David Roche, Debora Gil, & Jesus Giraldo. (2014). Mathematical modeling of G protein-coupled receptor function: What can we learn from empirical and mechanistic models? In G Protein-Coupled Receptors – Modeling and Simulation Advances in Experimental Medicine and Biology (Vol. 796, pp. 159–181). Springer Netherlands.
Abstract: Empirical and mechanistic models differ in their approaches to the analysis of pharmacological effect. Whereas the parameters of the former are not physical constants those of the latter embody the nature, often complex, of biology. Empirical models are exclusively used for curve fitting, merely to characterize the shape of the E/[A] curves. Mechanistic models, on the contrary, enable the examination of mechanistic hypotheses by parameter simulation. Regretfully, the many parameters that mechanistic models may include can represent a great difficulty for curve fitting, representing, thus, a challenge for computational method development. In the present study some empirical and mechanistic models are shown and the connections, which may appear in a number of cases between them, are analyzed from the curves they yield. It may be concluded that systematic and careful curve shape analysis can be extremely useful for the understanding of receptor function, ligand classification and drug discovery, thus providing a common language for the communication between pharmacologists and medicinal chemists.
Keywords: β-arrestin; biased agonism; curve fitting; empirical modeling; evolutionary algorithm; functional selectivity; G protein; GPCR; Hill coefficient; intrinsic efficacy; inverse agonism; mathematical modeling; mechanistic modeling; operational model; parameter optimization; receptor dimer; receptor oligomerization; receptor constitutive activity; signal transduction; two-state model
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Javier Marin, David Vazquez, Antonio Lopez, Jaume Amores, & Ludmila I. Kuncheva. (2014). Occlusion handling via random subspace classifiers for human detection. TSMCB - IEEE Transactions on Systems, Man, and Cybernetics (Part B), 44(3), 342–354.
Abstract: This paper describes a general method to address partial occlusions for human detection in still images. The Random Subspace Method (RSM) is chosen for building a classifier ensemble robust against partial occlusions. The component classifiers are chosen on the basis of their individual and combined performance. The main contribution of this work lies in our approach’s capability to improve the detection rate when partial occlusions are present without compromising the detection performance on non occluded data. In contrast to many recent approaches, we propose a method which does not require manual labelling of body parts, defining any semantic spatial components, or using additional data coming from motion or stereo. Moreover, the method can be easily extended to other object classes. The experiments are performed on three large datasets: the INRIA person dataset, the Daimler Multicue dataset, and a new challenging dataset, called PobleSec, in which a considerable number of targets are partially occluded. The different approaches are evaluated at the classification and detection levels for both partially occluded and non-occluded data. The experimental results show that our detector outperforms state-of-the-art approaches in the presence of partial occlusions, while offering performance and reliability similar to those of the holistic approach on non-occluded data. The datasets used in our experiments have been made publicly available for benchmarking purposes
Keywords: Pedestriand Detection; occlusion handling
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Thierry Brouard, Jordi Gonzalez, Caifeng Shan, Massimo Piccardi, & Larry S. Davis. (2014). Special issue on background modeling for foreground detection in real-world dynamic scenes. MVAP - Machine Vision and Applications, 25(5), 1101–1103.
Abstract: Although background modeling and foreground detection are not mandatory steps for computer vision applications, they may prove useful as they separate the primal objects usually called “foreground” from the remaining part of the scene called “background”, and permits different algorithmic treatment in the video processing field such as video surveillance, optical motion capture, multimedia applications, teleconferencing and human–computer interfaces. Conventional background modeling methods exploit the temporal variation of each pixel to model the background, and the foreground detection is made using change detection. The last decade witnessed very significant publications on background modeling but recently new applications in which background is not static, such as recordings taken from mobile devices or Internet videos, need new developments to detect robustly moving objects in challenging environments. Thus, effective methods for robustness to deal both with dynamic backgrounds, i
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A. Ruiz, Joost Van de Weijer, & Xavier Binefa. (2014). Regularized Multi-Concept MIL for weakly-supervised facial behavior categorization. In 25th British Machine Vision Conference.
