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Author David Roche; Debora Gil; Jesus Giraldo edit  doi
isbn  openurl
  Title Mathematical modeling of G protein-coupled receptor function: What can we learn from empirical and mechanistic models? Type Book Chapter
  Year 2014 Publication G Protein-Coupled Receptors – Modeling and Simulation Advances in Experimental Medicine and Biology Abbreviated Journal  
  Volume (up) 796 Issue 3 Pages 159-181  
  Keywords β-arrestin; biased agonism; curve fitting; empirical modeling; evolutionary algorithm; functional selectivity; G protein; GPCR; Hill coefficient; intrinsic efficacy; inverse agonism; mathematical modeling; mechanistic modeling; operational model; parameter optimization; receptor dimer; receptor oligomerization; receptor constitutive activity; signal transduction; two-state model  
  Abstract Empirical and mechanistic models differ in their approaches to the analysis of pharmacological effect. Whereas the parameters of the former are not physical constants those of the latter embody the nature, often complex, of biology. Empirical models are exclusively used for curve fitting, merely to characterize the shape of the E/[A] curves. Mechanistic models, on the contrary, enable the examination of mechanistic hypotheses by parameter simulation. Regretfully, the many parameters that mechanistic models may include can represent a great difficulty for curve fitting, representing, thus, a challenge for computational method development. In the present study some empirical and mechanistic models are shown and the connections, which may appear in a number of cases between them, are analyzed from the curves they yield. It may be concluded that systematic and careful curve shape analysis can be extremely useful for the understanding of receptor function, ligand classification and drug discovery, thus providing a common language for the communication between pharmacologists and medicinal chemists.  
  Address  
  Corporate Author Thesis  
  Publisher Springer Netherlands Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0065-2598 ISBN 978-94-007-7422-3 Medium  
  Area Expedition Conference  
  Notes IAM; 600.075 Approved no  
  Call Number IAM @ iam @ RGG2014 Serial 2197  
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Author Ole Vilhelm-Larsen; Petia Radeva; Enric Marti edit   pdf
doi  openurl
  Title Guidelines for choosing optimal parameters of elasticity for snakes Type Book Chapter
  Year 1995 Publication Computer Analysis Of Images And Patterns Abbreviated Journal LNCS  
  Volume (up) 970 Issue Pages 106-113  
  Keywords  
  Abstract This paper proposes a guidance in the process of choosing and using the parameters of elasticity of a snake in order to obtain a precise segmentation. A new two step procedure is defined based on upper and lower bounds on the parameters. Formulas, by which these bounds can be calculated for real images where parts of the contour may be missing, are presented. Experiments on segmentation of bone structures in X-ray images have verified the usefulness of the new procedure.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Lecture Notes in Computer Science Abbreviated Series Title LNCS  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes MILAB;IAM Approved no  
  Call Number IAM @ iam @ LRM1995b Serial 1558  
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Author Josep Llados; Gemma Sanchez; Enric Marti edit   pdf
doi  openurl
  Title A string based method to recognize symbols and structural textures in architectural plans Type Book Chapter
  Year 1998 Publication Graphics Recognition Algorithms and Systems Second International Workshop, GREC' 97 Nancy, France, August 22–23, 1997 Selected Papers Abbreviated Journal LNCS  
  Volume (up) 1389 Issue 1998 Pages 91-103  
  Keywords  
  Abstract This paper deals with the recognition of symbols and structural textures in architectural plans using string matching techniques. A plan is represented by an attributed graph whose nodes represent characteristic points and whose edges represent segments. Symbols and textures can be seen as a set of regions, i.e. closed loops in the graph, with a particular arrangement. The search for a symbol involves a graph matching between the regions of a model graph and the regions of the graph representing the document. Discriminating a texture means a clustering of neighbouring regions of this graph. Both procedures involve a similarity measure between graph regions. A string codification is used to represent the sequence of outlining edges of a region. Thus, the similarity between two regions is defined in terms of the string edit distance between their boundary strings. The use of string matching allows the recognition method to work also under presence of distortion.  
  Address  
  Corporate Author Thesis  
  Publisher Springer Link Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title LNCS Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes DAG; IAM Approved no  
  Call Number IAM @ iam @ SLE1998 Serial 1573  
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Author Josep Llados; Ernest Valveny; Gemma Sanchez; Enric Marti edit   pdf
url  doi
isbn  openurl
  Title Symbol recognition: current advances and perspectives Type Book Chapter
  Year 2002 Publication Graphics Recognition Algorithms And Applications Abbreviated Journal LNCS  
  Volume (up) 2390 Issue Pages 104-128  
  Keywords  
  Abstract The recognition of symbols in graphic documents is an intensive research activity in the community of pattern recognition and document analysis. A key issue in the interpretation of maps, engineering drawings, diagrams, etc. is the recognition of domain dependent symbols according to a symbol database. In this work we first review the most outstanding symbol recognition methods from two different points of view: application domains and pattern recognition methods. In the second part of the paper, open and unaddressed problems involved in symbol recognition are described, analyzing their current state of art and discussing future research challenges. Thus, issues such as symbol representation, matching, segmentation, learning, scalability of recognition methods and performance evaluation are addressed in this work. Finally, we discuss the perspectives of symbol recognition concerning to new paradigms such as user interfaces in handheld computers or document database and WWW indexing by graphical content.  
