Home | << 1 >> |
Record | |||||
---|---|---|---|---|---|
Author | Frederic Sampedro; Anna Domenech; Sergio Escalera | ||||
Title | Obtaining quantitative global tumoral state indicators based on whole-body PET/CT scans: A breast cancer case study | Type | Journal Article | ||
Year | 2014 | Publication | Nuclear Medicine Communications | Abbreviated Journal | NMC |
Volume | 35 | Issue | 4 | Pages | 362-371 |
Keywords | |||||
Abstract | Objectives: In this work we address the need for the computation of quantitative global tumoral state indicators from oncological whole-body PET/computed tomography scans. The combination of such indicators with other oncological information such as tumor markers or biopsy results would prove useful in oncological decision-making scenarios.
Materials and methods: From an ordering of 100 breast cancer patients on the basis of oncological state through visual analysis by a consensus of nuclear medicine specialists, a set of numerical indicators computed from image analysis of the PET/computed tomography scan is presented, which attempts to summarize a patient’s oncological state in a quantitative manner taking into consideration the total tumor volume, aggressiveness, and spread. Results: Results obtained by comparative analysis of the proposed indicators with respect to the experts’ evaluation show up to 87% Pearson’s correlation coefficient when providing expert-guided PET metabolic tumor volume segmentation and 64% correlation when using completely automatic image analysis techniques. Conclusion: Global quantitative tumor information obtained by whole-body PET/CT image analysis can prove useful in clinical nuclear medicine settings and oncological decision-making scenarios. The completely automatic computation of such indicators would improve its impact as time efficiency and specialist independence would be achieved. |
||||
Address | |||||
Corporate Author | Thesis | ||||
Publisher | Place of Publication | Editor | |||
Language | Summary Language | Original Title | |||
Series Editor | Series Title | Abbreviated Series Title | |||
Series Volume | Series Issue | Edition | |||
ISSN | ISBN | Medium | |||
Area | Expedition | Conference | |||
Notes | HuPBA;MILAB | Approved | no | ||
Call Number | SDE2014a | Serial | 2444 | ||
Permanent link to this record |