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Author Frederic Sampedro; Anna Domenech; Sergio Escalera edit  url
doi  openurl
  Title Static and dynamic computational cancer spread quantification in whole body FDG-PET/CT scans Type Journal Article
  Year (down) 2014 Publication Journal of Medical Imaging and Health Informatics Abbreviated Journal JMIHI  
  Volume 4 Issue 6 Pages 825-831  
  Keywords CANCER SPREAD; COMPUTER AIDED DIAGNOSIS; MEDICAL IMAGING; TUMOR QUANTIFICATION  
  Abstract In this work we address the computational cancer spread quantification scenario in whole body FDG-PET/CT scans. At the static level, this setting can be modeled as a clustering problem on the set of 3D connected components of the whole body PET tumoral segmentation mask carried out by nuclear medicine physicians. At the dynamic level, and ad-hoc algorithm is proposed in order to quantify the cancer spread time evolution which, when combined with other existing indicators, gives rise to the metabolic tumor volume-aggressiveness-spread time evolution chart, a novel tool that we claim that would prove useful in nuclear medicine and oncological clinical or research scenarios. Good performance results of the proposed methodologies both at the clinical and technological level are shown using a dataset of 48 segmented whole body FDG-PET/CT scans.  
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  Notes HuPBA;MILAB Approved no  
  Call Number Admin @ si @ SDE2014b Serial 2548  
Permanent link to this record
 

 
Author Frederic Sampedro; Sergio Escalera; Anna Domenech; Ignasi Carrio edit  doi
openurl 
  Title A computational framework for cancer response assessment based on oncological PET-CT scans Type Journal Article
  Year (down) 2014 Publication Computers in Biology and Medicine Abbreviated Journal CBM  
  Volume 55 Issue Pages 92–99  
  Keywords Computer aided diagnosis; Nuclear medicine; Machine learning; Image processing; Quantitative analysis  
  Abstract In this work we present a comprehensive computational framework to help in the clinical assessment of cancer response from a pair of time consecutive oncological PET-CT scans. In this scenario, the design and implementation of a supervised machine learning system to predict and quantify cancer progression or response conditions by introducing a novel feature set that models the underlying clinical context is described. Performance results in 100 clinical cases (corresponding to 200 whole body PET-CT scans) in comparing expert-based visual analysis and classifier decision making show up to 70% accuracy within a completely automatic pipeline and 90% accuracy when providing the system with expert-guided PET tumor segmentation masks.  
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  Notes HuPBA;MILAB Approved no  
  Call Number Admin @ si @ SED2014 Serial 2606  
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Author Frederic Sampedro; Sergio Escalera; Anna Puig edit  doi
openurl 
  Title Iterative Multiclass Multiscale Stacked Sequential Learning: definition and application to medical volume segmentation Type Journal Article
  Year (down) 2014 Publication Pattern Recognition Letters Abbreviated Journal PRL  
  Volume 46 Issue Pages 1-10  
  Keywords Machine learning; Sequential learning; Multi-class problems; Contextual learning; Medical volume segmentation  
  Abstract In this work we present the iterative multi-class multi-scale stacked sequential learning framework (IMMSSL), a novel learning scheme that is particularly suited for medical volume segmentation applications. This model exploits the inherent voxel contextual information of the structures of interest in order to improve its segmentation performance results. Without any feature set or learning algorithm prior assumption, the proposed scheme directly seeks to learn the contextual properties of a region from the predicted classifications of previous classifiers within an iterative scheme. Performance results regarding segmentation accuracy in three two-class and multi-class medical volume datasets show a significant improvement with respect to state of the art alternatives. Due to its easiness of implementation and its independence of feature space and learning algorithm, the presented machine learning framework could be taken into consideration as a first choice in complex volume segmentation scenarios.  
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  Area Expedition Conference  
  Notes HuPBA;MILAB Approved no  
  Call Number Admin @ si @ SEP2014 Serial 2550  
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Author Laura Igual; Xavier Perez Sala; Sergio Escalera; Cecilio Angulo; Fernando De la Torre edit   pdf
url  doi
openurl 
  Title Continuous Generalized Procrustes Analysis Type Journal Article
  Year (down) 2014 Publication Pattern Recognition Abbreviated Journal PR  
  Volume 47 Issue 2 Pages 659–671  
  Keywords Procrustes analysis; 2D shape model; Continuous approach  
  Abstract PR4883, PII: S0031-3203(13)00327-0
Two-dimensional shape models have been successfully applied to solve many problems in computer vision, such as object tracking, recognition, and segmentation. Typically, 2D shape models are learned from a discrete set of image landmarks (corresponding to projection of 3D points of an object), after applying Generalized Procustes Analysis (GPA) to remove 2D rigid transformations. However, the
standard GPA process suffers from three main limitations. Firstly, the 2D training samples do not necessarily cover a uniform sampling of all the 3D transformations of an object. This can bias the estimate of the shape model. Secondly, it can be computationally expensive to learn the shape model by sampling 3D transformations. Thirdly, standard GPA methods use only one reference shape, which can might be insufficient to capture large structural variability of some objects.
To address these drawbacks, this paper proposes continuous generalized Procrustes analysis (CGPA).
CGPA uses a continuous formulation that avoids the need to generate 2D projections from all the rigid 3D transformations. It builds an efficient (in space and time) non-biased 2D shape model from a set of 3D model of objects. A major challenge in CGPA is the need to integrate over the space of 3D rotations, especially when the rotations are parameterized with Euler angles. To address this problem, we introduce the use of the Haar measure. Finally, we extended CGPA to incorporate several reference shapes. Experimental results on synthetic and real experiments show the benefits of CGPA over GPA.
 
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  Notes OR; HuPBA; 605.203; 600.046;MILAB Approved no  
  Call Number Admin @ si @ IPE2014 Serial 2352  
Permanent link to this record
 

 
Author Miguel Angel Bautista; Sergio Escalera; Oriol Pujol edit   pdf
doi  openurl
  Title On the Design of an ECOC-Compliant Genetic Algorithm Type Journal Article
  Year (down) 2014 Publication Pattern Recognition Abbreviated Journal PR  
  Volume 47 Issue 2 Pages 865-884  
  Keywords  
  Abstract Genetic Algorithms (GA) have been previously applied to Error-Correcting Output Codes (ECOC) in state-of-the-art works in order to find a suitable coding matrix. Nevertheless, none of the presented techniques directly take into account the properties of the ECOC matrix. As a result the considered search space is unnecessarily large. In this paper, a novel Genetic strategy to optimize the ECOC coding step is presented. This novel strategy redefines the usual crossover and mutation operators in order to take into account the theoretical properties of the ECOC framework. Thus, it reduces the search space and lets the algorithm to converge faster. In addition, a novel operator that is able to enlarge the code in a smart way is introduced. The novel methodology is tested on several UCI datasets and four challenging computer vision problems. Furthermore, the analysis of the results done in terms of performance, code length and number of Support Vectors shows that the optimization process is able to find very efficient codes, in terms of the trade-off between classification performance and the number of classifiers. Finally, classification performance per dichotomizer results shows that the novel proposal is able to obtain similar or even better results while defining a more compact number of dichotomies and SVs compared to state-of-the-art approaches.  
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  Area Expedition Conference  
  Notes HuPBA;MILAB Approved no  
  Call Number Admin @ si @ BEP2013 Serial 2254  
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