TY  - JOUR
AU  - Frederic Sampedro
AU  - Anna Domenech
AU  - Sergio Escalera
PY  - 2014//
TI  - Obtaining quantitative global tumoral state indicators based on whole-body PET/CT scans: A breast cancer case study
T2  - NMC
JO  - Nuclear Medicine Communications
SP  - 362
EP  - 371
VL  - 35
IS  - 4
N2  - Objectives: In this work we address the need for the computation of quantitative global tumoral state indicators from oncological whole-body PET/computed tomography scans. The combination of such indicators with other oncological information such as tumor markers or biopsy results would prove useful in oncological decision-making scenarios.Materials and methods: From an ordering of 100 breast cancer patients on the basis of oncological state through visual analysis by a consensus of nuclear medicine specialists, a set of numerical indicators computed from image analysis of the PET/computed tomography scan is presented, which attempts to summarize a patient’s oncological state in a quantitative manner taking into consideration the total tumor volume, aggressiveness, and spread.Results: Results obtained by comparative analysis of the proposed indicators with respect to the experts’ evaluation show up to 87% Pearson’s correlation coefficient when providing expert-guided PET metabolic tumor volume segmentation and 64% correlation when using completely automatic image analysis techniques.Conclusion: Global quantitative tumor information obtained by whole-body PET/CT image analysis can prove useful in clinical nuclear medicine settings and oncological decision-making scenarios. The completely automatic computation of such indicators would improve its impact as time efficiency and specialist independence would be achieved.
UR  - http://www.ncbi.nlm.nih.gov/pubmed/24374574
N1  - HuPBA;MILAB
ID  - Frederic Sampedro2014
ER  -