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Author Antoni Rosell; Sonia Baeza; S. Garcia-Reina; JL. Mate; Ignasi Guasch; I. Nogueira; I. Garcia-Olive; Guillermo Torres; Carles Sanchez; Debora Gil edit  openurl
  Title Radiomics to increase the effectiveness of lung cancer screening programs. Radiolung preliminary results. Type Journal Article
  Year 2022 Publication European Respiratory Journal Abbreviated Journal ERJ  
  Volume 60 Issue 66 Pages  
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  Notes IAM Approved no  
  Call Number (up) Admin @ si @ RBG2022c Serial 3835  
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Author Esmitt Ramirez; Carles Sanchez; Agnes Borras; Marta Diez-Ferrer; Antoni Rosell; Debora Gil edit   pdf
url  openurl
  Title BronchoX: bronchoscopy exploration software for biopsy intervention planning Type Journal
  Year 2018 Publication Healthcare Technology Letters Abbreviated Journal HTL  
  Volume 5 Issue 5 Pages 177–182  
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  Abstract Virtual bronchoscopy (VB) is a non-invasive exploration tool for intervention planning and navigation of possible pulmonary lesions (PLs). A VB software involves the location of a PL and the calculation of a route, starting from the trachea, to reach it. The selection of a VB software might be a complex process, and there is no consensus in the community of medical software developers in which is the best-suited system to use or framework to choose. The authors present Bronchoscopy Exploration (BronchoX), a VB software to plan biopsy interventions that generate physician-readable instructions to reach the PLs. The authors’ solution is open source, multiplatform, and extensible for future functionalities, designed by their multidisciplinary research and development group. BronchoX is a compound of different algorithms for segmentation, visualisation, and navigation of the respiratory tract. Performed results are a focus on the test the effectiveness of their proposal as an exploration software, also to measure its accuracy as a guiding system to reach PLs. Then, 40 different virtual planning paths were created to guide physicians until distal bronchioles. These results provide a functional software for BronchoX and demonstrate how following simple instructions is possible to reach distal lesions from the trachea.  
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  Notes IAM; 600.096; 600.075; 601.323; 601.337; 600.145 Approved no  
  Call Number (up) Admin @ si @ RSB2018a Serial 3132  
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Author Mireia Sole; Joan Blanco; Debora Gil; G. Fonseka; Richard Frodsham; Francesca Vidal; Zaida Sarrate edit   pdf
isbn  openurl
  Title Noves perspectives en l estudi de la territorialitat cromosomica de cel·lules germinals masculines: estudis tridimensionals Type Journal
  Year 2017 Publication Biologia de la Reproduccio Abbreviated Journal JBR  
  Volume 15 Issue Pages 73-78  
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  Abstract In somatic cells, chromosomes occupy specific nuclear regions called chromosome territories which are involved in the
maintenance and regulation of the genome. Preliminary data in male germ cells also suggest the importance of chromosome
territoriality in cell functionality. Nevertheless, the specific characteristics of testicular tissue (presence of different
cell types with different morphological characteristics, in different stages of development and with different ploidy)
makes difficult to achieve conclusive results. In this study we have developed a methodology to approach the threedimensional
study of all chromosome territories in male germ cells from C57BL/6J mice (Mus musculus). The method
includes the following steps: i) Optimized cell fixation to obtain an optimal preservation of the three-dimensionality cell
morphology, ii) Chromosome identification by FISH (Chromoprobe Multiprobe® OctoChrome™ Murine System; Cytocell)
and confocal microscopy (TCS-SP5, Leica Microsystems), iii) Cell type identification by immunofluorescence
iv) Image analysis using Matlab scripts, v) Numerical data extraction related to chromosome features, chromosome
radial position and chromosome relative position. This methodology allows the unequivocally identification and the
analysis of the chromosome territories of all spermatogenic stages. Results will provide information about the features
that determine chromosomal position, preferred associations between chromosomes, and the relationship between chromosome
positioning and genome regulation.
