Clementine Decamps, Alexis Arnaud, Florent Petitprez, Mira Ayadi, Aurelia Baures, Lucile Armenoult, et al. (2021). DECONbench: a benchmarking platform dedicated to deconvolution methods for tumor heterogeneity quantification. BMC Bioinformatics, 22, 473.
Abstract: Quantification of tumor heterogeneity is essential to better understand cancer progression and to adapt therapeutic treatments to patient specificities. Bioinformatic tools to assess the different cell populations from single-omic datasets as bulk transcriptome or methylome samples have been recently developed, including reference-based and reference-free methods. Improved methods using multi-omic datasets are yet to be developed in the future and the community would need systematic tools to perform a comparative evaluation of these algorithms on controlled data.