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Frederic Sampedro; Anna Domenech; Sergio Escalera |
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Title |
Static and dynamic computational cancer spread quantification in whole body FDG-PET/CT scans |
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2014 |
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Journal of Medical Imaging and Health Informatics |
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JMIHI |
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4 |
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6 |
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825-831 |
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CANCER SPREAD; COMPUTER AIDED DIAGNOSIS; MEDICAL IMAGING; TUMOR QUANTIFICATION |
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In this work we address the computational cancer spread quantification scenario in whole body FDG-PET/CT scans. At the static level, this setting can be modeled as a clustering problem on the set of 3D connected components of the whole body PET tumoral segmentation mask carried out by nuclear medicine physicians. At the dynamic level, and ad-hoc algorithm is proposed in order to quantify the cancer spread time evolution which, when combined with other existing indicators, gives rise to the metabolic tumor volume-aggressiveness-spread time evolution chart, a novel tool that we claim that would prove useful in nuclear medicine and oncological clinical or research scenarios. Good performance results of the proposed methodologies both at the clinical and technological level are shown using a dataset of 48 segmented whole body FDG-PET/CT scans. |
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HuPBA;MILAB |
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Admin @ si @ SDE2014b |
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2548 |
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Carolina Malagelada; Michal Drozdzal; Santiago Segui; Sara Mendez; Jordi Vitria; Petia Radeva; Javier Santos; Anna Accarino; Juan R. Malagelada; Fernando Azpiroz |
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Classification of functional bowel disorders by objective physiological criteria based on endoluminal image analysis |
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2015 |
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American Journal of Physiology-Gastrointestinal and Liver Physiology |
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AJPGI |
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309 |
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6 |
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G413--G419 |
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Keywords |
capsule endoscopy; computer vision analysis; functional bowel disorders; intestinal motility; machine learning |
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We have previously developed an original method to evaluate small bowel motor function based on computer vision analysis of endoluminal images obtained by capsule endoscopy. Our aim was to demonstrate intestinal motor abnormalities in patients with functional bowel disorders by endoluminal vision analysis. Patients with functional bowel disorders (n = 205) and healthy subjects (n = 136) ingested the endoscopic capsule (Pillcam-SB2, Given-Imaging) after overnight fast and 45 min after gastric exit of the capsule a liquid meal (300 ml, 1 kcal/ml) was administered. Endoluminal image analysis was performed by computer vision and machine learning techniques to define the normal range and to identify clusters of abnormal function. After training the algorithm, we used 196 patients and 48 healthy subjects, completely naive, as test set. In the test set, 51 patients (26%) were detected outside the normal range (P < 0.001 vs. 3 healthy subjects) and clustered into hypo- and hyperdynamic subgroups compared with healthy subjects. Patients with hypodynamic behavior (n = 38) exhibited less luminal closure sequences (41 ± 2% of the recording time vs. 61 ± 2%; P < 0.001) and more static sequences (38 ± 3 vs. 20 ± 2%; P < 0.001); in contrast, patients with hyperdynamic behavior (n = 13) had an increased proportion of luminal closure sequences (73 ± 4 vs. 61 ± 2%; P = 0.029) and more high-motion sequences (3 ± 1 vs. 0.5 ± 0.1%; P < 0.001). Applying an original methodology, we have developed a novel classification of functional gut disorders based on objective, physiological criteria of small bowel function. |
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American Physiological Society |
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MILAB; OR;MV |
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Admin @ si @ MDS2015 |
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2666 |
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Carolina Malagelada; F.De Lorio; Santiago Segui; S. Mendez; Michal Drozdzal; Jordi Vitria; Petia Radeva; J.Santos; Anna Accarino; Juan R. Malagelada; Fernando Azpiroz |
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Functional gut disorders or disordered gut function? Small bowel dysmotility evidenced by an original technique |
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2012 |
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Neurogastroenterology & Motility |
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NEUMOT |
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24 |
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3 |
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223-230 |
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capsule endoscopy;computer vision analysis;machine learning technique;small bowel motility |
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JCR Impact Factor 2010: 3.349
Background This study aimed to determine the proportion of cases with abnormal intestinal motility among patients with functional bowel disorders. To this end, we applied an original method, previously developed in our laboratory, for analysis of endoluminal images obtained by capsule endoscopy. This novel technology is based on computer vision and machine learning techniques.
