Abstract: Nucleus accumbens has been reported as a key structure in the neurobiology of schizophrenia. Studies analyzing structural abnormalities have shown conflicting results, possibly related to confounding factors. We investigated the nucleus accumbens volume using manual delimitation in first-episode psychosis (FEP) controlling for age, cannabis use and medication. Thirty-one FEP subjects who were naive or minimally exposed to antipsychotics and a control group were MRI scanned and clinically assessed from baseline to 6 months of follow-up. FEP showed increased relative and total accumbens volumes. Clinical correlations with negative symptoms, duration of untreated psychosis and cannabis use were not significant.

Abstract: This paper introduces the use of single-layer and deep convolutional networks for remote sensing data analysis. Direct application to multi- and hyperspectral imagery of supervised (shallow or deep) convolutional networks is very challenging given the high input data dimensionality and the relatively small amount of available labeled data. Therefore, we propose the use of greedy layerwise unsupervised pretraining coupled with a highly efficient algorithm for unsupervised learning of sparse features. The algorithm is rooted on sparse representations and enforces both population and lifetime sparsity of the extracted features, simultaneously. We successfully illustrate the expressive power of the extracted representations in several scenarios: classification of aerial scenes, as well as land-use classification in very high resolution or land-cover classification from multi- and hyperspectral images. The proposed algorithm clearly outperforms standard principal component analysis (PCA) and its kernel counterpart (kPCA), as well as current state-of-the-art algorithms of aerial classification, while being extremely computationally efficient at learning representations of data. Results show that single-layer convolutional networks can extract powerful discriminative features only when the receptive field accounts for neighboring pixels and are preferred when the classification requires high resolution and detailed results. However, deep architectures significantly outperform single-layer variants, capturing increasing levels of abstraction and complexity throughout the feature hierarchy.

Abstract: In this paper, we propose an automatic method for constructing an active shape model (ASM) to segment the complete cardiac left ventricle in 3D ultrasound (3DUS) images, which avoids costly manual landmarking. The automatic construction of the ASM has already been addressed in the literature; however, the direct application of these methods to 3DUS is hampered by a high level of noise and artefacts. Therefore, we propose to construct the ASM by fusing the multidetector computed tomography data, to learn the shape, with the artificially generated 3DUS, in order to learn the neighbourhood of the boundaries. Our artificial images were generated by two approaches: a faster one that does not take into account the geometry of the transducer, and a more comprehensive one, implemented in Field II toolbox. The segmentation accuracy of our ASM was evaluated on 20 patients with left-ventricular asynchrony, demonstrating plausibility of the approach.