Abstract: This work aims at the segmentation of colonoscopy images into a minimum number of informative regions. Our method performs in a way such, if a polyp is present in the image, it will be exclusively and totally contained in a single region. This result can be used in later stages to classify regions as polyp-containing candidates. The output of the algorithm also defines which regions can be considered as non-informative. The algorithm starts with a high number of initial regions and merges them taking into account the model of polyp appearance obtained from available data. The results show that our segmentations of polyp regions are more accurate than state-of-the-art methods.

Abstract: Medial representations are powerful tools for describing and parameterizing the volumetric shape of anatomical structures. Existing methods show excellent results when applied to 2D
objects, but their quality drops across dimensions. This paper contributes to the computation of medial manifolds in two aspects. First, we provide a standard scheme for the computation of medial
manifolds that avoid degenerated medial axis segments; second, we introduce an energy based method which performs independently of the dimension. We evaluate quantitatively the performance of our
method with respect to existing approaches, by applying them to synthetic shapes of known medial geometry. Finally, we show results on shape representation of multiple abdominal organs,
exploring the use of medial manifolds for the representation of multi-organ relations.

Abstract: Optical flow is a valuable tool for motion analysis in medical imaging sequences. A reliable application requires determining the accuracy of the computed optical flow. This is a main challenge given the absence of ground truth in medical sequences. This paper presents an error analysis of Lucas-Kanade schemes in terms of intrinsic design errors and numerical stability of the algorithm. Our analysis provides a confidence measure that is naturally correlated to the accuracy of the flow field. Our experiments show the higher predictive value of our confidence measure compared to existing measures.

Abstract: Medial representations are a widely used technique in abdominal organ shape representation and parametrization. Those methods require good medial manifolds as a starting point. Any medial
surface used to parametrize a volume should be simple enough to allow an easy manipulation and complete enough to allow an accurate reconstruction of the volume. Obtaining good quality medial
surfaces is still a problem with current iterative thinning methods. This forces the usage of generic, pre-calculated medial templates that are adapted to the final shape at the cost of a drop in volume reconstruction.
This paper describes an operator for generation of medial structures that generates clean and complete manifolds well suited for their further use in medial representations of abdominal organ volumes. While being simpler than thinning surfaces, experiments show its high performance in volume reconstruction and preservation of medial surface main branching topology.

Abstract: Breast cancer disease has recently been classified into four subtypes regarding the molecular properties of the affected tumor region. For each patient, an accurate diagnosis of the specific type is vital to decide the most appropriate therapy in order to enhance life prospects. Nowadays, advanced therapeutic diagnosis research is focused on gene selection methods, which are not robust enough. Hence, we hypothesize that computer vision algorithms can offer benefits to address the problem of discriminating among them through X-Ray images. In this paper, we propose a novel approach driven by texture feature descriptors and machine learning techniques. First, we segment the tumour part through an active contour technique and then, we perform a complete fractal analysis to collect qualitative information of the region of interest in the feature extraction stage. Finally, several supervised and unsupervised classifiers are used to perform multiclass classification of the aforementioned data. The experimental results presented in this paper support that it is possible to establish a relation between each tumor subtype and the extracted features of the patterns revealed on mammograms.

Abstract: Three-dimensional intravascular ultrasound (IVUS) allows to visualize and obtain volumetric measurements of coronary lesions through an exploration of the cross sections and longitudinal views of arteries. However, the visualization and subsequent morpho-geometric measurements in IVUS longitudinal cuts are subject to distortion caused by periodic image/vessel motion around the IVUS catheter. Usually, to overcome the image motion artifact ECG-gating and image-gated approaches are proposed, leading to slowing the pullback acquisition or disregarding part of IVUS data. In this paper, we argue that the image motion is due to 3-D vessel geometry as well as cardiac dynamics, and propose a dynamic model based on the tracking of an elliptical vessel approximation to recover the rigid transformation and align IVUS images without loosing any IVUS data. We report an extensive validation with synthetic simulated data and in vivo IVUS sequences of 30 patients achieving an average reduction of the image artifact of 97% in synthetic data and 79% in real-data. Our study shows that IVUS alignment improves longitudinal analysis of the IVUS data and is a necessary step towards accurate reconstruction and volumetric measurements of 3-D IVUS.