Abstract: OBJECTIVES:
The proposal and implementation of a computational framework for the quantification of structural renal damage from 99mTc-dimercaptosuccinic acid (DMSA) scans. The aim of this work is to propose, implement, and validate a computational framework for the quantification of structural renal damage from DMSA scans and in an observer-independent manner.
MATERIALS AND METHODS:
From a set of 16 pediatric DMSA-positive scans and 16 matched controls and using both expert-guided and automatic approaches, a set of image-derived quantitative indicators was computed based on the relative size, intensity and histogram distribution of the lesion. A correlation analysis was conducted in order to investigate the association of these indicators with other clinical data of interest in this scenario, including C-reactive protein (CRP), white cell count, vesicoureteral reflux, fever, relative perfusion, and the presence of renal sequelae in a 6-month follow-up DMSA scan.
RESULTS:
A fully automatic lesion detection and segmentation system was able to successfully classify DMSA-positive from negative scans (AUC=0.92, sensitivity=81% and specificity=94%). The image-computed relative size of the lesion correlated with the presence of fever and CRP levels (p<0.05), and a measurement derived from the distribution histogram of the lesion obtained significant performance results in the detection of permanent renal damage (AUC=0.86, sensitivity=100% and specificity=75%).
CONCLUSIONS:
The proposal and implementation of a computational framework for the quantification of structural renal damage from DMSA scans showed a promising potential to complement visual diagnosis and non-imaging indicators.

Abstract: Whole-body 3D PET/CT tumoral volume segmentation provides relevant diagnostic and prognostic information in clinical oncology and nuclear medicine. Carrying out this procedure manually by a medical expert is time consuming and suffers from inter- and intra-observer variabilities. In this paper, a completely automatic approach to this task is presented. First, the problem is stated and described both in clinical and technological terms. Then, a novel supervised learning segmentation framework is introduced. The segmentation by learning approach is defined within a Cascade of Adaboost classifiers and a 3D contextual proposal of Multiscale Stacked Sequential Learning. Segmentation accuracy results on 200 Breast Cancer whole body PET/CT volumes show mean 49% sensitivity, 99.993% specificity and 39% Jaccard overlap Index, which represent good performance results both at the clinical and technological level.

Abstract: Convolutional Neural Networks are the de facto models for image recognition. However 3D CNNs, the straight forward extension of 2D CNNs for video recognition, have not achieved the same success on standard action recognition benchmarks. One of the main reasons for this reduced performance of 3D CNNs is the increased computational complexity requiring large scale annotated datasets to train them in scale. 3D kernel factorization approaches have been proposed to reduce the complexity of 3D CNNs. Existing kernel factorization approaches follow hand-designed and hard-wired techniques. In this paper we propose Gate-Shift-Fuse (GSF), a novel spatio-temporal feature extraction module which controls interactions in spatio-temporal decomposition and learns to adaptively route features through time and combine them in a data dependent manner. GSF leverages grouped spatial gating to decompose input tensor and channel weighting to fuse the decomposed tensors. GSF can be inserted into existing 2D CNNs to convert them into an efficient and high performing spatio-temporal feature extractor, with negligible parameter and compute overhead. We perform an extensive analysis of GSF using two popular 2D CNN families and achieve state-of-the-art or competitive performance on five standard action recognition benchmarks.