Abstract: This paper presents a patient-sensitive simulation strategy capable of using the most efficient way the high-performance computational resources. The proposed strategy directly involves three different players: Computational Mechanics Scientists (CMS), Image Processing Scientists and Cardiologists, each one mastering its own expertise area within the project. This paper describes the general integrative scheme but focusing on the CMS side presents a massively parallel implementation of computational electrophysiology applied to cardiac tissue simulation. The paper covers different angles of the computational problem: equations, numerical issues, the algorithm and parallel implementation. The proposed methodology is illustrated with numerical simulations testing all the different possibilities, ranging from small domains up to very large ones. A key issue is the almost ideal scalability not only for large and complex problems but also for medium-size meshes. The explicit formulation is particularly well suited for solving this highly transient problems, with very short time-scale.

Abstract: Intestinal motility assessment with video capsule endoscopy arises as a novel and challenging clinical fieldwork. This technique is based on the analysis of the patterns of intestinal contractions obtained by labelling all the motility events present in a video provided by a capsule with a wireless micro-camera, which is ingested by the patient. However, the visual analysis of these video sequences presents several im- portant drawbacks, mainly related to both the large amount of time needed for the visualization process, and the low prevalence of intestinal contractions in video.
In this work we propose a machine learning system to automatically detect the intestinal contractions in video capsule endoscopy, driving a very useful but not fea- sible clinical routine into a feasible clinical procedure. Our proposal is divided into two different parts: The first part tackles the problem of the automatic detection of phasic contractions in capsule endoscopy videos. Phasic contractions are dynamic events spanning about 4-5 seconds, which show visual patterns with a high variability. Our proposal is based on a sequential design which involves the analysis of textural, color and blob features with powerful classifiers such as SVM. This approach appears to cope with two basic aims: the reduction of the imbalance rate of the data set, and the modular construction of the system, which adds the capability of including domain knowledge as new stages in the cascade. The second part of the current work tackles the problem of the automatic detection of tonic contractions. Tonic contrac- tions manifest in capsule endoscopy as a sustained pattern of the folds and wrinkles of the intestine, which may be prolonged for an undetermined span of time. Our proposal is based on the analysis of the wrinkle patterns, presenting a comparative study of diverse features and classification methods, and providing a set of appro- priate descriptors for their characterization. We provide a detailed analysis of the performance achieved by our system both in a qualitative and a quantitative way.

Abstract: In this paper we tackle the problem of document image retrieval by combining a similarity measure between documents and the probability that a given document belongs to a certain class. The membership probability to a specific class is computed using Support Vector Machines in conjunction with similarity measure based kernel applied to structural document representations. In the presented experiments, we use different document representations, both visual and structural, and we apply them to a database of historical documents. We show how our method based on similarity kernels outperforms the usual distance-based retrieval.