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Author (up) Frederic Sampedro; Anna Domenech; Sergio Escalera edit  url
  Title Obtaining quantitative global tumoral state indicators based on whole-body PET/CT scans: A breast cancer case study Type Journal Article
  Year 2014 Publication Nuclear Medicine Communications Abbreviated Journal NMC  
  Volume 35 Issue 4 Pages 362-371  
  Abstract Objectives: In this work we address the need for the computation of quantitative global tumoral state indicators from oncological whole-body PET/computed tomography scans. The combination of such indicators with other oncological information such as tumor markers or biopsy results would prove useful in oncological decision-making scenarios.

Materials and methods: From an ordering of 100 breast cancer patients on the basis of oncological state through visual analysis by a consensus of nuclear medicine specialists, a set of numerical indicators computed from image analysis of the PET/computed tomography scan is presented, which attempts to summarize a patient’s oncological state in a quantitative manner taking into consideration the total tumor volume, aggressiveness, and spread.

Results: Results obtained by comparative analysis of the proposed indicators with respect to the experts’ evaluation show up to 87% Pearson’s correlation coefficient when providing expert-guided PET metabolic tumor volume segmentation and 64% correlation when using completely automatic image analysis techniques.

Conclusion: Global quantitative tumor information obtained by whole-body PET/CT image analysis can prove useful in clinical nuclear medicine settings and oncological decision-making scenarios. The completely automatic computation of such indicators would improve its impact as time efficiency and specialist independence would be achieved.
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  Publisher Place of Publication Editor  
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  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes HuPBA;MILAB Approved no  
  Call Number SDE2014a Serial 2444  
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