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G. Zahnd, Simone Balocco, A. Serusclat, P. Moulin, M. Orkisz, & D. Vray. (2015). Progressive attenuation of the longitudinal kinetics in the common carotid artery: preliminary in vivo assessment Ultrasound in Medicine and Biology. UMB - Ultrasound in Medicine and Biology, 41(1), 339–345.
Abstract: Longitudinal kinetics (LOKI) of the arterial wall consists of the shearing motion of the intima-media complex over the adventitia layer in the direction parallel to the blood flow during the cardiac cycle. The aim of this study was to investigate the local variability of LOKI amplitude along the length of the vessel. By use of a previously validated motion-estimation framework, 35 in vivo longitudinal B-mode ultrasound cine loops of healthy common carotid arteries were analyzed. Results indicated that LOKI amplitude is progressively attenuated along the length of the artery, as it is larger in regions located on the proximal side of the image (i.e., toward the heart) and smaller in regions located on the distal side of the image (i.e., toward the head), with an average attenuation coefficient of -2.5 ± 2.0%/mm. Reported for the first time in this study, this phenomenon is likely to be of great importance in improving understanding of atherosclerosis mechanisms, and has the potential to be a novel index of arterial stiffness.
Keywords: Arterial stiffness; Atherosclerosis; Common carotid artery; Longitudinal kinetics; Motion tracking; Ultrasound imaging
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Tadashi Araki, Nobutaka Ikeda, Nilanjan Dey, Sayan Chakraborty, Luca Saba, Dinesh Kumar, et al. (2015). A comparative approach of four different image registration techniques for quantitative assessment of coronary artery calcium lesions using intravascular ultrasound. CMPB - Computer Methods and Programs in Biomedicine, 118(2), 158–172.
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R.A.Bendezu, E.Barba, E.Burri, D.Cisternas, Carolina Malagelada, Santiago Segui, et al. (2015). Intestinal gas content and distribution in health and in patients with functional gut symptoms. NEUMOT - Neurogastroenterology & Motility, 27(9), 1249–1257.
Abstract: BACKGROUND:
The precise relation of intestinal gas to symptoms, particularly abdominal bloating and distension remains incompletely elucidated. Our aim was to define the normal values of intestinal gas volume and distribution and to identify abnormalities in relation to functional-type symptoms.
METHODS:
Abdominal computed tomography scans were evaluated in healthy subjects (n = 37) and in patients in three conditions: basal (when they were feeling well; n = 88), during an episode of abdominal distension (n = 82) and after a challenge diet (n = 24). Intestinal gas content and distribution were measured by an original analysis program. Identification of patients outside the normal range was performed by machine learning techniques (one-class classifier). Results are expressed as median (IQR) or mean ± SE, as appropriate.
KEY RESULTS:
In healthy subjects the gut contained 95 (71, 141) mL gas distributed along the entire lumen. No differences were detected between patients studied under asymptomatic basal conditions and healthy subjects. However, either during a spontaneous bloating episode or once challenged with a flatulogenic diet, luminal gas was found to be increased and/or abnormally distributed in about one-fourth of the patients. These patients detected outside the normal range by the classifier exhibited a significantly greater number of abnormal features than those within the normal range (3.7 ± 0.4 vs 0.4 ± 0.1; p < 0.001).
CONCLUSIONS & INFERENCES:
The analysis of a large cohort of subjects using original techniques provides unique and heretofore unavailable information on the volume and distribution of intestinal gas in normal conditions and in relation to functional gastrointestinal symptoms.
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G.Blasco, Simone Balocco, J.Puig, J.Sanchez-Gonzalez, W.Ricart, J.Daunis-I-Estadella, et al. (2015). Carotid pulse wave velocity by magnetic resonance imaging is increased in middle-aged subjects with the metabolic syndrome. ICJI - International Journal of Cardiovascular Imaging, 31(3), 603–612.
Abstract: Arterial pulse wave velocity (PWV), an independent predictor of cardiovascular disease, physiologically increases with age; however, growing evidence suggests metabolic syndrome (MetS) accelerates this increase. Magnetic resonance imaging (MRI) enables reliable noninvasive assessment of arterial stiffness by measuring arterial PWV in specific vascular segments. We investigated the association between the presence of MetS and its components with carotid PWV (cPWV) in asymptomatic subjects without diabetes. We assessed cPWV by MRI in 61 individuals (mean age, 55.3 ± 14.1 years; median age, 55 years): 30 with MetS and 31 controls with similar age, sex, body mass index, and LDL-cholesterol levels. The study population was dichotomized by the median age. To remove the physiological association between PWV and age, unpaired t tests and multiple regression analyses were performed using the residuals of the regression between PWV and age. cPWV was higher in middle-aged subjects with MetS than in those without (p = 0.001), but no differences were found in elder subjects (p = 0.313). cPWV was associated with diastolic blood pressure (r = 0.276, p = 0.033) and waist circumference (r = 0.268, p = 0.038). The presence of MetS was associated with increased cPWV regardless of age, sex, blood pressure, and waist (p = 0.007). The MetS components contributing independently to an increased cPWV were hypertension (p = 0.018) and hypertriglyceridemia (p = 0.002). The presence of MetS is associated with an increased cPWV in middle-aged subjects. In particular, hypertension and hypertriglyceridemia may contribute to early progression of carotid stiffness.
Keywords: Metabolic syndrome; Arterial stiffness; Pulse wave velocity; Carotid artery; Magnetic resonance
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Lluis Garrido, M.Guerrieri, & Laura Igual. (2015). Image Segmentation with Cage Active Contours. TIP - IEEE Transactions on Image Processing, 24(12), 5557–5566.
Abstract: In this paper, we present a framework for image segmentation based on parametrized active contours. The evolving contour is parametrized according to a reduced set of control points that form a closed polygon and have a clear visual interpretation. The parametrization, called mean value coordinates, stems from the techniques used in computer graphics to animate virtual models. Our framework allows to easily formulate region-based energies to segment an image. In particular, we present three different local region-based energy terms: 1) the mean model; 2) the Gaussian model; 3) and the histogram model. We show the behavior of our method on synthetic and real images and compare the performance with state-of-the-art level set methods.
Keywords: Level sets; Mean value coordinates; Parametrized active contours; level sets; mean value coordinates
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