PT Journal
AU Mireia Forns-Nadal
   Federico Sem
   Anna Mane
   Laura Igual
   Dani Guinart
   Oscar Vilarroya
TI Increased Nucleus Accumbens Volume in First-Episode Psychosis
SO Psychiatry Research-Neuroimaging
JI PRN
PY 2017
BP 57
EP 60
VL 263
DI 10.1016/j.pscychresns.2017.03.007
AB Nucleus accumbens has been reported as a key structure in the neurobiology of schizophrenia. Studies analyzing structural abnormalities have shown conflicting results, possibly related to confounding factors. We investigated the nucleus accumbens volume using manual delimitation in first-episode psychosis (FEP) controlling for age, cannabis use and medication. Thirty-one FEP subjects who were naive or minimally exposed to antipsychotics and a control group were MRI scanned and clinically assessed from baseline to 6 months of follow-up. FEP showed increased relative and total accumbens volumes. Clinical correlations with negative symptoms, duration of untreated psychosis and cannabis use were not significant.
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