 
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  ISSN ISBN 978-84-697-3767-5 Medium  
  Area Expedition Conference  
  Notes IAM; 600.096; 600.145 Approved no  
  Call Number (up) Admin @ si @ SBG2017c Serial 2961  
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Author Mireia Sole; Joan Blanco; Debora Gil; G. Fonseka; Richard Frodsham; Oliver Valero; Francesca Vidal; Zaida Sarrate edit  openurl
  Title Análisis 3d de la territorialidad cromosómica en células espermatogénicas: explorando la infertilidad desde un nuevo prisma Type Journal
  Year 2017 Publication Revista Asociación para el Estudio de la Biología de la Reproducción Abbreviated Journal ASEBIR  
  Volume 22 Issue 2 Pages 105  
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  Notes IAM; 600.096; 600.145 Approved no  
  Call Number (up) Admin @ si @ SBG2017d Serial 3042  
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Author Mireia Sole; Joan Blanco; Debora Gil; Oliver Valero; Alvaro Pascual; B. Cardenas; G. Fonseka; E. Anton; Richard Frodsham; Francesca Vidal; Zaida Sarrate edit  url
openurl 
  Title Chromosomal positioning in spermatogenic cells is influenced by chromosomal factors associated with gene activity, bouquet formation, and meiotic sex-chromosome inactivation Type Journal Article
  Year 2021 Publication Chromosoma Abbreviated Journal  
  Volume 130 Issue Pages 163-175  
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  Abstract Chromosome territoriality is not random along the cell cycle and it is mainly governed by intrinsic chromosome factors and gene expression patterns. Conversely, very few studies have explored the factors that determine chromosome territoriality and its influencing factors during meiosis. In this study, we analysed chromosome positioning in murine spermatogenic cells using three-dimensionally fluorescence in situ hybridization-based methodology, which allows the analysis of the entire karyotype. The main objective of the study was to decipher chromosome positioning in a radial axis (all analysed germ-cell nuclei) and longitudinal axis (only spermatozoa) and to identify the chromosomal factors that regulate such an arrangement. Results demonstrated that the radial positioning of chromosomes during spermatogenesis was cell-type specific and influenced by chromosomal factors associated to gene activity. Chromosomes with specific features that enhance transcription (high GC content, high gene density and high numbers of predicted expressed genes) were preferentially observed in the inner part of the nucleus in virtually all cell types. Moreover, the position of the sex chromosomes was influenced by their transcriptional status, from the periphery of the nucleus when its activity was repressed (pachytene) to a more internal position when it is partially activated (spermatid). At pachytene, chromosome positioning was also influenced by chromosome size due to the bouquet formation. Longitudinal chromosome positioning in the sperm nucleus was not random either, suggesting the importance of ordered longitudinal positioning for the release and activation of the paternal genome after fertilisation.  
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  Notes IAM; 600.145 Approved no  
  Call Number (up) Admin @ si @ SBG2021 Serial 3592  
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Author Mireia Sole; Joan Blanco; Debora Gil; Oliver Valero; B. Cardenas; G. Fonseka; E. Anton; Alvaro Pascual; Richard Frodsham; Zaida Sarrate edit  doi
openurl 
  Title Time to match; when do homologous chromosomes become closer? Type Journal Article
  Year 2022 Publication Chromosoma Abbreviated Journal CHRO  
  Volume Issue Pages  
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  Abstract In most eukaryotes, pairing of homologous chromosomes is an essential feature of meiosis that ensures homologous recombination and segregation. However, when the pairing process begins, it is still under investigation. Contrasting data exists in Mus musculus, since both leptotene DSB-dependent and preleptotene DSB-independent mechanisms have been described. To unravel this contention, we examined homologous pairing in pre-meiotic and meiotic Mus musculus cells using a threedimensional fuorescence in situ hybridization-based protocol, which enables the analysis of the entire karyotype using DNA painting probes. Our data establishes in an unambiguously manner that 73.83% of homologous chromosomes are already paired at premeiotic stages (spermatogonia-early preleptotene spermatocytes). The percentage of paired homologous chromosomes increases to 84.60% at mid-preleptotene-zygotene stage, reaching 100% at pachytene stage. Importantly, our results demonstrate a high percentage of homologous pairing observed before the onset of meiosis; this pairing does not occur randomly, as the percentage was higher than that observed in somatic cells (19.47%) and between nonhomologous chromosomes (41.1%). Finally, we have also observed that premeiotic homologous pairing is asynchronous and independent of the chromosome size, GC content, or presence of NOR regions.  
