Abstract: OBJECTIVES:
The aim of the study was to address the need for quantifying the global cancer time evolution magnitude from a pair of time-consecutive positron emission tomography-computed tomography (PET-CT) scans. In particular, we focus on the computation of indicators using image-processing techniques that seek to model non-Hodgkin's lymphoma (NHL) progression or response severity.
MATERIALS AND METHODS:
A total of 89 pairs of time-consecutive PET-CT scans from NHL patients were stored in a nuclear medicine station for subsequent analysis. These were classified by a consensus of nuclear medicine physicians into progressions, partial responses, mixed responses, complete responses, and relapses. The cases of each group were ordered by magnitude following visual analysis. Thereafter, a set of quantitative indicators designed to model the cancer evolution magnitude within each group were computed using semiautomatic and automatic image-processing techniques. Performance evaluation of the proposed indicators was measured by a correlation analysis with the expert-based visual analysis.
RESULTS:
The set of proposed indicators achieved Pearson's correlation results in each group with respect to the expert-based visual analysis: 80.2% in progressions, 77.1% in partial response, 68.3% in mixed response, 88.5% in complete response, and 100% in relapse. In the progression and mixed response groups, the proposed indicators outperformed the common indicators used in clinical practice [changes in metabolic tumor volume, mean, maximum, peak standardized uptake value (SUV mean, SUV max, SUV peak), and total lesion glycolysis] by more than 40%.
CONCLUSION:
Computing global indicators of NHL response using PET-CT imaging techniques offers a strong correlation with the associated expert-based visual analysis, motivating the future incorporation of such quantitative and highly observer-independent indicators in oncological decision making or treatment response evaluation scenarios.

Abstract: Pairwise classification is a well-known class binarization technique that converts a multiclass problem into a number of two-class problems, one problem for each pair of classes. However, in the pairwise technique, nuisance votes of many irrelevant classifiers may result in a wrong class prediction. To overcome this problem, a simple, but efficient method is proposed and evaluated in this paper. The proposed method is based on excluding some classes and focusing on the most probable classes in the neighborhood space, named Local Crossing Off (LCO). This procedure is performed by employing a modified version of standard K-nearest neighbor and large margin nearest neighbor algorithms. The LCO method takes advantage of nearest neighbor classification algorithm because of its local learning behavior as well as the global behavior of powerful binary classifiers to discriminate between two classes. Combining these two properties in the proposed LCO technique will avoid the weaknesses of each method and will increase the efficiency of the whole classification system. On several benchmark datasets of varying size and difficulty, we found that the LCO approach leads to significant improvements using different base learners. The experimental results show that the proposed technique not only achieves better classification accuracy in comparison to other standard approaches, but also is computationally more efficient for tackling classification problems which have a relatively large number of target classes.

Abstract: One of the most widely used assumptions in supervised learning is that data is independent and identically distributed. This assumption does not hold true in many real cases. Sequential learning is the discipline of machine learning that deals with dependent data such that neighboring examples exhibit some kind of relationship. In the literature, there are different approaches that try to capture and exploit this correlation, by means of different methodologies. In this paper we focus on meta-learning strategies and, in particular, the stacked sequential learning approach. The main contribution of this work is two-fold: first, we generalize the stacked sequential learning. This generalization reflects the key role of neighboring interactions modeling. Second, we propose an effective and efficient way of capturing and exploiting sequential correlations that takes into account long-range interactions by means of a multi-scale pyramidal decomposition of the predicted labels. Additionally, this new method subsumes the standard stacked sequential learning approach. We tested the proposed method on two different classification tasks: text lines classification in a FAQ data set and image classification. Results on these tasks clearly show that our approach outperforms the standard stacked sequential learning. Moreover, we show that the proposed method allows to control the trade-off between the detail and the desired range of the interactions.