Abstract: We address the problem of estimating high-level semantic labels for videos of recorded people by means of analysing their facial expressions. This problem, to which we refer as facial behavior categorization, is a weakly-supervised learning problem where we do not have access to frame-by-frame facial gesture annotations but only weak-labels at the video level are available. Therefore, the goal is to learn a set of discriminative expressions and how they determine the video weak-labels. Facial behavior categorization can be posed as a Multi-Instance-Learning (MIL) problem and we propose a novel MIL method called Regularized Multi-Concept MIL to solve it. In contrast to previous approaches applied in facial behavior analysis, RMC-MIL follows a Multi-Concept assumption which allows different facial expressions (concepts) to contribute differently to the video-label. Moreover, to handle with the high-dimensional nature of facial-descriptors, RMC-MIL uses a discriminative approach to model the concepts and structured sparsity regularization to discard non-informative features. RMC-MIL is posed as a convex-constrained optimization problem where all the parameters are jointly learned using the Projected-Quasi-Newton method. In our experiments, we use two public data-sets to show the advantages of the Regularized Multi-Concept approach and its improvement compared to existing MIL methods. RMC-MIL outperforms state-of-the-art results in the UNBC data-set for pain detection.
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T.Chauhan, E.Perales, Kaida Xiao, E.Hird, Dimosthenis Karatzas, & Sophie Wuerger. (2014). The achromatic locus: Effect of navigation direction in color space. VSS - Journal of Vision, 14 (1)(25), 1–11.
Abstract: 5Y Impact Factor: 2.99 / 1st (Ophthalmology)
An achromatic stimulus is defined as a patch of light that is devoid of any hue. This is usually achieved by asking observers to adjust the stimulus such that it looks neither red nor green and at the same time neither yellow nor blue. Despite the theoretical and practical importance of the achromatic locus, little is known about the variability in these settings. The main purpose of the current study was to evaluate whether achromatic settings were dependent on the task of the observers, namely the navigation direction in color space. Observers could either adjust the test patch along the two chromatic axes in the CIE u*v* diagram or, alternatively, navigate along the unique-hue lines. Our main result is that the navigation method affects the reliability of these achromatic settings. Observers are able to make more reliable achromatic settings when adjusting the test patch along the directions defined by the four unique hues as opposed to navigating along the main axes in the commonly used CIE u*v* chromaticity plane. This result holds across different ambient viewing conditions (Dark, Daylight, Cool White Fluorescent) and different test luminance levels (5, 20, and 50 cd/m2). The reduced variability in the achromatic settings is consistent with the idea that internal color representations are more aligned with the unique-hue lines than the u* and v* axes.
Keywords: achromatic; unique hues; color constancy; luminance; color space
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Antonio Clavelli, Dimosthenis Karatzas, Josep Llados, Mario Ferraro, & Giuseppe Boccignone. (2014). Modelling task-dependent eye guidance to objects in pictures. CoCom - Cognitive Computation, 6(3), 558–584.
Abstract: 5Y Impact Factor: 1.14 / 3rd (Computer Science, Artificial Intelligence)
We introduce a model of attentional eye guidance based on the rationale that the deployment of gaze is to be considered in the context of a general action-perception loop relying on two strictly intertwined processes: sensory processing, depending on current gaze position, identifies sources of information that are most valuable under the given task; motor processing links such information with the oculomotor act by sampling the next gaze position and thus performing the gaze shift. In such a framework, the choice of where to look next is task-dependent and oriented to classes of objects embedded within pictures of complex scenes. The dependence on task is taken into account by exploiting the value and the payoff of gazing at certain image patches or proto-objects that provide a sparse representation of the scene objects. The different levels of the action-perception loop are represented in probabilistic form and eventually give rise to a stochastic process that generates the gaze sequence. This way the model also accounts for statistical properties of gaze shifts such as individual scan path variability. Results of the simulations are compared either with experimental data derived from publicly available datasets and from our own experiments.
Keywords: Visual attention; Gaze guidance; Value; Payoff; Stochastic fixation prediction
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A.Kesidis, & Dimosthenis Karatzas. (2014). Logo and Trademark Recognition. In D. Doermann, & K. Tombre (Eds.), Handbook of Document Image Processing and Recognition (Vol. D, pp. 591–646). Springer London.
Abstract: The importance of logos and trademarks in nowadays society is indisputable, variably seen under a positive light as a valuable service for consumers or a negative one as a catalyst of ever-increasing consumerism. This chapter discusses the technical approaches for enabling machines to work with logos, looking into the latest methodologies for logo detection, localization, representation, recognition, retrieval, and spotting in a variety of media. This analysis is presented in the context of three different applications covering the complete depth and breadth of state of the art techniques. These are trademark retrieval systems, logo recognition in document images, and logo detection and removal in images and videos. This chapter, due to the very nature of logos and trademarks, brings together various facets of document image analysis spanning graphical and textual content, while it links document image analysis to other computer vision domains, especially when it comes to the analysis of real-scene videos and images.
