Abstract: Many real problems require multi-class decisions. In the Pattern Recognition field,
many techniques have been proposed to deal with the binary problem. However,
the extension of many 2-class classifiers to the multi-class case is a hard task. In
this sense, Error-Correcting Output Codes (ECOC) demonstrated to be a powerful
tool to combine any number of binary classifiers to model multi-class problems. But
there are still many open issues about the capabilities of the ECOC framework. In
this thesis, the two main stages of an ECOC design are analyzed: the coding and
the decoding steps. We present different problem-dependent designs. These designs
take advantage of the knowledge of the problem domain to minimize the number
of classifiers, obtaining a high classification performance. On the other hand, we
analyze the ECOC codification in order to define new decoding rules that take full
benefit from the information provided at the coding step. Moreover, as a successful
classification requires a rich feature set, new feature detection/extraction techniques
are presented and evaluated on the new ECOC designs. The evaluation of the new
methodology is performed on different real and synthetic data sets: UCI Machine
Learning Repository, handwriting symbols, traffic signs from a Mobile Mapping System, Intravascular Ultrasound images, Caltech Repository data set or Chaga’s disease
data set. The results of this thesis show that significant performance improvements
are obtained on both traditional coding and decoding ECOC designs when the new
coding and decoding rules are taken into account.

Abstract: Early diagnosis and accurate treatment of Left Ventricle (LV) dysfunction significantly increases the patient survival. Impairment of LV contractility due to cardiovascular diseases is reflected in its motion patterns. Recent advances in medical imaging, such as Magnetic Resonance (MR), have encouraged research on 3D simulation and modelling of the LV dynamics. Most of the existing 3D models [1] consider just the gross anatomy of the LV and restore a truncated ellipse which deforms along the cardiac cycle. The contraction mechanics of any muscle strongly depends on the spatial orientation of its muscular fibers since the motion that the muscle undergoes mainly takes place along the fibers. It follows that such simplified models do not allow evaluation of the heart electro-mechanical function and coupling, which has recently risen as the key point for understanding the LV functionality [2]. In order to thoroughly understand the LV mechanics it is necessary to consider the complete anatomy of the LV given by the orientation of the myocardial fibres in 3D space as described by Torrent Guasp [3].
We propose developing a 3D patient-sensitive model of the LV integrating, for the first time, the ven- tricular band anatomy (fibers orientation), the LV gross anatomy and its functionality. Such model will represent the LV function as a natural consequence of its own ventricular band anatomy. This might be decisive in restoring a proper LV contraction in patients undergoing pace marker treatment.
The LV function is defined as soon as the propagation of the contractile electromechanical pulse has been modelled. In our experiments we have used the wave equation for the propagation of the electric pulse. The electromechanical wave moves on the myocardial surface and should have a conductivity tensor oriented along the muscular fibers. Thus, whatever mathematical model for electric pulse propa- gation [4] we consider, the complete anatomy of the LV should be extracted.
The LV gross anatomy is obtained by processing multi slice MR images recorded for each patient. Information about the myocardial fibers distribution can only be extracted by Diffusion Tensor Imag- ing (DTI), which can not provide in vivo information for each patient. As a first approach, we have
Figure 1: Scheme for the Left Ventricle Patient-Sensitive Model.
computed an average model of fibers from several DTI studies of canine hearts. This rough anatomy is the input for our electro-mechanical propagation model simulating LV dynamics. The average fiber orientation is updated until the simulated LV motion agrees with the experimental evidence provided by the LV motion observed in tagged MR (TMR) sequences. Experimental LV motion is recovered by applying image processing, differential geometry and interpolation techniques to 2D TMR slices [5]. The pipeline in figure 1 outlines the interaction between simulations and experimental data leading to our patient-tailored model.