  Address London, UK  
  Corporate Author Thesis  
  Publisher Springer-Verlag Place of Publication Editor Dorothea Blostein and Young- Bin Kwon  
  Language Summary Language Original Title  
  Series Editor Series Title Lecture Notes in Computer Science Abbreviated Series Title LNCS  
  Series Volume Series Issue Edition  
  ISSN ISBN 3-540-44066-6 Medium  
  Area Expedition Conference GREC  
  Notes DAG; IAM; Approved no  
  Call Number IAM @ iam @ LVS2002 Serial 1572  
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Author Debora Gil; Petia Radeva edit   pdf
url  doi
isbn  openurl
  Title Curvature Vector Flow to Assure Convergent Deformable Models for Shape Modelling Type Book Chapter
  Year 2003 Publication Energy Minimization Methods In Computer Vision And Pattern Recognition Abbreviated Journal LNCS  
  Volume (up) 2683 Issue Pages 357-372  
  Keywords Initial condition; Convex shape; Non convex analysis; Increase; Segmentation; Gradient; Standard; Standards; Concave shape; Flow models; Tracking; Edge detection; Curvature  
  Abstract Poor convergence to concave shapes is a main limitation of snakes as a standard segmentation and shape modelling technique. The gradient of the external energy of the snake represents a force that pushes the snake into concave regions, as its internal energy increases when new inexion points are created. In spite of the improvement of the external energy by the gradient vector ow technique, highly non convex shapes can not be obtained, yet. In the present paper, we develop a new external energy based on the geometry of the curve to be modelled. By tracking back the deformation of a curve that evolves by minimum curvature ow, we construct a distance map that encapsulates the natural way of adapting to non convex shapes. The gradient of this map, which we call curvature vector ow (CVF), is capable of attracting a snake towards any contour, whatever its geometry. Our experiments show that, any initial snake condition converges to the curve to be modelled in optimal time.  
  Address  
  Corporate Author Thesis  
  Publisher Springer, Berlin Place of Publication Lisbon, PORTUGAL Editor Springer, B.  
  Language Summary Language Original Title  
  Series Editor Series Title Lecture Notes in Computer Science Abbreviated Series Title LNCS  
  Series Volume Series Issue Edition  
  ISSN 0302-9743 ISBN 3-540-40498-8 Medium  
  Area Expedition Conference  
  Notes IAM;MILAB Approved no  
  Call Number IAM @ iam @ GIR2003b Serial 1535  
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Author Misael Rosales; Petia Radeva; Oriol Rodriguez; Debora Gil edit   pdf
doi  openurl
  Title Suppression of IVUS Image Rotation. A Kinematic Approach Type Book Chapter
  Year 2005 Publication Functional Imaging and Modeling of the Heart Abbreviated Journal LNCS  
  Volume (up) 3504 Issue Pages 889-892  
  Keywords  
  Abstract IntraVascular Ultrasound (IVUS) is an exploratory technique used in interventional procedures that shows cross section images of arteries and provides qualitative information about the causes and severity of the arterial lumen narrowing. Cross section analysis as well as visualization of plaque extension in a vessel segment during the catheter imaging pullback are the technique main advantages. However, IVUS sequence exhibits a periodic rotation artifact that makes difficult the longitudinal lesion inspection and hinders any segmentation algorithm. In this paper we propose a new kinematic method to estimate and remove the image rotation of IVUS images sequences. Results on several IVUS sequences show good results and prompt some of the clinical applications to vessel dynamics study, and relation to vessel pathology.  
  Address  
  Corporate Author Thesis  
  Publisher Springer Berlin / Heidelberg Place of Publication Editor Frangi, Alejandro and Radeva, Petia and Santos, Andres and Hernandez, Monica  
  Language Summary Language Original Title  
  Series Editor Series Title Lecture Notes in Computer Science Abbreviated Series Title LNCS  
  Series Volume 3504 Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM;MILAB Approved no  
  Call Number IAM @ iam @ RRR2005 Serial 1645  
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Author F.Guirado; Ana Ripoll; C.Roig; Aura Hernandez-Sabate; Emilio Luque edit   pdf
openurl 
  Title Exploiting Throughput for Pipeline Execution in Streaming Image Processing Applications Type Book Chapter
  Year 2006 Publication Euro-Par 2006 Parallel Processing Abbreviated Journal LNCS  
  Volume (up) 4128 Issue Pages 1095-1105  
  Keywords 12th International Euro–Par Conference  
  Abstract There is a large range of image processing applications that act on an input sequence of image frames that are continuously received. Throughput is a key performance measure to be optimized when execu- ting them. In this paper we propose a new task replication methodology for optimizing throughput for an image processing application in the field of medicine. The results show that by applying the proposed methodo- logy we are able to achieve the desired throughput in all cases, in such a way that the input frames can be processed at any given rate.  
