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Author (up) Mireia Sole; Joan Blanco; Debora Gil; Oliver Valero; Alvaro Pascual; B. Cardenas; G. Fonseka; E. Anton; Richard Frodsham; Francesca Vidal; Zaida Sarrate edit  url
openurl 
  Title Chromosomal positioning in spermatogenic cells is influenced by chromosomal factors associated with gene activity, bouquet formation, and meiotic sex-chromosome inactivation Type Journal Article
  Year 2021 Publication Chromosoma Abbreviated Journal  
  Volume 130 Issue Pages 163-175  
  Keywords  
  Abstract Chromosome territoriality is not random along the cell cycle and it is mainly governed by intrinsic chromosome factors and gene expression patterns. Conversely, very few studies have explored the factors that determine chromosome territoriality and its influencing factors during meiosis. In this study, we analysed chromosome positioning in murine spermatogenic cells using three-dimensionally fluorescence in situ hybridization-based methodology, which allows the analysis of the entire karyotype. The main objective of the study was to decipher chromosome positioning in a radial axis (all analysed germ-cell nuclei) and longitudinal axis (only spermatozoa) and to identify the chromosomal factors that regulate such an arrangement. Results demonstrated that the radial positioning of chromosomes during spermatogenesis was cell-type specific and influenced by chromosomal factors associated to gene activity. Chromosomes with specific features that enhance transcription (high GC content, high gene density and high numbers of predicted expressed genes) were preferentially observed in the inner part of the nucleus in virtually all cell types. Moreover, the position of the sex chromosomes was influenced by their transcriptional status, from the periphery of the nucleus when its activity was repressed (pachytene) to a more internal position when it is partially activated (spermatid). At pachytene, chromosome positioning was also influenced by chromosome size due to the bouquet formation. Longitudinal chromosome positioning in the sperm nucleus was not random either, suggesting the importance of ordered longitudinal positioning for the release and activation of the paternal genome after fertilisation.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM; 600.145 Approved no  
  Call Number Admin @ si @ SBG2021 Serial 3592  
Permanent link to this record
 
 
Author (up) Mireia Sole; Joan Blanco; Debora Gil; Oliver Valero; B. Cardenas; G. Fonseka; E. Anton; Alvaro Pascual; Richard Frodsham; Zaida Sarrate edit  doi
openurl 
  Title Time to match; when do homologous chromosomes become closer? Type Journal Article
  Year 2022 Publication Chromosoma Abbreviated Journal CHRO  
  Volume Issue Pages  
  Keywords  
  Abstract In most eukaryotes, pairing of homologous chromosomes is an essential feature of meiosis that ensures homologous recombination and segregation. However, when the pairing process begins, it is still under investigation. Contrasting data exists in Mus musculus, since both leptotene DSB-dependent and preleptotene DSB-independent mechanisms have been described. To unravel this contention, we examined homologous pairing in pre-meiotic and meiotic Mus musculus cells using a threedimensional fuorescence in situ hybridization-based protocol, which enables the analysis of the entire karyotype using DNA painting probes. Our data establishes in an unambiguously manner that 73.83% of homologous chromosomes are already paired at premeiotic stages (spermatogonia-early preleptotene spermatocytes). The percentage of paired homologous chromosomes increases to 84.60% at mid-preleptotene-zygotene stage, reaching 100% at pachytene stage. Importantly, our results demonstrate a high percentage of homologous pairing observed before the onset of meiosis; this pairing does not occur randomly, as the percentage was higher than that observed in somatic cells (19.47%) and between nonhomologous chromosomes (41.1%). Finally, we have also observed that premeiotic homologous pairing is asynchronous and independent of the chromosome size, GC content, or presence of NOR regions.  
  Address August, 2022  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM; 601.139; 600.145; 600.096 Approved no  
  Call Number Admin @ si @ SBG2022 Serial 3719  
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Author (up) Misael Rosales; Petia Radeva; Oriol Rodriguez; Debora Gil edit   pdf
doi  openurl
  Title Suppression of IVUS Image Rotation. A Kinematic Approach Type Book Chapter
  Year 2005 Publication Functional Imaging and Modeling of the Heart Abbreviated Journal LNCS  
  Volume 3504 Issue Pages 889-892  
  Keywords  
  Abstract IntraVascular Ultrasound (IVUS) is an exploratory technique used in interventional procedures that shows cross section images of arteries and provides qualitative information about the causes and severity of the arterial lumen narrowing. Cross section analysis as well as visualization of plaque extension in a vessel segment during the catheter imaging pullback are the technique main advantages. However, IVUS sequence exhibits a periodic rotation artifact that makes difficult the longitudinal lesion inspection and hinders any segmentation algorithm. In this paper we propose a new kinematic method to estimate and remove the image rotation of IVUS images sequences. Results on several IVUS sequences show good results and prompt some of the clinical applications to vessel dynamics study, and relation to vessel pathology.  
  Address  
  Corporate Author Thesis  
  Publisher Springer Berlin / Heidelberg Place of Publication Editor Frangi, Alejandro and Radeva, Petia and Santos, Andres and Hernandez, Monica  
  Language Summary Language Original Title  
  Series Editor Series Title Lecture Notes in Computer Science Abbreviated Series Title LNCS  
  Series Volume 3504 Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM;MILAB Approved no  
  Call Number IAM @ iam @ RRR2005 Serial 1645  
Permanent link to this record
 
