%0 Journal Article %T Changes in Radial Artery Volume Assessed Using Intravascular Ultrasound: A Comparison of Two Vasodilator Regimens in Transradial Coronary Intervention %A Xavier Carrillo %A E Fernandez-Nofrerias %A Francesco Ciompi %A O. Rodriguez-Leor %A Petia Radeva %A Neus Salvatella %A Oriol Pujol %A J. Mauri %A A. Bayes %J Journal of Invasive Cardiology %D 2011 %V 23 %N 10 %F Xavier Carrillo2011 %O MILAB;HuPBA %O exported from refbase (http://refbase.cvc.uab.es/show.php?record=1797), last updated on Fri, 07 Mar 2014 17:11:20 +0100 %X OBJECTIVES:This study used intravascular ultrasound (IVUS) to evaluate radial artery volume changes after intraarterial administration of nitroglycerin and/or verapamil.BACKGROUND:Radial artery spasm, which is associated with radial artery size, is the main limitation of the transradial approach in percutaneous coronary interventions (PCI).METHODS:This prospective, randomized study compared the effect of two intra-arterial vasodilator regimens on radial artery volume: 0.2 mg of nitroglycerin plus 2.5 mg of verapamil (Group 1; n = 15) versus 2.5 mg of verapamil alone (Group 2; n = 15). Radial artery lumen volume was assessed using IVUS at two time points: at baseline (5 minutes after sheath insertion) and post-vasodilator (1 minute after drug administration). The luminal volume of the radial artery was computed using ECOC Random Fields (ECOC-RF), a technique used for automatic segmentation of luminal borders in longitudinal cut images from IVUS sequences.RESULTS:There was a significant increase in arterial lumen volume in both groups, with an increase from 451 ± 177 mm³ to 508 ± 192 mm³ (p = 0.001) in Group 1 and from 456 ± 188 mm³ to 509 ± 170 mm³ (p = 0.001) in Group 2. There were no significant differences between the groups in terms of absolute volume increase (58 mm³ versus 53 mm³, respectively; p = 0.65) or in relative volume increase (14% versus 20%, respectively; p = 0.69).CONCLUSIONS:Administration of nitroglycerin plus verapamil or verapamil alone to the radial artery resulted in similar increases in arterial lumen volume according to ECOC-RF IVUS measurements. %K radial %K vasodilator treatment %K percutaneous coronary intervention %K IVUS %K volumetric IVUS analysis %P 401-404