  Address August, 2022  
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  Notes IAM; 601.139; 600.145; 600.096 Approved no  
  Call Number (up) Admin @ si @ SBG2022 Serial 3719  
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Author Carles Sanchez; Jorge Bernal; F. Javier Sanchez; Antoni Rosell; Marta Diez-Ferrer; Debora Gil edit   pdf
doi  openurl
  Title Towards On-line Quantification of Tracheal Stenosis from Videobronchoscopy Type Journal Article
  Year 2015 Publication International Journal of Computer Assisted Radiology and Surgery Abbreviated Journal IJCAR  
  Volume 10 Issue 6 Pages 935-945  
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  Notes IAM; MV; 600.075 Approved no  
  Call Number (up) Admin @ si @ SBS2015a Serial 2611  
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Author Carles Sanchez; Oriol Ramos Terrades; Patricia Marquez; Enric Marti; J.Roncaries; Debora Gil edit  doi
openurl 
  Title Automatic evaluation of practices in Moodle for Self Learning in Engineering Type Journal
  Year 2015 Publication Journal of Technology and Science Education Abbreviated Journal JOTSE  
  Volume 5 Issue 2 Pages 97-106  
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  Notes IAM; DAG; 600.075; 600.077 Approved no  
  Call Number (up) Admin @ si @ SRM2015 Serial 2610  
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Author Guillermo Torres; Sonia Baeza; Carles Sanchez; Ignasi Guasch; Antoni Rosell; Debora Gil edit  doi
openurl 
  Title An Intelligent Radiomic Approach for Lung Cancer Screening Type Journal Article
  Year 2022 Publication Applied Sciences Abbreviated Journal APPLSCI  
  Volume 12 Issue 3 Pages 1568  
  Keywords Lung cancer; Early diagnosis; Screening; Neural networks; Image embedding; Architecture optimization  
  Abstract The efficiency of lung cancer screening for reducing mortality is hindered by the high rate of false positives. Artificial intelligence applied to radiomics could help to early discard benign cases from the analysis of CT scans. The available amount of data and the fact that benign cases are a minority, constitutes a main challenge for the successful use of state of the art methods (like deep learning), which can be biased, over-fitted and lack of clinical reproducibility. We present an hybrid approach combining the potential of radiomic features to characterize nodules in CT scans and the generalization of the feed forward networks. In order to obtain maximal reproducibility with minimal training data, we propose an embedding of nodules based on the statistical significance of radiomic features for malignancy detection. This representation space of lesions is the input to a feed
forward network, which architecture and hyperparameters are optimized using own-defined metrics of the diagnostic power of the whole system. Results of the best model on an independent set of patients achieve 100% of sensitivity and 83% of specificity (AUC = 0.94) for malignancy detection.
 
  Address Jan 2022  
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  Notes IAM; 600.139; 600.145 Approved no  
  Call Number (up) Admin @ si @ TBS2022 Serial 3699  
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Author Guillermo Torres; Debora Gil; Antoni Rosell; S. Mena; Carles Sanchez edit  openurl
  Title Virtual Radiomics Biopsy for the Histological Diagnosis of Pulmonary Nodules – Intermediate Results of the RadioLung Project Type Journal Article
  Year 2023 Publication International Journal of Computer Assisted Radiology and Surgery Abbreviated Journal IJCARS  
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  Notes IAM Approved no  
  Call Number (up) Admin @ si @ TGM2023 Serial 3830  
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