Keywords: Logo recognition; Logo removal; Logo spotting; Trademark registration; Trademark retrieval systems
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Patricia Marquez, Debora Gil, R.Mester, & Aura Hernandez-Sabate. (2014). Local Analysis of Confidence Measures for Optical Flow Quality Evaluation. In 9th International Conference on Computer Vision Theory and Applications (Vol. 3, pp. 450–457).
Abstract: Optical Flow (OF) techniques facing the complexity of real sequences have been developed in the last years. Even using the most appropriate technique for our specific problem, at some points the output flow might fail to achieve the minimum error required for the system. Confidence measures computed from either input data or OF output should discard those points where OF is not accurate enough for its further use. It follows that evaluating the capabilities of a confidence measure for bounding OF error is as important as the definition
itself. In this paper we analyze different confidence measures and point out their advantages and limitations for their use in real world settings. We also explore the agreement with current tools for their evaluation of confidence measures performance.
Keywords: Optical Flow; Confidence Measure; Performance Evaluation.
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Jiaolong Xu, David Vazquez, Antonio Lopez, Javier Marin, & Daniel Ponsa. (2014). Learning a Part-based Pedestrian Detector in Virtual World. TITS - IEEE Transactions on Intelligent Transportation Systems, 15(5), 2121–2131.
Abstract: Detecting pedestrians with on-board vision systems is of paramount interest for assisting drivers to prevent vehicle-to-pedestrian accidents. The core of a pedestrian detector is its classification module, which aims at deciding if a given image window contains a pedestrian. Given the difficulty of this task, many classifiers have been proposed during the last fifteen years. Among them, the so-called (deformable) part-based classifiers including multi-view modeling are usually top ranked in accuracy. Training such classifiers is not trivial since a proper aspect clustering and spatial part alignment of the pedestrian training samples are crucial for obtaining an accurate classifier. In this paper, first we perform automatic aspect clustering and part alignment by using virtual-world pedestrians, i.e., human annotations are not required. Second, we use a mixture-of-parts approach that allows part sharing among different aspects. Third, these proposals are integrated in a learning framework which also allows to incorporate real-world training data to perform domain adaptation between virtual- and real-world cameras. Overall, the obtained results on four popular on-board datasets show that our proposal clearly outperforms the state-of-the-art deformable part-based detector known as latent SVM.
Keywords: Domain Adaptation; Pedestrian Detection; Virtual Worlds
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Jiaolong Xu, Sebastian Ramos, David Vazquez, & Antonio Lopez. (2014). Cost-sensitive Structured SVM for Multi-category Domain Adaptation. In 22nd International Conference on Pattern Recognition (pp. 3886–3891). IEEE.
Abstract: Domain adaptation addresses the problem of accuracy drop that a classifier may suffer when the training data (source domain) and the testing data (target domain) are drawn from different distributions. In this work, we focus on domain adaptation for structured SVM (SSVM). We propose a cost-sensitive domain adaptation method for SSVM, namely COSS-SSVM. In particular, during the re-training of an adapted classifier based on target and source data, the idea that we explore consists in introducing a non-zero cost even for correctly classified source domain samples. Eventually, we aim to learn a more targetoriented classifier by not rewarding (zero loss) properly classified source-domain training samples. We assess the effectiveness of COSS-SSVM on multi-category object recognition.
Keywords: Domain Adaptation; Pedestrian Detection
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Onur Ferhat, Fernando Vilariño, & F. Javier Sanchez. (2014). A cheap portable eye-tracker solution for common setups. JEMR - Journal of Eye Movement Research, 7(3), 1–10.
Abstract: We analyze the feasibility of a cheap eye-tracker where the hardware consists of a single webcam and a Raspberry Pi device. Our aim is to discover the limits of such a system and to see whether it provides an acceptable performance. We base our work on the open source Opengazer (Zielinski, 2013) and we propose several improvements to create a robust, real-time system which can work on a computer with 30Hz sampling rate. After assessing the accuracy of our eye-tracker in elaborated experiments involving 12 subjects under 4 different system setups, we install it on a Raspberry Pi to create a portable stand-alone eye-tracker which achieves 1.42° horizontal accuracy with 3Hz refresh rate for a building cost of 70 Euros.
