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Mireia Sole, Joan Blanco, Debora Gil, Oliver Valero, G. Fonseka, M. Lawrie, et al. (2017). "Chromosome Territories in Mice Spermatogenesis: A new three-dimensional methodology of study " In 11th European CytoGenesis Conference.
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Carles Sanchez, Debora Gil, T. Gache, N. Koufos, Marta Diez-Ferrer, & Antoni Rosell. (2016). "SENSA: a System for Endoscopic Stenosis Assessment " In 28th Conference of the international Society for Medical Innovation and Technology.
Abstract: Documenting the severity of a static or dynamic Central Airway Obstruction (CAO) is crucial to establish proper diagnosis and treatment, predict possible treatment effects and better follow-up the patients. The subjective visual evaluation of a stenosis during video-bronchoscopy still remains the most common way to assess a CAO in spite of a consensus among experts for a need to standardize all calculations [1].
The Computer Vision Center in cooperation with the «Hospital de Bellvitge», has developed a System for Endoscopic Stenosis Assessment (SENSA), which computes CAO directly by analyzing standard bronchoscopic data without the need of using other imaging tecnologies.
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Carles Sanchez, Antonio Esteban Lansaque, Agnes Borras, Marta Diez-Ferrer, Antoni Rosell, & Debora Gil. (2017). "Towards a Videobronchoscopy Localization System from Airway Centre Tracking " In 12th International Conference on Computer Vision Theory and Applications (pp. 352–359).
Abstract: Bronchoscopists use fluoroscopy to guide flexible bronchoscopy to the lesion to be biopsied without any kind of incision. Being fluoroscopy an imaging technique based on X-rays, the risk of developmental problems and cancer is increased in those subjects exposed to its application, so minimizing radiation is crucial. Alternative guiding systems such as electromagnetic navigation require specific equipment, increase the cost of the clinical procedure and still require fluoroscopy. In this paper we propose an image based guiding system based on the extraction of airway centres from intra-operative videos. Such anatomical landmarks are matched to the airway centreline extracted from a pre-planned CT to indicate the best path to the nodule. We present a
feasibility study of our navigation system using simulated bronchoscopic videos and a multi-expert validation of landmarks extraction in 3 intra-operative ultrathin explorations.
Keywords: Video-bronchoscopy; Lung cancer diagnosis; Airway lumen detection; Region tracking; Guided bronchoscopy navigation
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Mireia Sole, Joan Blanco, Debora Gil, G. Fonseka, Richard Frodsham, Oliver Valero, et al. (2017). "Is there a pattern of Chromosome territoriality along mice spermatogenesis? " In 3rd Spanish MeioNet Meeting Abstract Book (pp. 55–56).
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Mireia Sole, Joan Blanco, Debora Gil, G. Fonseka, Richard Frodsham, Oliver Valero, et al. (2017)." Unraveling the enigmas of chromosome territoriality during spermatogenesis" In IX Jornada del Departament de Biologia Cel•lular, Fisiologia i Immunologia.
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Rosa Maria Ortiz, Debora Gil, Elisa Minchole, Marta Diez-Ferrer, & Noelia Cubero de Frutos. (2017). "Classification of Confolcal Endomicroscopy Patterns for Diagnosis of Lung Cancer " In 18th World Conference on Lung Cancer.
Abstract: Confocal Laser Endomicroscopy (CLE) is an emerging imaging technique that allows the in-vivo acquisition of cell patterns of potentially malignant lesions. Such patterns could discriminate between inflammatory and neoplastic lesions and, thus, serve as a first in-vivo biopsy to discard cases that do not actually require a cell biopsy.
The goal of this work is to explore whether CLE images obtained during videobronchoscopy contain enough visual information to discriminate between benign and malign peripheral lesions for lung cancer diagnosis. To do so, we have performed a pilot comparative study with 12 patients (6 adenocarcinoma and 6 benign-inflammatory) using 2 different methods for CLE pattern analysis: visual analysis by 3 experts and a novel methodology that uses graph methods to find patterns in pre-trained feature spaces. Our preliminary results indicate that although visual analysis can only achieve a 60.2% of accuracy, the accuracy of the proposed unsupervised image pattern classification raises to 84.6%.
We conclude that CLE images visual information allow in-vivo detection of neoplastic lesions and graph structural analysis applied to deep-learning feature spaces can achieve competitive results.
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Debora Gil, Aura Hernandez-Sabate, David Castells, & Jordi Carrabina. (2017). "CYBERH: Cyber-Physical Systems in Health for Personalized Assistance " In International Symposium on Symbolic and Numeric Algorithms for Scientific Computing.
Abstract: Assistance systems for e-Health applications have some specific requirements that demand of new methods for data gathering, analysis and modeling able to deal with SmallData:
1) systems should dynamically collect data from, both, the environment and the user to issue personalized recommendations; 2) data analysis should be able to tackle a limited number of samples prone to include non-informative data and possibly evolving in time due to changes in patient condition; 3) algorithms should run in real time with possibly limited computational resources and fluctuant internet access.
Electronic medical devices (and CyberPhysical devices in general) can enhance the process of data gathering and analysis in several ways: (i) acquiring simultaneously multiple sensors data instead of single magnitudes (ii) filtering data; (iii) providing real-time implementations condition by isolating tasks in individual processors of multiprocessors Systems-on-chip (MPSoC) platforms and (iv) combining information through sensor fusion
techniques.
Our approach focus on both aspects of the complementary role of CyberPhysical devices and analysis of SmallData in the process of personalized models building for e-Health applications. In particular, we will address the design of Cyber-Physical Systems in Health for Personalized Assistance (CyberHealth) in two specific application cases: 1) A Smart Assisted Driving System (SADs) for dynamical assessment of the driving capabilities of Mild Cognitive Impaired (MCI) people; 2) An Intelligent Operating Room (iOR) for improving the yield of bronchoscopic interventions for in-vivo lung cancer diagnosis.
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Debora Gil, & Guillermo Torres. (2020). "A multi-shape loss function with adaptive class balancing for the segmentation of lung structures " In 34th International Congress and Exhibition on Computer Assisted Radiology & Surgery.
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Debora Gil, Oriol Ramos Terrades, & Raquel Perez. (2020). "Topological Radiomics (TOPiomics): Early Detection of Genetic Abnormalities in Cancer Treatment Evolution " In Women in Geometry and Topology.
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Guillermo Torres, Debora Gil, Antoni Rosell, S. Mena, & Carles Sanchez. (2023)." Virtual Radiomics Biopsy for the Histological Diagnosis of Pulmonary Nodules" In 37th International Congress and Exhibition is organized by Computer Assisted Radiology and Surgery.
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