Methods The endoscopic capsule (Pillcam SB1; Given Imaging, Yokneam, Israel) was administered to 80 patients with functional bowel disorders and 70 healthy subjects. Endoluminal image analysis was performed with a computer vision program developed for the evaluation of contractile events (luminal occlusions and radial wrinkles), non-contractile patterns (open tunnel and smooth wall patterns), type of content (secretions, chyme) and motion of wall and contents. Normality range and discrimination of abnormal cases were established by a machine learning technique. Specifically, an iterative classifier (one-class support vector machine) was applied in a random population of 50 healthy subjects as a training set and the remaining subjects (20 healthy subjects and 80 patients) as a test set.
Key Results The classifier identified as abnormal 29% of patients with functional diseases of the bowel (23 of 80), and as normal 97% of healthy subjects (68 of 70) (P < 0.05 by chi-squared test). Patients identified as abnormal clustered in two groups, which exhibited either a hyper- or a hypodynamic motility pattern. The motor behavior was unrelated to clinical features.
Conclusions & Inferences With appropriate methodology, abnormal intestinal motility can be demonstrated in a significant proportion of patients with functional bowel disorders, implying a pathologic disturbance of gut physiology. |
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Wiley Online Library |
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MILAB; OR; MV |
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Admin @ si @ MLS2012 |
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1830 |
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Frederic Sampedro; Sergio Escalera; Anna Domenech; Ignasi Carrio |
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A computational framework for cancer response assessment based on oncological PET-CT scans |
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2014 |
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Computers in Biology and Medicine |
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CBM |
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55 |
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92–99 |
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Computer aided diagnosis; Nuclear medicine; Machine learning; Image processing; Quantitative analysis |
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In this work we present a comprehensive computational framework to help in the clinical assessment of cancer response from a pair of time consecutive oncological PET-CT scans. In this scenario, the design and implementation of a supervised machine learning system to predict and quantify cancer progression or response conditions by introducing a novel feature set that models the underlying clinical context is described. Performance results in 100 clinical cases (corresponding to 200 whole body PET-CT scans) in comparing expert-based visual analysis and classifier decision making show up to 70% accuracy within a completely automatic pipeline and 90% accuracy when providing the system with expert-guided PET tumor segmentation masks. |
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HuPBA;MILAB |
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Admin @ si @ SED2014 |
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2606 |
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Author |
Mariella Dimiccoli |
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Title |
Fundamentals of cone regression |
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2016 |
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Journal of Statistics Surveys |
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10 |
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53-99 |
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cone regression; linear complementarity problems; proximal operators. |
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Cone regression is a particular case of quadratic programming that minimizes a weighted sum of squared residuals under a set of linear inequality constraints. Several important statistical problems such as isotonic, concave regression or ANOVA under partial orderings, just to name a few, can be considered as particular instances of the cone regression problem. Given its relevance in Statistics, this paper aims to address the fundamentals of cone regression from a theoretical and practical point of view. Several formulations of the cone regression problem are considered and, focusing on the particular case of concave regression as an example, several algorithms are analyzed and compared both qualitatively and quantitatively through numerical simulations. Several improvements to enhance numerical stability and bound the computational cost are proposed. For each analyzed algorithm, the pseudo-code and its corresponding code in Matlab are provided. The results from this study demonstrate that the choice of the optimization approach strongly impacts the numerical performances. It is also shown that methods are not currently available to solve efficiently cone regression problems with large dimension (more than many thousands of points). We suggest further research to fill this gap by exploiting and adapting classical multi-scale strategy to compute an approximate solution. |
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1935-7516 |
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MILAB; |
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Admin @ si @Dim2016a |
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2783 |
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