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Juan Borrego-Carazo; Carles Sanchez; David Castells; Jordi Carrabina; Debora Gil |
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A benchmark for the evaluation of computational methods for bronchoscopic navigation |
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2022 |
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International Journal of Computer Assisted Radiology and Surgery |
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Admin @ si @ BSC2022 |
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3832 |
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Antoni Rosell; Sonia Baeza; S. Garcia-Reina; JL. Mate; Ignasi Guasch; I. Nogueira; I. Garcia-Olive; Guillermo Torres; Carles Sanchez; Debora Gil |
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EP01.05-001 Radiomics to Increase the Effectiveness of Lung Cancer Screening Programs. Radiolung Preliminary Results |
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2022 |
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Journal of Thoracic Oncology |
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JTO |
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17 |
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9 |
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S182 |
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Admin @ si @ RBG2022b |
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3834 |
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Antoni Rosell; Sonia Baeza; S. Garcia-Reina; JL. Mate; Ignasi Guasch; I. Nogueira; I. Garcia-Olive; Guillermo Torres; Carles Sanchez; Debora Gil |
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Radiomics to increase the effectiveness of lung cancer screening programs. Radiolung preliminary results. |
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2022 |
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European Respiratory Journal |
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ERJ |
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60 |
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66 |
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Admin @ si @ RBG2022c |
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3835 |
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Sonia Baeza; R.Domingo; M.Salcedo; G.Moragas; J.Deportos; I.Garcia Olive; Carles Sanchez; Debora Gil; Antoni Rosell |
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Artificial Intelligence to Optimize Pulmonary Embolism Diagnosis During Covid-19 Pandemic by Perfusion SPECT/CT, a Pilot Study |
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2021 |
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American Journal of Respiratory and Critical Care Medicine |
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IAM; 600.145 |
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Admin @ si @ BDS2021 |
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3591 |
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Mireia Sole; Joan Blanco; Debora Gil; Oliver Valero; Alvaro Pascual; B. Cardenas; G. Fonseka; E. Anton; Richard Frodsham; Francesca Vidal; Zaida Sarrate |
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Chromosomal positioning in spermatogenic cells is influenced by chromosomal factors associated with gene activity, bouquet formation, and meiotic sex-chromosome inactivation |
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2021 |
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Chromosoma |
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130 |
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163-175 |
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Chromosome territoriality is not random along the cell cycle and it is mainly governed by intrinsic chromosome factors and gene expression patterns. Conversely, very few studies have explored the factors that determine chromosome territoriality and its influencing factors during meiosis. In this study, we analysed chromosome positioning in murine spermatogenic cells using three-dimensionally fluorescence in situ hybridization-based methodology, which allows the analysis of the entire karyotype. The main objective of the study was to decipher chromosome positioning in a radial axis (all analysed germ-cell nuclei) and longitudinal axis (only spermatozoa) and to identify the chromosomal factors that regulate such an arrangement. Results demonstrated that the radial positioning of chromosomes during spermatogenesis was cell-type specific and influenced by chromosomal factors associated to gene activity. Chromosomes with specific features that enhance transcription (high GC content, high gene density and high numbers of predicted expressed genes) were preferentially observed in the inner part of the nucleus in virtually all cell types. Moreover, the position of the sex chromosomes was influenced by their transcriptional status, from the periphery of the nucleus when its activity was repressed (pachytene) to a more internal position when it is partially activated (spermatid). At pachytene, chromosome positioning was also influenced by chromosome size due to the bouquet formation. Longitudinal chromosome positioning in the sperm nucleus was not random either, suggesting the importance of ordered longitudinal positioning for the release and activation of the paternal genome after fertilisation. |
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IAM; 600.145 |
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Admin @ si @ SBG2021 |
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3592 |
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Marta Ligero; Alonso Garcia Ruiz; Cristina Viaplana; Guillermo Villacampa; Maria V Raciti; Jaid Landa; Ignacio Matos; Juan Martin Liberal; Maria Ochoa de Olza; Cinta Hierro; Joaquin Mateo; Macarena Gonzalez; Rafael Morales Barrera; Cristina Suarez; Jordi Rodon; Elena Elez; Irene Braña; Eva Muñoz-Couselo; Ana Oaknin; Roberta Fasani; Paolo Nuciforo; Debora Gil; Carlota Rubio Perez; Joan Seoane; Enriqueta Felip; Manuel Escobar; Josep Tabernero; Joan Carles; Rodrigo Dienstmann; Elena Garralda; Raquel Perez Lopez |
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A CT-based radiomics signature is associated with response to immune checkpoint inhibitors in advanced solid tumors |
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Journal Article |
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Year |
