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| Author | Carolina Malagelada; F.De Lorio; Santiago Segui; S. Mendez; Michal Drozdzal; Jordi Vitria; Petia Radeva; J.Santos; Anna Accarino; Juan R. Malagelada; Fernando Azpiroz | ||||
| Title | Functional gut disorders or disordered gut function? Small bowel dysmotility evidenced by an original technique | Type | Journal Article | ||
| Year | 2012 | Publication | Neurogastroenterology & Motility | Abbreviated Journal | NEUMOT |
| Volume | 24 | Issue | 3 | Pages | 223-230 |
| Keywords | capsule endoscopy;computer vision analysis;machine learning technique;small bowel motility | ||||
| Abstract | JCR Impact Factor 2010: 3.349
Background This study aimed to determine the proportion of cases with abnormal intestinal motility among patients with functional bowel disorders. To this end, we applied an original method, previously developed in our laboratory, for analysis of endoluminal images obtained by capsule endoscopy. This novel technology is based on computer vision and machine learning techniques. Methods The endoscopic capsule (Pillcam SB1; Given Imaging, Yokneam, Israel) was administered to 80 patients with functional bowel disorders and 70 healthy subjects. Endoluminal image analysis was performed with a computer vision program developed for the evaluation of contractile events (luminal occlusions and radial wrinkles), non-contractile patterns (open tunnel and smooth wall patterns), type of content (secretions, chyme) and motion of wall and contents. Normality range and discrimination of abnormal cases were established by a machine learning technique. Specifically, an iterative classifier (one-class support vector machine) was applied in a random population of 50 healthy subjects as a training set and the remaining subjects (20 healthy subjects and 80 patients) as a test set. Key Results The classifier identified as abnormal 29% of patients with functional diseases of the bowel (23 of 80), and as normal 97% of healthy subjects (68 of 70) (P < 0.05 by chi-squared test). Patients identified as abnormal clustered in two groups, which exhibited either a hyper- or a hypodynamic motility pattern. The motor behavior was unrelated to clinical features. Conclusions & Inferences With appropriate methodology, abnormal intestinal motility can be demonstrated in a significant proportion of patients with functional bowel disorders, implying a pathologic disturbance of gut physiology. |
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| Publisher | Wiley Online Library | Place of Publication | Editor | ||
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| Notes | MILAB; OR; MV | Approved | no | ||
| Call Number | Admin @ si @ MLS2012 | Serial | 1830 | ||
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