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Jaume Garcia, Debora Gil, Francesc Carreras, Sandra Pujades, & R.Leta. (2007). "Modelització 4-Dimensional de la Funció Siatólica del Ventricle Esquerre " In XIX Congrés de la Societat Catalana de Cardiologia de Barcelona (pp. 133–134). Barcelona (Spain).
Abstract: L’evolució tecnològica en el tractament de les imatges mèdiques permet reconstruir, amb el software apropiat, imatges tridimensionals de les estructures cardiovasculars i dotar-les de moviment. Les imatges 4D resultants faciliten l’estudi de la fisiopatologia de la insuficiència cardíaca en base als transtorns de l’activació electromecànica ventricular, el que pot ser d’interès en el procés de selecció de pacients candidats a teràpies de resincronització. Presentem els resultats preliminars de la reconstrucció 4D del ventricle esquerre (VE) a partir de les seqüències de tagging miocàrdic del VE.
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Misael Rosales, Petia Radeva, Oriol Rodriguez-Leon, & Debora Gil. (2009). "Modelling of image-catheter motion for 3-D IVUS " . Medical image analysis, 13(1), 91–104.
Abstract: Three-dimensional intravascular ultrasound (IVUS) allows to visualize and obtain volumetric measurements of coronary lesions through an exploration of the cross sections and longitudinal views of arteries. However, the visualization and subsequent morpho-geometric measurements in IVUS longitudinal cuts are subject to distortion caused by periodic image/vessel motion around the IVUS catheter. Usually, to overcome the image motion artifact ECG-gating and image-gated approaches are proposed, leading to slowing the pullback acquisition or disregarding part of IVUS data. In this paper, we argue that the image motion is due to 3-D vessel geometry as well as cardiac dynamics, and propose a dynamic model based on the tracking of an elliptical vessel approximation to recover the rigid transformation and align IVUS images without loosing any IVUS data. We report an extensive validation with synthetic simulated data and in vivo IVUS sequences of 30 patients achieving an average reduction of the image artifact of 97% in synthetic data and 79% in real-data. Our study shows that IVUS alignment improves longitudinal analysis of the IVUS data and is a necessary step towards accurate reconstruction and volumetric measurements of 3-D IVUS.
Keywords: Intravascular ultrasound (IVUS); Motion estimation; Motion decomposition; Fourier
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Josefina Mauri, Eduard Fernandez-Nofrerias, B. Garcia del Blanco, E. Iraculis, J.A. Gomez-Hospital, J. Comin, et al. (2000)." Moviment del vas en l anàlisi d imatges d ecografia intracoronària: un model matemàtic" In Congrés de la Societat Catalana de Cardiologia..
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Ferran Poveda, Debora Gil, & Enric Marti. (2012). "Multi-resolution DT-MRI cardiac tractography " In Statistical Atlases And Computational Models Of The Heart: Imaging and Modelling Challenges (Vol. 7746, pp. 270–277). Springer Berlin Heidelberg.
Abstract: Even using objective measures from DT-MRI no consensus about myocardial architecture has been achieved so far. Streamlining provides good reconstructions at low level of detail, but falls short to give global abstract interpretations. In this paper, we present a multi-resolution methodology that is able to produce simplified representations of cardiac architecture. Our approach produces a reduced set of tracts that are representative of the main geometric features of myocardial anatomical structure. Experiments show that fiber geometry is preserved along reductions, which validates the simplified model for interpretation of cardiac architecture.
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Sergio Vera, Debora Gil, Antonio Lopez, & Miguel Angel Gonzalez Ballester. (2012). "Multilocal Creaseness Measure " . The Insight Journal, .
Abstract: This document describes the implementation using the Insight Toolkit of an algorithm for detecting creases (ridges and valleys) in N-dimensional images, based on the Local Structure Tensor of the image. In addition to the filter used to calculate the creaseness image, a filter for the computation of the structure tensor is also included in this submission.
Keywords: Ridges, Valley, Creaseness, Structure Tensor, Skeleton,
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David Roche, Debora Gil, & Jesus Giraldo. (2013). "Multiple active receptor conformation, agonist efficacy and maximum effect of the system: the conformation-based operational model of agonism, " . Drug Discovery Today, 18(7-8), 365–371.
