Abstract: Quantification of tumor heterogeneity is essential to better understand cancer progression and to adapt therapeutic treatments to patient specificities. Bioinformatic tools to assess the different cell populations from single-omic datasets as bulk transcriptome or methylome samples have been recently developed, including reference-based and reference-free methods. Improved methods using multi-omic datasets are yet to be developed in the future and the community would need systematic tools to perform a comparative evaluation of these algorithms on controlled data.

Abstract: One of the challenges in computer vision models, especially sign language, is real-time recognition. In this work, we present a simple yet low-complex and efficient model, comprising single shot detector, 2D convolutional neural network, singular value decomposition (SVD), and long short term memory, to real-time isolated hand sign language recognition (IHSLR) from RGB video. We employ the SVD method as an efficient, compact, and discriminative feature extractor from the estimated 3D hand keypoints coordinators. Despite the previous works that employ the estimated 3D hand keypoints coordinates as raw features, we propose a novel and revolutionary way to apply the SVD to the estimated 3D hand keypoints coordinates to get more discriminative features. SVD method is also applied to the geometric relations between the consecutive segments of each finger in each hand and also the angles between these sections. We perform a detailed analysis of recognition time and accuracy. One of our contributions is that this is the first time that the SVD method is applied to the hand pose parameters. Results on four datasets, RKS-PERSIANSIGN (99.5±0.04), First-Person (91±0.06), ASVID (93±0.05), and isoGD (86.1±0.04), confirm the efficiency of our method in both accuracy (mean+std) and time recognition. Furthermore, our model outperforms or gets competitive results with the state-of-the-art alternatives in IHSLR and hand action recognition.