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Author Mireia Sole; Joan Blanco; Debora Gil; Oliver Valero; Alvaro Pascual; B. Cardenas; G. Fonseka; E. Anton; Richard Frodsham; Francesca Vidal; Zaida Sarrate edit  url
openurl 
  Title Chromosomal positioning in spermatogenic cells is influenced by chromosomal factors associated with gene activity, bouquet formation, and meiotic sex-chromosome inactivation Type Journal Article
  Year 2021 Publication Chromosoma Abbreviated Journal (up)  
  Volume 130 Issue Pages 163-175  
  Keywords  
  Abstract Chromosome territoriality is not random along the cell cycle and it is mainly governed by intrinsic chromosome factors and gene expression patterns. Conversely, very few studies have explored the factors that determine chromosome territoriality and its influencing factors during meiosis. In this study, we analysed chromosome positioning in murine spermatogenic cells using three-dimensionally fluorescence in situ hybridization-based methodology, which allows the analysis of the entire karyotype. The main objective of the study was to decipher chromosome positioning in a radial axis (all analysed germ-cell nuclei) and longitudinal axis (only spermatozoa) and to identify the chromosomal factors that regulate such an arrangement. Results demonstrated that the radial positioning of chromosomes during spermatogenesis was cell-type specific and influenced by chromosomal factors associated to gene activity. Chromosomes with specific features that enhance transcription (high GC content, high gene density and high numbers of predicted expressed genes) were preferentially observed in the inner part of the nucleus in virtually all cell types. Moreover, the position of the sex chromosomes was influenced by their transcriptional status, from the periphery of the nucleus when its activity was repressed (pachytene) to a more internal position when it is partially activated (spermatid). At pachytene, chromosome positioning was also influenced by chromosome size due to the bouquet formation. Longitudinal chromosome positioning in the sperm nucleus was not random either, suggesting the importance of ordered longitudinal positioning for the release and activation of the paternal genome after fertilisation.  
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  Notes IAM; 600.145 Approved no  
  Call Number Admin @ si @ SBG2021 Serial 3592  
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Author Marta Ligero; Alonso Garcia Ruiz; Cristina Viaplana; Guillermo Villacampa; Maria V Raciti; Jaid Landa; Ignacio Matos; Juan Martin Liberal; Maria Ochoa de Olza; Cinta Hierro; Joaquin Mateo; Macarena Gonzalez; Rafael Morales Barrera; Cristina Suarez; Jordi Rodon; Elena Elez; Irene Braña; Eva Muñoz-Couselo; Ana Oaknin; Roberta Fasani; Paolo Nuciforo; Debora Gil; Carlota Rubio Perez; Joan Seoane; Enriqueta Felip; Manuel Escobar; Josep Tabernero; Joan Carles; Rodrigo Dienstmann; Elena Garralda; Raquel Perez Lopez edit  url
doi  openurl
  Title A CT-based radiomics signature is associated with response to immune checkpoint inhibitors in advanced solid tumors Type Journal Article
  Year 2021 Publication Radiology Abbreviated Journal (up)  
  Volume 299 Issue 1 Pages 109-119  
  Keywords  
  Abstract Background Reliable predictive imaging markers of response to immune checkpoint inhibitors are needed. Purpose To develop and validate a pretreatment CT-based radiomics signature to predict response to immune checkpoint inhibitors in advanced solid tumors. Materials and Methods In this retrospective study, a radiomics signature was developed in patients with advanced solid tumors (including breast, cervix, gastrointestinal) treated with anti-programmed cell death-1 or programmed cell death ligand-1 monotherapy from August 2012 to May 2018 (cohort 1). This was tested in patients with bladder and lung cancer (cohorts 2 and 3). Radiomics variables were extracted from all metastases delineated at pretreatment CT and selected by using an elastic-net model. A regression model combined radiomics and clinical variables