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Oscar Lopes, Miguel Reyes, Sergio Escalera, & Jordi Gonzalez. (2014). Spherical Blurred Shape Model for 3-D Object and Pose Recognition: Quantitative Analysis and HCI Applications in Smart Environments. TSMCB - IEEE Transactions on Systems, Man and Cybernetics (Part B), 44(12), 2379–2390.
Abstract: The use of depth maps is of increasing interest after the advent of cheap multisensor devices based on structured light, such as Kinect. In this context, there is a strong need of powerful 3-D shape descriptors able to generate rich object representations. Although several 3-D descriptors have been already proposed in the literature, the research of discriminative and computationally efficient descriptors is still an open issue. In this paper, we propose a novel point cloud descriptor called spherical blurred shape model (SBSM) that successfully encodes the structure density and local variabilities of an object based on shape voxel distances and a neighborhood propagation strategy. The proposed SBSM is proven to be rotation and scale invariant, robust to noise and occlusions, highly discriminative for multiple categories of complex objects like the human hand, and computationally efficient since the SBSM complexity is linear to the number of object voxels. Experimental evaluation in public depth multiclass object data, 3-D facial expressions data, and a novel hand poses data sets show significant performance improvements in relation to state-of-the-art approaches. Moreover, the effectiveness of the proposal is also proved for object spotting in 3-D scenes and for real-time automatic hand pose recognition in human computer interaction scenarios.
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Xavier Perez Sala, Sergio Escalera, Cecilio Angulo, & Jordi Gonzalez. (2014). A survey on model based approaches for 2D and 3D visual human pose recovery. SENS - Sensors, 14(3), 4189–4210.
Abstract: Human Pose Recovery has been studied in the field of Computer Vision for the last 40 years. Several approaches have been reported, and significant improvements have been obtained in both data representation and model design. However, the problem of Human Pose Recovery in uncontrolled environments is far from being solved. In this paper, we define a general taxonomy to group model based approaches for Human Pose Recovery, which is composed of five main modules: appearance, viewpoint, spatial relations, temporal consistence, and behavior. Subsequently, a methodological comparison is performed following the proposed taxonomy, evaluating current SoA approaches in the aforementioned five group categories. As a result of this comparison, we discuss the main advantages and drawbacks of the reviewed literature.
Keywords: human pose recovery; human body modelling; behavior analysis; computer vision
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Frederic Sampedro, Anna Domenech, & Sergio Escalera. (2014). Obtaining quantitative global tumoral state indicators based on whole-body PET/CT scans: A breast cancer case study. NMC - Nuclear Medicine Communications, 35(4), 362–371.
Abstract: Objectives: In this work we address the need for the computation of quantitative global tumoral state indicators from oncological whole-body PET/computed tomography scans. The combination of such indicators with other oncological information such as tumor markers or biopsy results would prove useful in oncological decision-making scenarios.
Materials and methods: From an ordering of 100 breast cancer patients on the basis of oncological state through visual analysis by a consensus of nuclear medicine specialists, a set of numerical indicators computed from image analysis of the PET/computed tomography scan is presented, which attempts to summarize a patient’s oncological state in a quantitative manner taking into consideration the total tumor volume, aggressiveness, and spread.
Results: Results obtained by comparative analysis of the proposed indicators with respect to the experts’ evaluation show up to 87% Pearson’s correlation coefficient when providing expert-guided PET metabolic tumor volume segmentation and 64% correlation when using completely automatic image analysis techniques.
Conclusion: Global quantitative tumor information obtained by whole-body PET/CT image analysis can prove useful in clinical nuclear medicine settings and oncological decision-making scenarios. The completely automatic computation of such indicators would improve its impact as time efficiency and specialist independence would be achieved.
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Mohammad Ali Bagheri, Qigang Gao, & Sergio Escalera. (2014). Generic Subclass Ensemble: A Novel Approach to Ensemble Classification. In 22nd International Conference on Pattern Recognition (pp. 1254–1259).
Abstract: Multiple classifier systems, also known as classifier ensembles, have received great attention in recent years because of their improved classification accuracy in different applications. In this paper, we propose a new general approach to ensemble classification, named generic subclass ensemble, in which each base classifier is trained with data belonging to a subset of classes, and thus discriminates among a subset of target categories. The ensemble classifiers are then fused using a combination rule. The proposed approach differs from existing methods that manipulate the target attribute, since in our approach individual classification problems are not restricted to two-class problems. We perform a series of experiments to evaluate the efficiency of the generic subclass approach on a set of benchmark datasets. Experimental results with multilayer perceptrons show that the proposed approach presents a viable alternative to the most commonly used ensemble classification approaches.
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