Abstract: To recognise objects is perhaps the most important task an autonomous system, either biological or artificial needs to perform. In the context of human vision, this is partly achieved by recognizing the colour of surfaces despite changes in the wavelength distribution of the illumination, a property called colour constancy. Correct surface colour recognition may be adequately accomplished by colour category matching without the need to match colours precisely, therefore categorical colour constancy is likely to play an important role for object identification to be successful. The main aim of this work is to study the relationship between colour constancy and categorical colour perception. Previous studies of colour constancy have shown the influence of factors such the spatio-chromatic properties of the background, individual observer's performance, semantics, etc. However there is very little systematic study of these influences. To this end, we developed a new approach to colour constancy which includes both individual observers' categorical perception, the categorical structure of the background, and their interrelations resulting in a more comprehensive characterization of the phenomenon. In our study, we first developed a new method to analyse the categorical structure of 3D colour space, which allowed us to characterize individual categorical colour perception as well as quantify inter-individual variations in terms of shape and centroid location of 3D categorical regions. Second, we developed a new colour constancy paradigm, termed chromatic setting, which allows measuring the precise location of nine categorically-relevant points in colour space under immersive illumination. Additionally, we derived from these measurements a new colour constancy index which takes into account the magnitude and orientation of the chromatic shift, memory effects and the interrelations among colours and a model of colour naming tuned to each observer/adaptation state. Our results lead to the following conclusions: (1) There exists large inter-individual variations in the categorical structure of colour space, and thus colour naming ability varies significantly but this is not well predicted by low-level chromatic discrimination ability; (2) Analysis of the average colour naming space suggested the need for an additional three basic colour terms (turquoise, lilac and lime) for optimal colour communication; (3) Chromatic setting improved the precision of more complex linear colour constancy models and suggested that mechanisms other than cone gain might be best suited to explain colour constancy; (4) The categorical structure of colour space is broadly stable under illuminant changes for categorically balanced backgrounds; (5) Categorical inconstancy exists for categorically unbalanced backgrounds thus indicating that categorical information perceived in the initial stages of adaptation may constrain further categorical perception.

Abstract: Medial representations are powerful tools for describing and parameterizing the volumetric shape of anatomical structures. Existing methods show excellent results when applied to 2D
objects, but their quality drops across dimensions. This paper contributes to the computation of medial manifolds in two aspects. First, we provide a standard scheme for the computation of medial
manifolds that avoid degenerated medial axis segments; second, we introduce an energy based method which performs independently of the dimension. We evaluate quantitatively the performance of our
method with respect to existing approaches, by applying them to synthetic shapes of known medial geometry. Finally, we show results on shape representation of multiple abdominal organs,
exploring the use of medial manifolds for the representation of multi-organ relations.

Abstract: The operational model of agonism has been widely used for the analysis of agonist action since its formulation in 1983. The model includes the Em parameter, which is defined as the maximum response of the system. The methods for Em estimation provide Em values not significantly higher than the maximum responses achieved by full agonists. However, it has been found that that some classes of compounds as, for instance, superagonists and positive allosteric modulators can increase the full agonist maximum response, implying upper limits for Em and thereby posing doubts on the validity of Em estimates. Because of the correlation between Em and operational efficacy, τ, wrong Em estimates will yield wrong τ estimates.
In this presentation, the operational model of agonism and various methods for the simulation of allosteric modulation will be analyzed. Alternatives for curve fitting will be presented and discussed.