  Address  
  Corporate Author Thesis  
  Publisher Springer-Verlag Berlin Heidelberg Place of Publication Dresden, Germany (European Union) Editor UAB; W, E.N.; et al.  
  Language Summary Language Original Title  
  Series Editor Series Title Lecture Notes In Computer Science Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference Euro–Par  
  Notes IAM Approved no  
  Call Number IAM @ iam @ GRR2006a Serial 1542  
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Author Debora Gil; Oriol Rodriguez-Leon; Petia Radeva; Aura Hernandez-Sabate edit   pdf
doi  isbn
openurl 
  Title Assessing Artery Motion Compensation in IVUS Type Book Chapter
  Year 2007 Publication Computer Analysis Of Images And Patterns Abbreviated Journal LNCS  
  Volume (up) 4673 Issue Pages 213-220  
  Keywords validation standards; quality measures; IVUS motion compensation; conservation laws; Fourier development  
  Abstract Cardiac dynamics suppression is a main issue for visual improvement and computation of tissue mechanical properties in IntraVascular UltraSound (IVUS). Although in recent times several motion compensation techniques have arisen, there is a lack of objective evaluation of motion reduction in in vivo pullbacks. We consider that the assessment protocol deserves special attention for the sake of a clinical applicability as reliable as possible. Our work focuses on defining a quality measure and a validation protocol assessing IVUS motion compensation. On the grounds of continuum mechanics laws we introduce a novel score measuring motion reduction in in vivo sequences. Synthetic experiments validate the proposed score as measure of motion parameters accuracy; while results in in vivo pullbacks show its reliability in clinical cases.  
  Address  
  Corporate Author Thesis  
  Publisher Springerlink Place of Publication Heidelberg Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Lecture Notes in Computer Science Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN 978-3-540-74271-5 Medium  
  Area Expedition Conference  
  Notes IAM;MILAB Approved no  
  Call Number IAM @ iam @ GRR2007 Serial 1540  
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Author Jaume Garcia; Debora Gil; Aura Hernandez-Sabate edit   pdf
doi  openurl
  Title Endowing Canonical Geometries to Cardiac Structures Type Book Chapter
  Year 2010 Publication Statistical Atlases And Computational Models Of The Heart Abbreviated Journal  
  Volume (up) 6364 Issue Pages 124-133  
  Keywords  
  Abstract International conference on Cardiac electrophysiological simulation challenge
In this paper, we show that canonical (shape-based) geometries can be endowed to cardiac structures using tubular coordinates defined over their medial axis. We give an analytic formulation of these geometries by means of B-Splines. Since B-Splines present vector space structure PCA can be applied to their control points and statistical models relating boundaries and the interior of the anatomical structures can be derived. We demonstrate the applicability in two cardiac structures, the 3D Left Ventricular volume, and the 2D Left-Right ventricle set in 2D Short Axis view.
 
  Address  
  Corporate Author Thesis  
  Publisher Springer Berlin / Heidelberg Place of Publication Editor Camara, O.; Pop, M.; Rhode, K.; Sermesant, M.; Smith, N.; Young, A.  
  Language Summary Language Original Title  
  Series Editor Series Title Lecture Notes in Computer Science Abbreviated Series Title LNCS  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM Approved no  
  Call Number IAM @ iam @ GGH2010b Serial 1515  
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Author Sergio Vera; Debora Gil; Agnes Borras; F. Javier Sanchez; Frederic Perez; Marius G. Linguraru; Miguel Angel Gonzalez Ballester edit   pdf
doi  isbn
openurl 
  Title Computation and Evaluation of Medial Surfaces for Shape Representation of Abdominal Organs Type Book Chapter
  Year 2012 Publication Workshop on Computational and Clinical Applications in Abdominal Imaging Abbreviated Journal  
  Volume (up) 7029 Issue Pages 223–230  
  Keywords medial manifolds, abdomen.  
  Abstract Medial representations are powerful tools for describing and parameterizing the volumetric shape of anatomical structures. Existing methods show excellent results when applied to 2D
objects, but their quality drops across dimensions. This paper contributes to the computation of medial manifolds in two aspects. First, we provide a standard scheme for the computation of medial
manifolds that avoid degenerated medial axis segments; second, we introduce an energy based method which performs independently of the dimension. We evaluate quantitatively the performance of our
method with respect to existing approaches, by applying them to synthetic shapes of known medial geometry. Finally, we show results on shape representation of multiple abdominal organs,
exploring the use of medial manifolds for the representation of multi-organ relations.
 
  Address Toronto; Canada;  
  Corporate Author Thesis  
  Publisher Springer Link Place of Publication Berlin Editor H. Yoshida et al  
  Language English Summary Language English Original Title  
  Series Editor Series Title Lecture Notes in Computer Science Abbreviated Series Title LNCS  
  Series Volume Series Issue Edition  
  ISSN 0302-9743 ISBN 978-3-642-28556-1 Medium  
  Area Expedition Conference ABDI  
  Notes IAM;MV Approved no  
  Call Number IAM @ iam @ VGB2012 Serial 1834  
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