 
Author (up) Misael Rosales; Petia Radeva;Oriol Rodriguez-Leon; Debora Gil edit   pdf
doi  openurl
  Title Modelling of image-catheter motion for 3-D IVUS Type Journal Article
  Year 2009 Publication Medical image analysis Abbreviated Journal MIA  
  Volume 13 Issue 1 Pages 91-104  
  Keywords Intravascular ultrasound (IVUS); Motion estimation; Motion decomposition; Fourier  
  Abstract Three-dimensional intravascular ultrasound (IVUS) allows to visualize and obtain volumetric measurements of coronary lesions through an exploration of the cross sections and longitudinal views of arteries. However, the visualization and subsequent morpho-geometric measurements in IVUS longitudinal cuts are subject to distortion caused by periodic image/vessel motion around the IVUS catheter. Usually, to overcome the image motion artifact ECG-gating and image-gated approaches are proposed, leading to slowing the pullback acquisition or disregarding part of IVUS data. In this paper, we argue that the image motion is due to 3-D vessel geometry as well as cardiac dynamics, and propose a dynamic model based on the tracking of an elliptical vessel approximation to recover the rigid transformation and align IVUS images without loosing any IVUS data. We report an extensive validation with synthetic simulated data and in vivo IVUS sequences of 30 patients achieving an average reduction of the image artifact of 97% in synthetic data and 79% in real-data. Our study shows that IVUS alignment improves longitudinal analysis of the IVUS data and is a necessary step towards accurate reconstruction and volumetric measurements of 3-D IVUS.  
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  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM;MILAB Approved no  
  Call Number IAM @ iam @ RRR2009 Serial 1646  
Permanent link to this record
 
 
Author (up) Ole Larsen; Petia Radeva; Enric Marti edit   pdf
doi  openurl
  Title Bounds on the optimal elasticity parameters for a snake Type Journal Article
  Year 1995 Publication Image Analysis and Processing Abbreviated Journal  
  Volume Issue Pages 37-42  
  Keywords  
  Abstract This paper develops a formalism by which an estimate for the upper and lower bounds for the elasticity parameters for a snake can be obtained. Objects different in size and shape give rise to different bounds. The bounds can be obtained based on an analysis of the shape of the object of interest. Experiments on synthetic images show a good correlation between the estimated behaviour of the snake and the one actually observed. Experiments on real X-ray images show that the parameters for optimal segmentation lie within the estimated bounds.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes MILAB;IAM Approved no  
  Call Number IAM @ iam @ LRM1995a Serial 1559  
Permanent link to this record
 
 
Author (up) Ole Larsen; Petia Radeva; Enric Marti edit  openurl
  Title Calculating the Bounds on the Optimal Parameters of Elasticity for a Snake Type Report
  Year 1994 Publication Technical Report Abbreviated Journal  
  Volume Issue Pages  
  Keywords  
  Abstract  
  Address Aalborg University  
  Corporate Author Thesis  
  Publisher Aalborg University, Laboratory of image Analysis. Place of Publication Denmark Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Aalborg University, Laboratory of image Analysis. Expedition Conference  
  Notes MILAB;IAM Approved no  
  Call Number IAM @ iam @ LRM1994 Serial 1560  
Permanent link to this record
 
 
Author (up) Ole Vilhelm-Larsen; Petia Radeva; Enric Marti edit   pdf
doi  openurl
  Title Guidelines for choosing optimal parameters of elasticity for snakes Type Book Chapter
  Year 1995 Publication Computer Analysis Of Images And Patterns Abbreviated Journal LNCS  
  Volume 970 Issue Pages 106-113  
  Keywords  
  Abstract This paper proposes a guidance in the process of choosing and using the parameters of elasticity of a snake in order to obtain a precise segmentation. A new two step procedure is defined based on upper and lower bounds on the parameters. Formulas, by which these bounds can be calculated for real images where parts of the contour may be missing, are presented. Experiments on segmentation of bone structures in X-ray images have verified the usefulness of the new procedure.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Lecture Notes in Computer Science Abbreviated Series Title LNCS  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes MILAB;IAM Approved no  
  Call Number IAM @ iam @ LRM1995b Serial 1558  
Permanent link to this record
 
