| Home | << 1 >> |
|
| Record | |||||
|---|---|---|---|---|---|
Author  |
Frederic Sampedro; Anna Domenech; Sergio Escalera; Ignasi Carrio | ||||
| Title | Deriving global quantitative tumor response parameters from 18F-FDG PET-CT scans in patients with non-Hodgkins lymphoma | Type | Journal Article | ||
| Year | 2015 | Publication | Nuclear Medicine Communications | Abbreviated Journal | NMC |
| Volume | 36 | Issue | 4 | Pages | 328-333 |
| Keywords | |||||
| Abstract | OBJECTIVES:
The aim of the study was to address the need for quantifying the global cancer time evolution magnitude from a pair of time-consecutive positron emission tomography-computed tomography (PET-CT) scans. In particular, we focus on the computation of indicators using image-processing techniques that seek to model non-Hodgkin's lymphoma (NHL) progression or response severity. MATERIALS AND METHODS: A total of 89 pairs of time-consecutive PET-CT scans from NHL patients were stored in a nuclear medicine station for subsequent analysis. These were classified by a consensus of nuclear medicine physicians into progressions, partial responses, mixed responses, complete responses, and relapses. The cases of each group were ordered by magnitude following visual analysis. Thereafter, a set of quantitative indicators designed to model the cancer evolution magnitude within each group were computed using semiautomatic and automatic image-processing techniques. Performance evaluation of the proposed indicators was measured by a correlation analysis with the expert-based visual analysis. RESULTS: The set of proposed indicators achieved Pearson's correlation results in each group with respect to the expert-based visual analysis: 80.2% in progressions, 77.1% in partial response, 68.3% in mixed response, 88.5% in complete response, and 100% in relapse. In the progression and mixed response groups, the proposed indicators outperformed the common indicators used in clinical practice [changes in metabolic tumor volume, mean, maximum, peak standardized uptake value (SUV mean, SUV max, SUV peak), and total lesion glycolysis] by more than 40%. CONCLUSION: Computing global indicators of NHL response using PET-CT imaging techniques offers a strong correlation with the associated expert-based visual analysis, motivating the future incorporation of such quantitative and highly observer-independent indicators in oncological decision making or treatment response evaluation scenarios. |
||||
| Address | |||||
| Corporate Author | Thesis | ||||
| Publisher | Place of Publication | Editor | |||
| Language | Summary Language | Original Title | |||
| Series Editor | Series Title | Abbreviated Series Title | |||
| Series Volume | Series Issue | Edition | |||
| ISSN | ISBN | Medium | |||
| Area | Expedition | Conference | |||
| Notes | HuPBA;MILAB | Approved | no | ||
| Call Number | Admin @ si @ SDE2015 | Serial | 2605 | ||
| Permanent link to this record | |||||