with response as the end point. Biologic validation of the radiomics score with RNA profiling of cytotoxic cells (cohort 4) was assessed with Mann-Whitney analysis. Results The radiomics signature was developed in 85 patients (cohort 1: mean age, 58 years ± 13 [standard deviation]; 43 men) and tested on 46 patients (cohort 2: mean age, 70 years ± 12; 37 men) and 47 patients (cohort 3: mean age, 64 years ± 11; 40 men). Biologic validation was performed in a further cohort of 20 patients (cohort 4: mean age, 60 years ± 13; 14 men). The radiomics signature was associated with clinical response to immune checkpoint inhibitors (area under the curve [AUC], 0.70; 95% CI: 0.64, 0.77; P < .001). In cohorts 2 and 3, the AUC was 0.67 (95% CI: 0.58, 0.76) and 0.67 (95% CI: 0.56, 0.77; P < .001), respectively. A radiomics-clinical signature (including baseline albumin level and lymphocyte count) improved on radiomics-only performance (AUC, 0.74 [95% CI: 0.63, 0.84; P < .001]; Akaike information criterion, 107.00 and 109.90, respectively). Conclusion A pretreatment CT-based radiomics signature is associated with response to immune checkpoint inhibitors, likely reflecting the tumor immunophenotype. © RSNA, 2021 Online supplemental material is available for this article. See also the editorial by Summers in this issue.  
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  Notes IAM; 600.145 Approved no  
  Call Number Admin @ si @ LGV2021 Serial 3593  
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Author Debora Gil; Oriol Ramos Terrades; Raquel Perez edit  doi
openurl 
  Title Topological Radiomics (TOPiomics): Early Detection of Genetic Abnormalities in Cancer Treatment Evolution Type Book Chapter
  Year 2021 Publication Extended Abstracts GEOMVAP 2019, Trends in Mathematics 15 Abbreviated Journal (up)  
  Volume 15 Issue Pages 89–93  
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  Abstract Abnormalities in radiomic measures correlate to genomic alterations prone to alter the outcome of personalized anti-cancer treatments. TOPiomics is a new method for the early detection of variations in tumor imaging phenotype from a topological structure in multi-view radiomic spaces.  
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  Publisher Springer Nature Place of Publication Editor  
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  Notes IAM; DAG; 600.120; 600.145; 600.139 Approved no  
  Call Number Admin @ si @ GRP2021 Serial 3594  
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Author Jose Elias Yauri; Aura Hernandez-Sabate; Pau Folch; Debora Gil edit  doi
openurl 
  Title Mental Workload Detection Based on EEG Analysis Type Conference Article
  Year 2021 Publication Artificial Intelligent Research and Development. Proceedings 23rd International Conference of the Catalan Association for Artificial Intelligence. Abbreviated Journal (up)  
  Volume 339 Issue Pages 268-277  
  Keywords Cognitive states; Mental workload; EEG analysis; Neural Networks.  
  Abstract The study of mental workload becomes essential for human work efficiency, health conditions and to avoid accidents, since workload compromises both performance and awareness. Although workload has been widely studied using several physiological measures, minimising the sensor network as much as possible remains both a challenge and a requirement.
Electroencephalogram (EEG) signals have shown a high correlation to specific cognitive and mental states like workload. However, there is not enough evidence in the literature to validate how well models generalize in case of new subjects performing tasks of a workload similar to the ones included during model’s training.
In this paper we propose a binary neural network to classify EEG features across different mental workloads. Two workloads, low and medium, are induced using two variants of the N-Back Test. The proposed model was validated in a dataset collected from 16 subjects and shown a high level of generalization capability: model reported an average recall of 81.81% in a leave-one-out subject evaluation.
