Abstract: People suffering Bipolar Disorder (BD) experiment changes in mood status having depressive or manic episodes with normal periods in the middle. BD is a chronic disease with a high level of non-adherence to medication that needs a continuous monitoring of patients to detect when they relapse in an episode, so that physicians can take care of them. Here we present MoodRecord, an easy-to-use, non-intrusive, multilingual, robust and scalable platform suitable for home monitoring patients with BD, that allows physicians and relatives to track the patient state and get alarms when abnormalities occur.
MoodRecord takes advantage of the capabilities of smartphones as a communication and recording device to do a continuous monitoring of patients. It automatically records user activity, and asks the user to answer some questions or to record himself in video, according to a predefined plan designed by physicians. The video is analysed, recognising the mood status from images and bipolar assessment scores are extracted from speech parameters. The data obtained from the different sources are merged periodically to observe if a relapse may start and if so, raise the corresponding alarm. The application got a positive evaluation in a pilot with users from three different countries. During the pilot, the predictions of the voice and image modules showed a coherent correlation with the diagnosis performed by clinicians.

Abstract: Background Reliable predictive imaging markers of response to immune checkpoint inhibitors are needed. Purpose To develop and validate a pretreatment CT-based radiomics signature to predict response to immune checkpoint inhibitors in advanced solid tumors. Materials and Methods In this retrospective study, a radiomics signature was developed in patients with advanced solid tumors (including breast, cervix, gastrointestinal) treated with anti-programmed cell death-1 or programmed cell death ligand-1 monotherapy from August 2012 to May 2018 (cohort 1). This was tested in patients with bladder and lung cancer (cohorts 2 and 3). Radiomics variables were extracted from all metastases delineated at pretreatment CT and selected by using an elastic-net model. A regression model combined radiomics and clinical variables with response as the end point. Biologic validation of the radiomics score with RNA profiling of cytotoxic cells (cohort 4) was assessed with Mann-Whitney analysis. Results The radiomics signature was developed in 85 patients (cohort 1: mean age, 58 years ± 13 [standard deviation]; 43 men) and tested on 46 patients (cohort 2: mean age, 70 years ± 12; 37 men) and 47 patients (cohort 3: mean age, 64 years ± 11; 40 men). Biologic validation was performed in a further cohort of 20 patients (cohort 4: mean age, 60 years ± 13; 14 men). The radiomics signature was associated with clinical response to immune checkpoint inhibitors (area under the curve [AUC], 0.70; 95% CI: 0.64, 0.77; P < .001). In cohorts 2 and 3, the AUC was 0.67 (95% CI: 0.58, 0.76) and 0.67 (95% CI: 0.56, 0.77; P < .001), respectively. A radiomics-clinical signature (including baseline albumin level and lymphocyte count) improved on radiomics-only performance (AUC, 0.74 [95% CI: 0.63, 0.84; P < .001]; Akaike information criterion, 107.00 and 109.90, respectively). Conclusion A pretreatment CT-based radiomics signature is associated with response to immune checkpoint inhibitors, likely reflecting the tumor immunophenotype. © RSNA, 2021 Online supplemental material is available for this article. See also the editorial by Summers in this issue.

Abstract: Background and objective:An accurate segmentation of lung nodules in computed tomography images is a crucial step for the physical characterization of the tumour. Being often completely manually accomplished, nodule segmentation turns to be a tedious and time-consuming procedure and this represents a high obstacle in clinical practice. In this paper, we propose a novel Convolutional Neural Network for nodule segmentation that combines a light and efficient architecture with innovative loss function and segmentation strategy. Methods:In contrast to most of the standard end-to-end architectures for nodule segmentation, our network learns the context of the nodules by producing two masks representing all the background and secondary-important elements in the Computed Tomography scan. The nodule is detected by subtracting the context from the original scan image. Additionally, we introduce an asymmetric loss function that automatically compensates for potential errors in the nodule annotations. We trained and tested our Neural Network on the public LIDC-IDRI database, compared it with the state of the art and run a pseudo-Turing test between four radiologists and the network. Results:The results proved that the behaviour of the algorithm is very near to the human performance and its segmentation masks are almost indistinguishable from the ones made by the radiologists. Our method clearly outperforms the state of the art on CT nodule segmentation in terms of F1 score and IoU of and respectively. Conclusions: The main structure of the network ensures all the properties of the UNet architecture, while the Multi Convolutional Layers give a more accurate pattern recognition. The newly adopted solutions also increase the details on the border of the nodule, even under the noisiest conditions. This method can be applied now for single CT slice nodule segmentation and it represents a starting point for the future development of a fully automatic 3D segmentation software.