2021 |
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Radiology |
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299 |
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1 |
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109-119 |
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Background Reliable predictive imaging markers of response to immune checkpoint inhibitors are needed. Purpose To develop and validate a pretreatment CT-based radiomics signature to predict response to immune checkpoint inhibitors in advanced solid tumors. Materials and Methods In this retrospective study, a radiomics signature was developed in patients with advanced solid tumors (including breast, cervix, gastrointestinal) treated with anti-programmed cell death-1 or programmed cell death ligand-1 monotherapy from August 2012 to May 2018 (cohort 1). This was tested in patients with bladder and lung cancer (cohorts 2 and 3). Radiomics variables were extracted from all metastases delineated at pretreatment CT and selected by using an elastic-net model. A regression model combined radiomics and clinical variables with response as the end point. Biologic validation of the radiomics score with RNA profiling of cytotoxic cells (cohort 4) was assessed with Mann-Whitney analysis. Results The radiomics signature was developed in 85 patients (cohort 1: mean age, 58 years ± 13 [standard deviation]; 43 men) and tested on 46 patients (cohort 2: mean age, 70 years ± 12; 37 men) and 47 patients (cohort 3: mean age, 64 years ± 11; 40 men). Biologic validation was performed in a further cohort of 20 patients (cohort 4: mean age, 60 years ± 13; 14 men). The radiomics signature was associated with clinical response to immune checkpoint inhibitors (area under the curve [AUC], 0.70; 95% CI: 0.64, 0.77; P < .001). In cohorts 2 and 3, the AUC was 0.67 (95% CI: 0.58, 0.76) and 0.67 (95% CI: 0.56, 0.77; P < .001), respectively. A radiomics-clinical signature (including baseline albumin level and lymphocyte count) improved on radiomics-only performance (AUC, 0.74 [95% CI: 0.63, 0.84; P < .001]; Akaike information criterion, 107.00 and 109.90, respectively). Conclusion A pretreatment CT-based radiomics signature is associated with response to immune checkpoint inhibitors, likely reflecting the tumor immunophenotype. © RSNA, 2021 Online supplemental material is available for this article. See also the editorial by Summers in this issue. |
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IAM; 600.145 |
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Admin @ si @ LGV2021 |
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3593 |
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Debora Gil; Antonio Esteban Lansaque; Agnes Borras; Esmitt Ramirez; Carles Sanchez |
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Intraoperative Extraction of Airways Anatomy in VideoBronchoscopy |
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2020 |
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IEEE Access |
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ACCESS |
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8 |
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159696 - 159704 |
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A main bottleneck in bronchoscopic biopsy sampling is to efficiently reach the lesion navigating across bronchial levels. Any guidance system should be able to localize the scope position during the intervention with minimal costs and alteration of clinical protocols. With the final goal of an affordable image-based guidance, this work presents a novel strategy to extract and codify the anatomical structure of bronchi, as well as, the scope navigation path from videobronchoscopy. Experiments using interventional data show that our method accurately identifies the bronchial structure. Meanwhile, experiments using simulated data verify that the extracted navigation path matches the 3D route. |
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IAM; 600.139; 600.145 |
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Admin @ si @ GEB2020 |
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3467 |
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Guillermo Torres; Debora Gil |
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A multi-shape loss function with adaptive class balancing for the segmentation of lung structures |
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2020 |
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International Journal of Computer Assisted Radiology and Surgery |
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IJCAR |
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15 |
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1 |
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S154-55 |
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Admin @ si @ ToG2020 |
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3590 |
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Debora Gil; Ruth Aris; Agnes Borras; Esmitt Ramirez; Rafael Sebastian; Mariano Vazquez |
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Influence of fiber connectivity in simulations of cardiac biomechanics |
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2019 |
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International Journal of Computer Assisted Radiology and Surgery |
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IJCAR |
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14 |
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63–72 |
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Cardiac electromechanical simulations; Diffusion tensor imaging; Fiber connectivity |
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PURPOSE:
Personalized computational simulations of the heart could open up new improved approaches to diagnosis and surgery assistance systems. While it is fully recognized that myocardial fiber orientation is central for the construction of realistic computational models of cardiac electromechanics, the role of its overall architecture and connectivity remains unclear. Morphological studies show that the distribution of cardiac muscular fibers at the basal ring connects epicardium and endocardium. However, computational models simplify their distribution and disregard the basal loop. This work explores the influence in computational simulations of fiber distribution at different short-axis cuts.