 
  Address Virtual; October 20-22 2021  
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  Area Expedition Conference CCIA  
  Notes IAM; 600.139; 600.118; 600.145 Approved no  
  Call Number Admin @ si @ Serial 3723  
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Author Guillermo Torres; Jan Rodríguez Dueñas; Sonia Baeza; Antoni Rosell; Carles Sanchez; Debora Gil edit   pdf
url  openurl
  Title Prediction of Malignancy in Lung Cancer using several strategies for the fusion of Multi-Channel Pyradiomics Images Type Conference Article
  Year 2023 Publication 7th Workshop on Digital Image Processing for Medical and Automotive Industry in the framework of SYNASC 2023 Abbreviated Journal (up)  
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  Abstract This study shows the generation process and the subsequent study of the representation space obtained by extracting GLCM texture features from computer-aided tomography (CT) scans of pulmonary nodules (PN). For this, data from 92 patients from the Germans Trias i Pujol University Hospital were used. The workflow focuses on feature extraction using Pyradiomics and the VGG16 Convolutional Neural Network (CNN). The aim of the study is to assess whether the data obtained have a positive impact on the diagnosis of lung cancer (LC). To design a machine learning (ML) model training method that allows generalization, we train SVM and neural network (NN) models, evaluating diagnosis performance using metrics defined at slice and nodule level.  
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  Area Expedition Conference DIPMAI  
  Notes IAM Approved no  
  Call Number Admin @ si @ TRB2023 Serial 3926  
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Author Guillermo Torres; Debora Gil; Antoni Rosell; S. Mena; Carles Sanchez edit  openurl
  Title Virtual Radiomics Biopsy for the Histological Diagnosis of Pulmonary Nodules Type Conference Article
  Year 2023 Publication 37th International Congress and Exhibition is organized by Computer Assisted Radiology and Surgery Abbreviated Journal (up)  
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  Address Munich; Germany; June 2023  
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  Area Expedition Conference CARS  
  Notes IAM Approved no  
  Call Number Admin @ si @ TGR2023a Serial 3950  
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Author Sonia Baeza; Debora Gil; Carles Sanchez; Guillermo Torres; Ignasi Garcia Olive; Ignasi Guasch; Samuel Garcia Reina; Felipe Andreo; Jose Luis Mate; Jose Luis Vercher; Antonio Rosell edit  openurl
  Title Biopsia virtual radiomica para el diagnóstico histológico de nódulos pulmonares – Resultados intermedios del proyecto Radiolung Type Conference Article
  Year 2023 Publication SEPAR Abbreviated Journal (up)  
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  Address Granada; Spain; June 2023  
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  Area Expedition Conference SEPAR  
  Notes IAM Approved no  
  Call Number Admin @ si @ BGS2023 Serial 3951  
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Author Debora Gil; Guillermo Torres; Carles Sanchez edit  openurl
  Title Transforming radiomic features into radiological words Type Conference Article
  Year 2023 Publication IEEE International Symposium on Biomedical Imaging Abbreviated Journal (up)  
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  Address Cartagena de Indias; Colombia; April 2023  
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  ISSN ISBN Medium  
  Area Expedition Conference ISBI  
  Notes IAM Approved no  
  Call Number Admin @ si @ GTS2023 Serial 3952  
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Author Pau Cano; Debora Gil; Eva Musulen edit  openurl
  Title Towards automatic detection of helicobacter pylori in histological samples of gastric tissue Type Conference Article
  Year 2023 Publication IEEE International Symposium on Biomedical Imaging Abbreviated Journal (up)  
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  Address Cartagena de Indias; Colombia; April 2023  
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  Area Expedition Conference ISBI  
  Notes IAM Approved no  
  Call Number Admin @ si @ CGM2023 Serial 3953  
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Author Guillermo Torres; Debora Gil; Antonio Rosell; Sonia Baeza; Carles Sanchez edit  openurl
  Title A radiomic biopsy for virtual histology of pulmonary nodules Type Conference Article
  Year 2023 Publication IEEE International Symposium on Biomedical Imaging Abbreviated Journal (up)  
  Volume Issue Pages  
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  Abstract Pòster  
  Address Cartagena de Indias; Colombia; April 2023  
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  ISSN ISBN Medium  
  Area Expedition Conference ISBI  
  Notes IAM Approved no  
  Call Number Admin @ si @ TGR2023b Serial 3954  
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