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Cristina Sanchez Montes, F. Javier Sanchez, Jorge Bernal, Henry Cordova, Maria Lopez Ceron, Miriam Cuatrecasas, et al. (2019). Computer-aided Prediction of Polyp Histology on White-Light Colonoscopy using Surface Pattern Analysis. END - Endoscopy, 51(3), 261–265.
Abstract: Background and study aims: To evaluate a new computational histology prediction system based on colorectal polyp textural surface patterns using high definition white light images.
Patients and methods: Textural elements (textons) were characterized according to their contrast with respect to the surface, shape and number of bifurcations, assuming that dysplastic polyps are associated with highly contrasted, large tubular patterns with some degree of bifurcation. Computer-aided diagnosis (CAD) was compared with pathological diagnosis and the diagnosis by the endoscopists using Kudo and NICE classification.
Results: Images of 225 polyps were evaluated (142 dysplastic and 83 non-dysplastic). CAD system correctly classified 205 (91.1%) polyps, 131/142 (92.3%) dysplastic and 74/83 (89.2%) non-dysplastic. For the subgroup of 100 diminutive (<5 mm) polyps, CAD correctly classified 87 (87%) polyps, 43/50 (86%) dysplastic and 44/50 (88%) non-dysplastic. There were not statistically significant differences in polyp histology prediction based on CAD system and on endoscopist assessment.
Conclusion: A computer vision system based on the characterization of the polyp surface in the white light accurately predicts colorectal polyp histology.
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Jorge Bernal, Aymeric Histace, Marc Masana, Quentin Angermann, Cristina Sanchez Montes, Cristina Rodriguez de Miguel, et al. (2019). GTCreator: a flexible annotation tool for image-based datasets. IJCAR - International Journal of Computer Assisted Radiology and Surgery, 14(2), 191–201.
Abstract: Abstract Purpose: Methodology evaluation for decision support systems for health is a time consuming-task. To assess performance of polyp detection
methods in colonoscopy videos, clinicians have to deal with the annotation
of thousands of images. Current existing tools could be improved in terms of
exibility and ease of use. Methods:We introduce GTCreator, a exible annotation tool for providing image and text annotations to image-based datasets.
It keeps the main basic functionalities of other similar tools while extending
other capabilities such as allowing multiple annotators to work simultaneously
on the same task or enhanced dataset browsing and easy annotation transfer aiming to speed up annotation processes in large datasets. Results: The
comparison with other similar tools shows that GTCreator allows to obtain
fast and precise annotation of image datasets, being the only one which offers
full annotation editing and browsing capabilites. Conclusions: Our proposed
annotation tool has been proven to be efficient for large image dataset annota-
tion, as well as showing potential of use in other stages of method evaluation
such as experimental setup or results analysis.
Keywords: Annotation tool; Validation Framework; Benchmark; Colonoscopy; Evaluation
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Jorge Bernal, Nima Tajkbaksh, F. Javier Sanchez, Bogdan J. Matuszewski, Hao Chen, Lequan Yu, et al. (2017). Comparative Validation of Polyp Detection Methods in Video Colonoscopy: Results from the MICCAI 2015 Endoscopic Vision Challenge. TMI - IEEE Transactions on Medical Imaging, 36(6), 1231–1249.
Abstract: Colonoscopy is the gold standard for colon cancer screening though still some polyps are missed, thus preventing early disease detection and treatment. Several computational systems have been proposed to assist polyp detection during colonoscopy but so far without consistent evaluation. The lack
of publicly available annotated databases has made it difficult to compare methods and to assess if they achieve performance levels acceptable for clinical use. The Automatic Polyp Detection subchallenge, conducted as part of the Endoscopic Vision Challenge (http://endovis.grand-challenge.org) at the international conference on Medical Image Computing and Computer Assisted
Intervention (MICCAI) in 2015, was an effort to address this need. In this paper, we report the results of this comparative evaluation of polyp detection methods, as well as describe additional experiments to further explore differences between methods. We define performance metrics and provide evaluation databases that allow comparison of multiple methodologies. Results show that convolutional neural networks (CNNs) are the state of the art. Nevertheless it is also demonstrated that combining different methodologies can lead to an improved overall performance.
Keywords: Endoscopic vision; Polyp Detection; Handcrafted features; Machine Learning; Validation Framework
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Gloria Fernandez Esparrach, Jorge Bernal, Maria Lopez Ceron, Henry Cordova, Cristina Sanchez Montes, Cristina Rodriguez de Miguel, et al. (2016). Exploring the clinical potential of an automatic colonic polyp detection method based on the creation of energy maps. END - Endoscopy, 48(9), 837–842.
Abstract: Background and aims: Polyp miss-rate is a drawback of colonoscopy that increases significantly in small polyps. We explored the efficacy of an automatic computer vision method for polyp detection.
Methods: Our method relies on a model that defines polyp boundaries as valleys of image intensity. Valley information is integrated into energy maps which represent the likelihood of polyp presence.
Results: In 24 videos containing polyps from routine colonoscopies, all polyps were detected in at least one frame. Mean values of the maximum of energy map were higher in frames with polyps than without (p<0.001). Performance improved in high quality frames (AUC= 0.79, 95%CI: 0.70-0.87 vs 0.75, 95%CI: 0.66-0.83). Using 3.75 as maximum threshold value, sensitivity and specificity for detection of polyps were 70.4% (95%CI: 60.3-80.8) and 72.4% (95%CI: 61.6-84.6), respectively.
Conclusion: Energy maps showed a good performance for colonic polyp detection. This indicates a potential applicability in clinical practice.
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Cristina Sanchez Montes, Jorge Bernal, Ana Garcia Rodriguez, Henry Cordova, & Gloria Fernandez Esparrach. (2020). Revisión de métodos computacionales de detección y clasificación de pólipos en imagen de colonoscopia. GH - Gastroenterología y Hepatología, 43(4), 222–232.
Abstract: Computer-aided diagnosis (CAD) is a tool with great potential to help endoscopists in the tasks of detecting and histologically classifying colorectal polyps. In recent years, different technologies have been described and their potential utility has been increasingly evidenced, which has generated great expectations among scientific societies. However, most of these works are retrospective and use images of different quality and characteristics which are analysed off line. This review aims to familiarise gastroenterologists with computational methods and the particularities of endoscopic imaging, which have an impact on image processing analysis. Finally, the publicly available image databases, needed to compare and confirm the results obtained with different methods, are presented.
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