METHODS:
We have used a highly parallelized computational solver to test different fiber models of ventricular muscular connectivity. We have considered two rule-based mathematical models and an own-designed method preserving basal connectivity as observed in experimental data. Simulated cardiac functional scores (rotation, torsion and longitudinal shortening) were compared to experimental healthy ranges using generalized models (rotation) and Mahalanobis distances (shortening, torsion).
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The probability of rotation was significantly lower for ruled-based models [95% CI (0.13, 0.20)] in comparison with experimental data [95% CI (0.23, 0.31)]. The Mahalanobis distance for experimental data was in the edge of the region enclosing 99% of the healthy population.
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Cardiac electromechanical simulations of the heart with fibers extracted from experimental data produce functional scores closer to healthy ranges than rule-based models disregarding architecture connectivity. |
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IAM; 600.096; 601.323; 600.139; 600.145 |
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Admin @ si @ GAB2019a |
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3133 |
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Marta Diez-Ferrer; Arturo Morales; Rosa Lopez Lisbona; Noelia Cubero; Cristian Tebe; Susana Padrones; Samantha Aso; Jordi Dorca; Debora Gil; Antoni Rosell |
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Ultrathin Bronchoscopy with and without Virtual Bronchoscopic Navigation: Influence of Segmentation on Diagnostic Yield |
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2019 |
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Respiration |
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RES |
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97 |
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3 |
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252-258 |
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Lung cancer; Peripheral lung lesion; Diagnosis; Bronchoscopy; Ultrathin bronchoscopy; Virtual bronchoscopic navigation |
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Background: Bronchoscopy is a safe technique for diagnosing peripheral pulmonary lesions (PPLs), and virtual bronchoscopic navigation (VBN) helps guide the bronchoscope to PPLs. Objectives: We aimed to compare the diagnostic yield of VBN-guided and unguided ultrathin bronchoscopy (UTB) and explore clinical and technical factors associated with better results. We developed a diagnostic algorithm for deciding whether to use VBN to reach PPLs or choose an alternative diagnostic approach. Methods: We compared diagnostic yield between VBN-UTB (prospective cases) and unguided UTB (historical controls) and analyzed the VBN-UTB subgroup to identify clinical and technical variables that could predict the success of VBN-UTB. Results: Fifty-five cases and 110 controls were included. The overall diagnostic yield did not differ between the VBN-guided and unguided arms (47 and 40%, respectively; p = 0.354). Although the yield was slightly higher for PPLs ≤20 mm in the VBN-UTB arm, the difference was not significant (p = 0.069). No other clinical characteristics were associated with a higher yield in a subgroup analysis, but an 85% diagnostic yield was observed when segmentation was optimal and the PPL was endobronchial (vs. 30% when segmentation was suboptimal and 20% when segmentation was optimal but the PPL was extrabronchial). Conclusions: VBN-guided UTB is not superior to unguided UTB. A greater impact of VBN-guided over unguided UTB is highly dependent on both segmentation quality and an endobronchial location of the PPL. Segmentation quality should be considered before starting a procedure, when an alternative technique that may improve yield can be chosen, saving time and resources. |
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IAM; 600.145; 600.139 |
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Admin @ si @ DML2019 |
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3134 |
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