Abstract: The purpose of this study was to assess whether age-related chromatic sensitivity changes are associated with corresponding changes in hue perception in a large sample of colour-normal observers over a wide age range (n = 185; age range: 18-75 years). In these observers we determined both the sensitivity along the protan, deutan and tritan line; and settings for the four unique hues, from which the characteristics of the higher-order colour mechanisms can be derived. We found a significant decrease in chromatic sensitivity due to ageing, in particular along the tritan line. From the unique hue settings we derived the cone weightings associated with the colour mechanisms that are at equilibrium for the four unique hues. We found that the relative cone weightings (w(L) /w(M) and w(L) /w(S)) associated with the unique hues were independent of age. Our results are consistent with previous findings that the unique hues are rather constant with age while chromatic sensitivity declines. They also provide evidence in favour of the hypothesis that higher-order colour mechanisms are equipped with flexible cone weightings, as opposed to fixed weights. The mechanism underlying this compensation is still poorly understood.

Abstract: Outlier detection is essential for optimal performance of machine learning methods and statistical predictive models. Their detection is especially determinant in small sample size unbalanced problems, since in such settings outliers become highly influential and significantly bias models. This particular experimental settings are usual in medical applications, like diagnosis of rare pathologies, outcome of experimental personalized treatments or pandemic emergencies. In contrast to population-based methods, neighborhood based local approaches compute an outlier score from the neighbors of each sample, are simple flexible methods that have the potential to perform well in small sample size unbalanced problems. A main concern of local approaches is the impact that the computation of each sample neighborhood has on the method performance. Most approaches use a distance in the feature space to define a single neighborhood that requires careful selection of several parameters, like the number of neighbors.
This work presents a local approach based on a local measure of the heterogeneity of sample labels in the feature space considered as a topological manifold. Topology is computed using the communities of a weighted graph codifying mutual nearest neighbors in the feature space. This way, we provide with a set of multiple neighborhoods able to describe the structure of complex spaces without parameter fine tuning. The extensive experiments on real-world and synthetic data sets show that our approach outperforms, both, local and global strategies in multi and single view settings.