meal (300 ml, 1 kcal/ml) was administered. Endoluminal image analysis was performed by computer vision and machine learning techniques to define the normal range and to identify clusters of abnormal function. After training the algorithm, we used 196 patients and 48 healthy subjects, completely naive, as test set. In the test set, 51 patients (26%) were detected outside the normal range (P < 0.001 vs. 3 healthy subjects) and clustered into hypo- and hyperdynamic subgroups compared with healthy subjects. Patients with hypodynamic behavior (n = 38) exhibited less luminal closure sequences (41 ± 2% of the recording time vs. 61 ± 2%; P < 0.001) and more static sequences (38 ± 3 vs. 20 ± 2%; P < 0.001); in contrast, patients with hyperdynamic behavior (n = 13) had an increased proportion of luminal closure sequences (73 ± 4 vs. 61 ± 2%; P = 0.029) and more high-motion sequences (3 ± 1 vs. 0.5 ± 0.1%; P < 0.001). Applying an original methodology, we have developed a novel classification of functional gut disorders based on objective, physiological criteria of small bowel function.
Keywords: capsule endoscopy; computer vision analysis; functional bowel disorders; intestinal motility; machine learning
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Santiago Segui, Laura Igual, & Jordi Vitria. (2013). Bagged One Class Classifiers in the Presence of Outliers. IJPRAI - International Journal of Pattern Recognition and Artificial Intelligence, 27(5), 1350014–1350035.
Abstract: The problem of training classifiers only with target data arises in many applications where non-target data are too costly, difficult to obtain, or not available at all. Several one-class classification methods have been presented to solve this problem, but most of the methods are highly sensitive to the presence of outliers in the target class. Ensemble methods have therefore been proposed as a powerful way to improve the classification performance of binary/multi-class learning algorithms by introducing diversity into classifiers.
However, their application to one-class classification has been rather limited. In
this paper, we present a new ensemble method based on a non-parametric weighted bagging strategy for one-class classification, to improve accuracy in the presence of outliers. While the standard bagging strategy assumes a uniform data distribution, the method we propose here estimates a probability density based on a forest structure of the data. This assumption allows the estimation of data distribution from the computation of simple univariate and bivariate kernel densities. Experiments using original and noisy versions of 20 different datasets show that bagging ensemble methods applied to different one-class classifiers outperform base one-class classification methods. Moreover, we show that, in noisy versions of the datasets, the non-parametric weighted bagging strategy we propose outperforms the classical bagging strategy in a statistically significant way.
Keywords: One-class Classifier; Ensemble Methods; Bagging and Outliers
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Carolina Malagelada, F.De Lorio, Santiago Segui, S. Mendez, Michal Drozdzal, Jordi Vitria, et al. (2012). Functional gut disorders or disordered gut function? Small bowel dysmotility evidenced by an original technique. NEUMOT - Neurogastroenterology & Motility, 24(3), 223–230.
Abstract: JCR Impact Factor 2010: 3.349
Background This study aimed to determine the proportion of cases with abnormal intestinal motility among patients with functional bowel disorders. To this end, we applied an original method, previously developed in our laboratory, for analysis of endoluminal images obtained by capsule endoscopy. This novel technology is based on computer vision and machine learning techniques.
Methods The endoscopic capsule (Pillcam SB1; Given Imaging, Yokneam, Israel) was administered to 80 patients with functional bowel disorders and 70 healthy subjects. Endoluminal image analysis was performed with a computer vision program developed for the evaluation of contractile events (luminal occlusions and radial wrinkles), non-contractile patterns (open tunnel and smooth wall patterns), type of content (secretions, chyme) and motion of wall and contents. Normality range and discrimination of abnormal cases were established by a machine learning technique. Specifically, an iterative classifier (one-class support vector machine) was applied in a random population of 50 healthy subjects as a training set and the remaining subjects (20 healthy subjects and 80 patients) as a test set.
Key Results The classifier identified as abnormal 29% of patients with functional diseases of the bowel (23 of 80), and as normal 97% of healthy subjects (68 of 70) (P < 0.05 by chi-squared test). Patients identified as abnormal clustered in two groups, which exhibited either a hyper- or a hypodynamic motility pattern. The motor behavior was unrelated to clinical features.
Conclusions & Inferences With appropriate methodology, abnormal intestinal motility can be demonstrated in a significant proportion of patients with functional bowel disorders, implying a pathologic disturbance of gut physiology.
Keywords: capsule endoscopy;computer vision analysis;machine learning technique;small bowel motility
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Fosca De Iorio, C. Malagelada, Fernando Azpiroz, M. Maluenda, C. Violanti, Laura Igual, et al. (2009). Intestinal motor activity, endoluminal motion and transit. NEUMOT - Neurogastroenterology & Motility, 21(12), 1264–e119.
Abstract: A programme for evaluation of intestinal motility has been recently developed based on endoluminal image analysis using computer vision methodology and machine learning techniques. Our aim was to determine the effect of intestinal muscle inhibition on wall motion, dynamics of luminal content and transit in the small bowel. Fourteen healthy subjects ingested the endoscopic capsule (Pillcam, Given Imaging) in fasting conditions. Seven of them received glucagon (4.8 microg kg(-1) bolus followed by a 9.6 microg kg(-1) h(-1) infusion during 1 h) and in the other seven, fasting activity was recorded, as controls. This dose of glucagon has previously shown to inhibit both tonic and phasic intestinal motor activity. Endoluminal image and displacement was analyzed by means of a computer vision programme specifically developed for the evaluation of muscular activity (contractile and non-contractile patterns), intestinal contents, endoluminal motion and transit. Thirty-minute periods before, during and after glucagon infusion were analyzed and compared with equivalent periods in controls. No differences were found in the parameters measured during the baseline (pretest) periods when comparing glucagon and control experiments. During glucagon infusion, there was a significant reduction in contractile activity (0.2 +/- 0.1 vs 4.2 +/- 0.9 luminal closures per min, P < 0.05; 0.4 +/- 0.1 vs 3.4 +/- 1.2% of images with radial wrinkles, P < 0.05) and a significant reduction of endoluminal motion (82 +/- 9 vs 21 +/- 10% of static images, P < 0.05). Endoluminal image analysis, by means of computer vision and machine learning techniques, can reliably detect reduced intestinal muscle activity and motion.
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