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Sonia Baeza; Debora Gil; I.Garcia Olive; M.Salcedo; J.Deportos; Carles Sanchez; Guillermo Torres; G.Moragas; Antoni Rosell |
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Title |
A novel intelligent radiomic analysis of perfusion SPECT/CT images to optimize pulmonary embolism diagnosis in COVID-19 patients |
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Journal Article |
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2022 |
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EJNMMI Physics |
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EJNMMI-PHYS |
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9 |
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1, Article 84 |
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1-17 |
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Background: COVID-19 infection, especially in cases with pneumonia, is associated with a high rate of pulmonary embolism (PE). In patients with contraindications for CT pulmonary angiography (CTPA) or non-diagnostic CTPA, perfusion single-photon emission computed tomography/computed tomography (Q-SPECT/CT) is a diagnostic alternative. The goal of this study is to develop a radiomic diagnostic system to detect PE based only on the analysis of Q-SPECT/CT scans.
Methods: This radiomic diagnostic system is based on a local analysis of Q-SPECT/CT volumes that includes both CT and Q-SPECT values for each volume point. We present a combined approach that uses radiomic features extracted from each scan as input into a fully connected classifcation neural network that optimizes a weighted crossentropy loss trained to discriminate between three diferent types of image patterns (pixel sample level): healthy lungs (control group), PE and pneumonia. Four types of models using diferent confguration of parameters were tested.
Results: The proposed radiomic diagnostic system was trained on 20 patients (4,927 sets of samples of three types of image patterns) and validated in a group of 39 patients (4,410 sets of samples of three types of image patterns). In the training group, COVID-19 infection corresponded to 45% of the cases and 51.28% in the test group. In the test group, the best model for determining diferent types of image patterns with PE presented a sensitivity, specifcity, positive predictive value and negative predictive value of 75.1%, 98.2%, 88.9% and 95.4%, respectively. The best model for detecting
pneumonia presented a sensitivity, specifcity, positive predictive value and negative predictive value of 94.1%, 93.6%, 85.2% and 97.6%, respectively. The area under the curve (AUC) was 0.92 for PE and 0.91 for pneumonia. When the results obtained at the pixel sample level are aggregated into regions of interest, the sensitivity of the PE increases to 85%, and all metrics improve for pneumonia.
Conclusion: This radiomic diagnostic system was able to identify the diferent lung imaging patterns and is a frst step toward a comprehensive intelligent radiomic system to optimize the diagnosis of PE by Q-SPECT/CT. |
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5 dec 2022 |
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Admin @ si @ BGG2022 |
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3759 |
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Author |
Petia Radeva; Enric Marti |
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Title |
Facial Features Segmentation by Model-Based Snakes. |
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Miscellaneous |
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1995 |
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Trobada de Joves Investigadors, IIIA. |
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Bellaterra (Barcelona), Spain |
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MILAB; IAM |
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BCNPCL @ bcnpcl @ RaM1995a |
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130 |
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Jaume Garcia |
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Title |
Propagacio de fronts per a la segmentacio en imatges IVUS |
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2002 |
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Technical Report |
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65 |
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CVC (UAB) |
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IAM @ iam @ Gar2002 |
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328 |
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Author |
Albert Andaluz |
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Title |
LV Contour Segmentation in TMR images using Semantic Description of Tissue and Prior Knowledge Correction |
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2009 |
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CVC Technical Report |
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142 |
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Active Contour Models; Snakes; Active Shape Models; Deformable Templates; Left Ventricle Segmentation; Generalized Orthogonal Procrustes Analysis; Harmonic Phase Flow; Principal Component Analysis; Tagged Magnetic Resonance |
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The Diagnosis of Left Ventricle (LV) pathologies is related to regional wall motion analysis. Health indicator scores such as the rotation and the torsion are useful for the diagnose of the Left Ventricle (LV) function. However, this requires proper identification of LV segments. On one hand, manual segmentation is robust, but it is slow and requires medical expertise. On the other hand, the tag pattern in Tagged Magnetic Resonance (TMR) sequences is a problem for the automatic segmentation of the LV boundaries. Consequently, we propose a method based in the classical formulation of parametric Snakes, combined with Active Shape models. Our semantic definition of the LV is tagged tissue that experiences motion in the systolic cycle. This defines two energy potentials for the Snake convergence. Additionally, the mean shape corrects excessive deviation from the anatomical shape. We have validated our approach in 15 healthy volunteers and two short axis cuts. In this way, we have compared the automatic segmentations to manual shapes outlined by medical experts. Also, we have explored the accuracy of clinical scores computed using automatic contours. The results show minor divergence in the approximation and the manual segmentations as well as robust computation of clinical scores in all cases. From this we conclude that the proposed method is a promising support tool for clinical analysis. |
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Master's thesis |
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Bellaterra 08193, Barcelona, Spain |
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IAM @ iam @ And2009 |
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1667 |
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Debora Gil; Jaume Garcia; Mariano Vazquez; Ruth Aris; Guilleaume Houzeaux |
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Title |
Patient-Sensitive Anatomic and Functional 3D Model of the Left Ventricle Function |
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Conference Article |
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2008 |
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8th World Congress on Computational Mechanichs (WCCM8) |
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Left Ventricle, Electromechanical Models, Image Processing, Magnetic Resonance. |
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Early diagnosis and accurate treatment of Left Ventricle (LV) dysfunction significantly increases the patient survival. Impairment of LV contractility due to cardiovascular diseases is reflected in its motion patterns. Recent advances in medical imaging, such as Magnetic Resonance (MR), have encouraged research on 3D simulation and modelling of the LV dynamics. Most of the existing 3D models [1] consider just the gross anatomy of the LV and restore a truncated ellipse which deforms along the cardiac cycle. The contraction mechanics of any muscle strongly depends on the spatial orientation of its muscular fibers since the motion that the muscle undergoes mainly takes place along the fibers. It follows that such simplified models do not allow evaluation of the heart electro-mechanical function and coupling, which has recently risen as the key point for understanding the LV functionality [2]. In order to thoroughly understand the LV mechanics it is necessary to consider the complete anatomy of the LV given by the orientation of the myocardial fibres in 3D space as described by Torrent Guasp [3].
