Abstract: A method for automatically detecting a post-duodenal boundary in an image stream of the gastrointestinal (GI) tract. The image stream is sampled to obtain a reduced set of images for processing. The reduced set of images is filtered to remove non-valid frames or non-valid portions of frames, thereby generating a filtered set of valid images. A polar representation of the valid images is generated. Textural features of the polar representation are processed to detect the post-duodenal boundary of the GI tract.