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Frederic Sampedro, Sergio Escalera, & Anna Puig. (2014). Iterative Multiclass Multiscale Stacked Sequential Learning: definition and application to medical volume segmentation. PRL - Pattern Recognition Letters, 46, 1–10.
Abstract: In this work we present the iterative multi-class multi-scale stacked sequential learning framework (IMMSSL), a novel learning scheme that is particularly suited for medical volume segmentation applications. This model exploits the inherent voxel contextual information of the structures of interest in order to improve its segmentation performance results. Without any feature set or learning algorithm prior assumption, the proposed scheme directly seeks to learn the contextual properties of a region from the predicted classifications of previous classifiers within an iterative scheme. Performance results regarding segmentation accuracy in three two-class and multi-class medical volume datasets show a significant improvement with respect to state of the art alternatives. Due to its easiness of implementation and its independence of feature space and learning algorithm, the presented machine learning framework could be taken into consideration as a first choice in complex volume segmentation scenarios.
Keywords: Machine learning; Sequential learning; Multi-class problems; Contextual learning; Medical volume segmentation
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Frederic Sampedro, & Sergio Escalera. (2015). Spatial codification of label predictions in Multi-scale Stacked Sequential Learning: A case study on multi-class medical volume segmentation. IETCV - IET Computer Vision, 9(3), 439–446.
Abstract: In this study, the authors propose the spatial codification of label predictions within the multi-scale stacked sequential learning (MSSL) framework, a successful learning scheme to deal with non-independent identically distributed data entries. After providing a motivation for this objective, they describe its theoretical framework based on the introduction of the blurred shape model as a smart descriptor to codify the spatial distribution of the predicted labels and define the new extended feature set for the second stacked classifier. They then particularise this scheme to be applied in volume segmentation applications. Finally, they test the implementation of the proposed framework in two medical volume segmentation datasets, obtaining significant performance improvements (with a 95% of confidence) in comparison to standard Adaboost classifier and classical MSSL approaches.
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Daniel Sanchez, Miguel Angel Bautista, & Sergio Escalera. (2015). HuPBA 8k+: Dataset and ECOC-GraphCut based Segmentation of Human Limbs. NEUCOM - Neurocomputing, 150(A), 173–188.
Abstract: Human multi-limb segmentation in RGB images has attracted a lot of interest in the research community because of the huge amount of possible applications in fields like Human-Computer Interaction, Surveillance, eHealth, or Gaming. Nevertheless, human multi-limb segmentation is a very hard task because of the changes in appearance produced by different points of view, clothing, lighting conditions, occlusions, and number of articulations of the human body. Furthermore, this huge pose variability makes the availability of large annotated datasets difficult. In this paper, we introduce the HuPBA8k+ dataset. The dataset contains more than 8000 labeled frames at pixel precision, including more than 120000 manually labeled samples of 14 different limbs. For completeness, the dataset is also labeled at frame-level with action annotations drawn from an 11 action dictionary which includes both single person actions and person-person interactive actions. Furthermore, we also propose a two-stage approach for the segmentation of human limbs. In a first stage, human limbs are trained using cascades of classifiers to be split in a tree-structure way, which is included in an Error-Correcting Output Codes (ECOC) framework to define a body-like probability map. This map is used to obtain a binary mask of the subject by means of GMM color modelling and GraphCuts theory. In a second stage, we embed a similar tree-structure in an ECOC framework to build a more accurate set of limb-like probability maps within the segmented user mask, that are fed to a multi-label GraphCut procedure to obtain final multi-limb segmentation. The methodology is tested on the novel HuPBA8k+ dataset, showing performance improvements in comparison to state-of-the-art approaches. In addition, a baseline of standard action recognition methods for the 11 actions categories of the novel dataset is also provided.
Keywords: Human limb segmentation; ECOC; Graph-Cuts
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Frederic Sampedro, Anna Domenech, Sergio Escalera, & Ignasi Carrio. (2015). Deriving global quantitative tumor response parameters from 18F-FDG PET-CT scans in patients with non-Hodgkins lymphoma. NMC - Nuclear Medicine Communications, 36(4), 328–333.
Abstract: OBJECTIVES:
The aim of the study was to address the need for quantifying the global cancer time evolution magnitude from a pair of time-consecutive positron emission tomography-computed tomography (PET-CT) scans. In particular, we focus on the computation of indicators using image-processing techniques that seek to model non-Hodgkin's lymphoma (NHL) progression or response severity.
MATERIALS AND METHODS:
A total of 89 pairs of time-consecutive PET-CT scans from NHL patients were stored in a nuclear medicine station for subsequent analysis. These were classified by a consensus of nuclear medicine physicians into progressions, partial responses, mixed responses, complete responses, and relapses. The cases of each group were ordered by magnitude following visual analysis. Thereafter, a set of quantitative indicators designed to model the cancer evolution magnitude within each group were computed using semiautomatic and automatic image-processing techniques. Performance evaluation of the proposed indicators was measured by a correlation analysis with the expert-based visual analysis.
RESULTS:
The set of proposed indicators achieved Pearson's correlation results in each group with respect to the expert-based visual analysis: 80.2% in progressions, 77.1% in partial response, 68.3% in mixed response, 88.5% in complete response, and 100% in relapse. In the progression and mixed response groups, the proposed indicators outperformed the common indicators used in clinical practice [changes in metabolic tumor volume, mean, maximum, peak standardized uptake value (SUV mean, SUV max, SUV peak), and total lesion glycolysis] by more than 40%.
CONCLUSION:
Computing global indicators of NHL response using PET-CT imaging techniques offers a strong correlation with the associated expert-based visual analysis, motivating the future incorporation of such quantitative and highly observer-independent indicators in oncological decision making or treatment response evaluation scenarios.
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Frederic Sampedro, Sergio Escalera, Anna Domenech, & Ignasi Carrio. (2014). A computational framework for cancer response assessment based on oncological PET-CT scans. CBM - Computers in Biology and Medicine, 55, 92–99.
Abstract: In this work we present a comprehensive computational framework to help in the clinical assessment of cancer response from a pair of time consecutive oncological PET-CT scans. In this scenario, the design and implementation of a supervised machine learning system to predict and quantify cancer progression or response conditions by introducing a novel feature set that models the underlying clinical context is described. Performance results in 100 clinical cases (corresponding to 200 whole body PET-CT scans) in comparing expert-based visual analysis and classifier decision making show up to 70% accuracy within a completely automatic pipeline and 90% accuracy when providing the system with expert-guided PET tumor segmentation masks.
Keywords: Computer aided diagnosis; Nuclear medicine; Machine learning; Image processing; Quantitative analysis
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