TY  - JOUR
AU  - Xavier Carrillo
AU  - E Fernandez-Nofrerias
AU  - Francesco Ciompi
AU  - O. Rodriguez-Leor
AU  - Petia Radeva
AU  - Neus Salvatella
AU  - Oriol Pujol
AU  - J. Mauri
AU  - A. Bayes
PY  - 2011//
TI  - Changes in Radial Artery Volume Assessed Using Intravascular Ultrasound: A Comparison of Two Vasodilator Regimens in Transradial Coronary Intervention
T2  - JOIC
JO  - Journal of Invasive Cardiology
SP  - 401
EP  - 404
VL  - 23
IS  - 10
KW  - radial
KW  - vasodilator treatment
KW  - percutaneous coronary intervention
KW  - IVUS
KW  - volumetric IVUS analysis
N2  - OBJECTIVES:This study used intravascular ultrasound (IVUS) to evaluate radial artery volume changes after intraarterial administration of nitroglycerin and/or verapamil.BACKGROUND:Radial artery spasm, which is associated with radial artery size, is the main limitation of the transradial approach in percutaneous coronary interventions (PCI).METHODS:This prospective, randomized study compared the effect of two intra-arterial vasodilator regimens on radial artery volume: 0.2 mg of nitroglycerin plus 2.5 mg of verapamil (Group 1; n = 15) versus 2.5 mg of verapamil alone (Group 2; n = 15). Radial artery lumen volume was assessed using IVUS at two time points: at baseline (5 minutes after sheath insertion) and post-vasodilator (1 minute after drug administration). The luminal volume of the radial artery was computed using ECOC Random Fields (ECOC-RF), a technique used for automatic segmentation of luminal borders in longitudinal cut images from IVUS sequences.RESULTS:There was a significant increase in arterial lumen volume in both groups, with an increase from 451 ± 177 mm³ to 508 ± 192 mm³ (p = 0.001) in Group 1 and from 456 ± 188 mm³ to 509 ± 170 mm³ (p = 0.001) in Group 2. There were no significant differences between the groups in terms of absolute volume increase (58 mm³ versus 53 mm³, respectively; p = 0.65) or in relative volume increase (14% versus 20%, respectively; p = 0.69).CONCLUSIONS:Administration of nitroglycerin plus verapamil or verapamil alone to the radial artery resulted in similar increases in arterial lumen volume according to ECOC-RF IVUS measurements.
N1  - MILAB;HuPBA
ID  - Xavier Carrillo2011
ER  -