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H. Martin Kjer, Jens Fagertun, Sergio Vera, Debora Gil, Miguel Angel Gonzalez Ballester, & Rasmus R. Paulsena. (2016). Free-form image registration of human cochlear uCT data using skeleton similarity as anatomical prior. PRL - Patter Recognition Letters, 76(1), 76–82.
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Guillermo Torres, Sonia Baeza, Carles Sanchez, Ignasi Guasch, Antoni Rosell, & Debora Gil. (2022). An Intelligent Radiomic Approach for Lung Cancer Screening. APPLSCI - Applied Sciences, 12(3), 1568.
Abstract: The efficiency of lung cancer screening for reducing mortality is hindered by the high rate of false positives. Artificial intelligence applied to radiomics could help to early discard benign cases from the analysis of CT scans. The available amount of data and the fact that benign cases are a minority, constitutes a main challenge for the successful use of state of the art methods (like deep learning), which can be biased, over-fitted and lack of clinical reproducibility. We present an hybrid approach combining the potential of radiomic features to characterize nodules in CT scans and the generalization of the feed forward networks. In order to obtain maximal reproducibility with minimal training data, we propose an embedding of nodules based on the statistical significance of radiomic features for malignancy detection. This representation space of lesions is the input to a feed
forward network, which architecture and hyperparameters are optimized using own-defined metrics of the diagnostic power of the whole system. Results of the best model on an independent set of patients achieve 100% of sensitivity and 83% of specificity (AUC = 0.94) for malignancy detection.
Keywords: Lung cancer; Early diagnosis; Screening; Neural networks; Image embedding; Architecture optimization
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Guillermo Torres, Debora Gil, Antoni Rosell, S. Mena, & Carles Sanchez. (2023). Virtual Radiomics Biopsy for the Histological Diagnosis of Pulmonary Nodules – Intermediate Results of the RadioLung Project. IJCARS - International Journal of Computer Assisted Radiology and Surgery, .
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Guillermo Torres, & Debora Gil. (2020). A multi-shape loss function with adaptive class balancing for the segmentation of lung structures. IJCAR - International Journal of Computer Assisted Radiology and Surgery, 15(1), S154–55.
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Francesc Carreras, Jaume Garcia, Debora Gil, Sandra Pujadas, Chi ho Lion, R.Suarez-Arias, et al. (2012). Left ventricular torsion and longitudinal shortening: two fundamental components of myocardial mechanics assessed by tagged cine-MRI in normal subjects. IJCI - International Journal of Cardiovascular Imaging, 28(2), 273–284.
Abstract: Cardiac magnetic resonance imaging (Cardiac MRI) has become a gold standard diagnostic technique for the assessment of cardiac mechanics, allowing the non-invasive calculation of left ventric- ular long axis longitudinal shortening (LVLS) and absolute myocardial torsion (AMT) between basal and apical left ventricular slices, a movement directly related to the helicoidal anatomic disposition of the myocardial fibers. The aim of this study is to determine AMT and LVLS behaviour and normal values from a group of healthy subjects. A group of 21 healthy volunteers (15 males) (age: 23–55 y.o., mean:30.7 ± 7.5) were prospectively included in an obser- vational study by Cardiac MRI. Left ventricular rotation (degrees) was calculated by custom-made software (Harmonic Phase Flow) in consecutive LV short axis planes tagged cine-MRI sequences. AMT was determined from the difference between basal and apical planes LV rotations. LVLS (%) was determined from the LV longitudinal and horizontal axis cine-MRI images. All the 21 cases studied were interpretable, although in three cases the value of the LV apical rotation could not be determined. The mean rotation of the basal and apical planes at end-systole were -3.71° ± 0.84° and 6.73° ± 1.69° (n:18) respectively, resulting in a LV mean AMT of 10.48° ± 1.63° (n:18). End-systolic mean LVLS was 19.07 ± 2.71%. Cardiac MRI allows for the calculation of AMT and LVLS, fundamental functional components of the ventricular twist mechanics conditioned, in turn, by the anatomical helical layout of the myocardial fibers. These values provide complementary information about systolic ventricular function in relation to the traditional parameters used in daily practice.
Keywords: Magnetic resonance imaging (MRI); Tagging MRI; Cardiac mechanics; Ventricular torsion
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