Abstract: The operational model of agonism assumes that the maximum effect a particular receptor system can achieve (the Em parameter) is fixed. Em estimates are above but close to the asymptotic maximum effects of endogenous agonists. The concept of Em is contradicted by superagonists and those positive allosteric modulators that significantly increase the maximum effect of endogenous agonists. An extension of the operational model is proposed that assumes that the Em parameter does not necessarily have a single value for a receptor system but has multiple values associated to multiple active receptor conformations. The model provides a mechanistic link between active receptor conformation and agonist efficacy, which can be useful for the analysis of agonist response under different receptor scenarios.
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Ferran Poveda, Debora Gil, Albert Andaluz, & Enric Marti. (2011). "Multiscale Tractography for Representing Heart Muscular Architecture " In In MICCAI 2011 Workshop on Computational Diffusion MRI.
Abstract: Deep understanding of myocardial structure of the heart would unravel crucial knowledge for clinical and medical procedures. Although the muscular architecture of the heart has been debated by countless researchers, the controversy is still alive. Diffusion Tensor MRI, DT-MRI, is a unique imaging technique for computational validation of the muscular structure of the heart. By the complex arrangement of myocites, existing techniques can not provide comprehensive descriptions of the global muscular architecture. In this paper we introduce a multiresolution reconstruction technique based on DT-MRI streamlining for simplified global myocardial model generation. Our reconstructions can restore the most complex myocardial structures and indicate a global helical organization
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Debora Gil, Oriol Rodriguez-Leon, Petia Radeva, & Josepa Mauri. (2008). "Myocardial Perfusion Characterization From Contrast Angiography Spectral Distribution " . IEEE Transactions on Medical Imaging, 27(5), 641–649.
Abstract: Despite recovering a normal coronary flow after acute myocardial infarction, percutaneous coronary intervention does not guarantee a proper perfusion (irrigation) of the infarcted area. This damage in microcirculation integrity may detrimentally affect the patient survival. Visual assessment of the myocardium opacification in contrast angiography serves to define a subjective score of the microcirculation integrity myocardial blush analysis (MBA). Although MBA correlates with patient prognosis its visual assessment is a very difficult task that requires of a highly expertise training in order to achieve a good intraobserver and interobserver agreement. In this paper, we provide objective descriptors of the myocardium staining pattern by analyzing the spectrum of the image local statistics. The descriptors proposed discriminate among the different phenomena observed in the angiographic sequence and allow defining an objective score of the myocardial perfusion.
Keywords: Contrast angiography; myocardial perfusion; spectral analysis.
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Albert Andaluz, Francesc Carreras, Cristina Santa Marta, & Debora Gil. (2012). "Myocardial torsion estimation with Tagged-MRI in the OsiriX platform " In Wiro Niessen(Erasmus MC) and Marc Modat(UCL) (Ed.), ISBI Workshop on Open Source Medical Image Analysis software. IEEE.
Abstract: Myocardial torsion (MT) plays a crucial role in the assessment of the functionality of the
left ventricle. For this purpose, the IAM group at the CVC has developed the Harmonic Phase Flow (HPF) plugin for the Osirix DICOM platform . We have validated its funcionalty on sequences acquired using different protocols and including healthy and pathological cases. Results show similar torsion trends for SPAMM acquisitions, with pathological cases introducing expected deviations from the ground truth. Finally, we provide the plugin free of charge at http://iam.cvc.uab.es
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Carles Sanchez, Debora Gil, Jorge Bernal, F. Javier Sanchez, Marta Diez-Ferrer, & Antoni Rosell. (2016). "Navigation Path Retrieval from Videobronchoscopy using Bronchial Branches " In 19th International Conference on Medical Image Computing and Computer Assisted Intervention Workshops (Vol. 9401, pp. 62–70).
Abstract: Bronchoscopy biopsy can be used to diagnose lung cancer without risking complications of other interventions like transthoracic needle aspiration. During bronchoscopy, the clinician has to navigate through the bronchial tree to the target lesion. A main drawback is the difficulty to check whether the exploration is following the correct path. The usual guidance using fluoroscopy implies repeated radiation of the clinician, while alternative systems (like electromagnetic navigation) require specific equipment that increases intervention costs. We propose to compute the navigated path using anatomical landmarks extracted from the sole analysis of videobronchoscopy images. Such landmarks allow matching the current exploration to the path previously planned on a CT to indicate clinician whether the planning is being correctly followed or not. We present a feasibility study of our landmark based CT-video matching using bronchoscopic videos simulated on a virtual bronchoscopy interactive interface.
Keywords: Bronchoscopy navigation; Lumen center; Brochial branches; Navigation path; Videobronchoscopy
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