 
Author (up) Oriol Pujol; Debora Gil; Petia Radeva edit   pdf
doi  openurl
  Title Fundamentals of Stop and Go active models Type Journal Article
  Year 2005 Publication Image and Vision Computing Abbreviated Journal  
  Volume 23 Issue 8 Pages 681-691  
  Keywords Deformable models; Geodesic snakes; Region-based segmentation  
  Abstract An efficient snake formulation should conform to the idea of picking the smoothest curve among all the shapes approximating an object of interest. In current geodesic snakes, the regularizing curvature also affects the convergence stage, hindering the latter at concave regions. In the present work, we make use of characteristic functions to define a novel geodesic formulation that decouples regularity and convergence. This term decoupling endows the snake with higher adaptability to non-convex shapes. Convergence is ensured by splitting the definition of the external force into an attractive vector field and a repulsive one. In our paper, we propose to use likelihood maps as approximation of characteristic functions of object appearance. The better efficiency and accuracy of our decoupled scheme are illustrated in the particular case of feature space-based segmentation.  
  Address  
  Corporate Author Thesis  
  Publisher Butterworth-Heinemann Place of Publication Newton, MA, USA Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0262-8856 ISBN Medium  
  Area Expedition Conference  
  Notes IAM;MILAB;HuPBA Approved no  
  Call Number IAM @ iam @ PGR2005 Serial 1629  
Permanent link to this record
 
 
Author (up) Oriol Ramos Terrades; Albert Berenguel; Debora Gil edit   pdf
url  openurl
  Title A flexible outlier detector based on a topology given by graph communities Type Miscellaneous
  Year 2020 Publication Arxiv Abbreviated Journal  
  Volume Issue Pages  
  Keywords  
  Abstract Outlier, or anomaly, detection is essential for optimal performance of machine learning methods and statistical predictive models. It is not just a technical step in a data cleaning process but a key topic in many fields such as fraudulent document detection, in medical applications and assisted diagnosis systems or detecting security threats. In contrast to population-based methods, neighborhood based local approaches are simple flexible methods that have the potential to perform well in small sample size unbalanced problems. However, a main concern of local approaches is the impact that the computation of each sample neighborhood has on the method performance. Most approaches use a distance in the feature space to define a single neighborhood that requires careful selection of several parameters. This work presents a local approach based on a local measure of the heterogeneity of sample labels in the feature space considered as a topological manifold. Topology is computed using the communities of a weighted graph codifying mutual nearest neighbors in the feature space. This way, we provide with a set of multiple neighborhoods able to describe the structure of complex spaces without parameter fine tuning. The extensive experiments on real-world data sets show that our approach overall outperforms, both, local and global strategies in multi and single view settings.  
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  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
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  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM; DAG; 600.139; 600.145; 600.140; 600.121 Approved no  
  Call Number Admin @ si @ RBG2020 Serial 3475  
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Author (up) Oriol Ramos Terrades; Albert Berenguel; Debora Gil edit   pdf
doi  openurl
  Title A Flexible Outlier Detector Based on a Topology Given by Graph Communities Type Journal Article
  Year 2022 Publication Big Data Research Abbreviated Journal BDR  
  Volume 29 Issue Pages 100332  
  Keywords Classification algorithms; Detection algorithms; Description of feature space local structure; Graph communities; Machine learning algorithms; Outlier detectors  
  Abstract Outlier detection is essential for optimal performance of machine learning methods and statistical predictive models. Their detection is especially determinant in small sample size unbalanced problems, since in such settings outliers become highly influential and significantly bias models. This particular experimental settings are usual in medical applications, like diagnosis of rare pathologies, outcome of experimental personalized treatments or pandemic emergencies. In contrast to population-based methods, neighborhood based local approaches compute an outlier score from the neighbors of each sample, are simple flexible methods that have the potential to perform well in small sample size unbalanced problems. A main concern of local approaches is the impact that the computation of each sample neighborhood has on the method performance. Most approaches use a distance in the feature space to define a single neighborhood that requires careful selection of several parameters, like the number of neighbors.
This work presents a local approach based on a local measure of the heterogeneity of sample labels in the feature space considered as a topological manifold. Topology is computed using the communities of a weighted graph codifying mutual nearest neighbors in the feature space. This way, we provide with a set of multiple neighborhoods able to describe the structure of complex spaces without parameter fine tuning. The extensive experiments on real-world and synthetic data sets show that our approach outperforms, both, local and global strategies in multi and single view settings.		  
  Address August 28, 2022  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes DAG; IAM; 600.140; 600.121; 600.139; 600.145; 600.159 Approved no  
  Call Number Admin @ si @ RBG2022a Serial 3718  
Permanent link to this record
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