We propose developing a 3D patient-sensitive model of the LV integrating, for the first time, the ven- tricular band anatomy (fibers orientation), the LV gross anatomy and its functionality. Such model will represent the LV function as a natural consequence of its own ventricular band anatomy. This might be decisive in restoring a proper LV contraction in patients undergoing pace marker treatment.
The LV function is defined as soon as the propagation of the contractile electromechanical pulse has been modelled. In our experiments we have used the wave equation for the propagation of the electric pulse. The electromechanical wave moves on the myocardial surface and should have a conductivity tensor oriented along the muscular fibers. Thus, whatever mathematical model for electric pulse propa- gation [4] we consider, the complete anatomy of the LV should be extracted.
The LV gross anatomy is obtained by processing multi slice MR images recorded for each patient. Information about the myocardial fibers distribution can only be extracted by Diffusion Tensor Imag- ing (DTI), which can not provide in vivo information for each patient. As a first approach, we have
Figure 1: Scheme for the Left Ventricle Patient-Sensitive Model.
computed an average model of fibers from several DTI studies of canine hearts. This rough anatomy is the input for our electro-mechanical propagation model simulating LV dynamics. The average fiber orientation is updated until the simulated LV motion agrees with the experimental evidence provided by the LV motion observed in tagged MR (TMR) sequences. Experimental LV motion is recovered by applying image processing, differential geometry and interpolation techniques to 2D TMR slices [5]. The pipeline in figure 1 outlines the interaction between simulations and experimental data leading to our patient-tailored model. |
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Venice; Italy |
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9788496736559 |
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IAM @ iam @ GGV2008b |
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993 |
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Enric Marti; Ferran Poveda; Antoni Gurgui; Jaume Rocarias; Debora Gil; Aura Hernandez-Sabate |
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Una experiencia de estructura, funcionamiento y evaluación de la asignatura de graficos por computador con metodologia de aprendizaje basado en proyectos |
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2013 |
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IV Congreso Internacional UNIVEST |
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IV Congreso Internacional UNIVEST |
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UNIVEST |
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IAM; ADAS |
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Admin @ si @ MPG2013b |
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2384 |
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Enric Marti; J. Rocarias; A. Sanchez; Petia Radeva; Ricardo Toledo; Jordi Vitria |
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Caronte: una propuesta de entorno de gestion documental para asignaturas de Ingenieria Informatica |
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2006 |
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IV Congreso Internacional Docencia Universitaria e Innovacion (CIDUI´06) |
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IAM;RV;OR;MILAB;ADAS;MV |
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BCNPCL @ bcnpcl @ MRS2006a |
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1122 |
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Enric Marti; Carme Julia; Debora Gil |
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Una experiencia de PBL en la docencia de la asignatura de Graficos por Computador en Ingenieria Informatica |
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IV Congreso Internacional Docencia Universitaria e Innovacion (CIDUI´06) |
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IAM @ iam @ MJG2006b |
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Enric Marti; J. Rocarias; A. Sanchez; Petia Radeva; Ricardo Toledo; Jordi Vitria |
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Caronte: un gestor documental para asignaturas del EEES |
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2006 |
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III Jornades de Innovacio Docent |
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UAB, Bellaterra |
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BCNPCL @ bcnpcl @ MRS2006b |
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1124 |
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Enric Marti; J. Rocarias; Petia Radeva; H. Tizon; Jordi Vitria |
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Caronte. Un gestor documental para asignaturas de universidad en el EEES |
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2007 |
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Desarrollo de gestion de grupos, encuestas y autoevaluacion, MoodleMoot 2007 |
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BCNPCL @ bcnpcl @ MRR2007b |
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1128 |
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