Abstract: The determination of precise skin lesion boundaries in dermoscopic images using automated methods faces many challenges, most importantly, the presence of hair, inconspicuous lesion edges and low contrast in dermoscopic images, and variability in the color, texture and shapes of skin lesions. Existing deep learning-based skin lesion segmentation algorithms are expensive in terms of computational time and memory. Consequently, running such segmentation algorithms requires a powerful GPU and high bandwidth memory, which are not available in dermoscopy devices. Thus, this article aims to achieve precise skin lesion segmentation with minimum resources: a lightweight, efficient generative adversarial network (GAN) model called SLSNet, which combines 1-D kernel factorized networks, position and channel attention, and multiscale aggregation mechanisms with a GAN model. The 1-D kernel factorized network reduces the computational cost of 2D filtering. The position and channel attention modules enhance the discriminative ability between the lesion and non-lesion feature representations in spatial and channel dimensions, respectively. A multiscale block is also used to aggregate the coarse-to-fine features of input skin images and reduce the effect of the artifacts. SLSNet is evaluated on two publicly available datasets: ISBI 2017 and the ISIC 2018. Although SLSNet has only 2.35 million parameters, the experimental results demonstrate that it achieves segmentation results on a par with the state-of-the-art skin lesion segmentation methods with an accuracy of 97.61%, and Dice and Jaccard similarity coefficients of 90.63% and 81.98%, respectively. SLSNet can run at more than 110 frames per second (FPS) in a single GTX1080Ti GPU, which is faster than well-known deep learning-based image segmentation models, such as FCN. Therefore, SLSNet can be used for practical dermoscopic applications.

Abstract: Sign language, as a different form of the communication language, is important to large groups of people in society. There are different signs in each sign language with variability in hand shape, motion profile, and position of the hand, face, and body parts contributing to each sign. So, visual sign language recognition is a complex research area in computer vision. Many models have been proposed by different researchers with significant improvement by deep learning approaches in recent years. In this survey, we review the vision-based proposed models of sign language recognition using deep learning approaches from the last five years. While the overall trend of the proposed models indicates a significant improvement in recognition accuracy in sign language recognition, there are some challenges yet that need to be solved. We present a taxonomy to categorize the proposed models for isolated and continuous sign language recognition, discussing applications, datasets, hybrid models, complexity, and future lines of research in the field.

Abstract: Online continual learning aims to learn from a non-IID stream of data from a number of different tasks, where the learner is only allowed to consider data once. Methods are typically allowed to use a limited buffer to store some of the images in the stream. Recently, it was found that feature replay, where an intermediate layer representation of the image is stored (or generated) leads to superior results than image replay, while requiring less memory. Quantized exemplars can further reduce the memory usage. However, a drawback of these methods is that they use a fixed (or very intransigent) backbone network. This significantly limits the learning of representations that can discriminate between all tasks. To address this problem, we propose an auxiliary classifier auto-encoder (ACAE) module for feature replay at intermediate layers with high compression rates. The reduced memory footprint per image allows us to save more exemplars for replay. In our experiments, we conduct task-agnostic evaluation under online continual learning setting and get state-of-the-art performance on ImageNet-Subset, CIFAR100 and CIFAR10 dataset.

Abstract: Images with visual and scene text content are ubiquitous in everyday life. However, current image interpretation systems are mostly limited to using only the visual features, neglecting to leverage the scene text content. In this paper, we propose to jointly use scene text and visual channels for robust semantic interpretation of images. We do not only extract and encode visual and scene text cues, but also model their interplay to generate a contextual joint embedding with richer semantics. The contextual embedding thus generated is applied to retrieval and classification tasks on multimedia images, with scene text content, to demonstrate its effectiveness. In the retrieval framework, we augment our learned text-visual semantic representation with scene text cues, to mitigate vocabulary misses that may have occurred during the semantic embedding. To deal with irrelevant or erroneous recognition of scene text, we also apply query-based attention to our text channel. We show how the multi-channel approach, involving visual semantics and scene text, improves upon state of the art.

Abstract: Human avatars are important targets in many computer applications. Accurately tracking, capturing, reconstructing and animating the human body, face and garments in 3D are critical for human-computer interaction, gaming, special effects and virtual reality. In the past, this has required extensive manual animation. Regardless of the advances in human body and face reconstruction, still modeling, learning and analyzing human dynamics need further attention. In this paper we plan to push the research in this direction, e.g. understanding human dynamics in 2D and 3D, with special attention to garments. We provide a large-scale dataset (more than 2M frames) of animated garments with variable topology and type, calledCLOTH3D++. The dataset contains RGBA video sequences paired with its corresponding 3D data. We pay special care to garment dynamics and realistic rendering of RGB data, including lighting, fabric type and texture. With this dataset, we hold a competition at NeurIPS2020. We design three tracks so participants can compete to develop the best method to perform 3D garment reconstruction in a sequence from (1) 3D-to-3D garments, (2) RGB-to-3D garments, and (3) RGB-to-3D garments plus texture. We also provide a baseline method, based on graph convolutional networks, for each track. Baseline results show that there is a lot of room for improvements. However, due to the challenging nature of the problem, no participant could outperform the baselines.