Abstract: Multiple Instance Learning (MIL) has become a hot topic and many different algorithms have been proposed in the last years. Despite this fact, there is a lack of comparative studies that shed light into the characteristics of the different methods and their behavior in different scenarios. In this paper we provide such an analysis. We include methods from different families, and pay special attention to vocabulary-based approaches, a new family of methods that has not received much attention in the MIL literature. The empirical comparison includes seven databases from four heterogeneous domains, implementations of eight popular MIL methods, and a study of the behavior under synthetic conditions. Based on this analysis, we show that, with an appropriate implementation, vocabulary-based approaches outperform other MIL methods in most of the cases, showing in general a more consistent performance.