Abstract: The human visual system is not a colorimeter. The perceived colour of a region does not only depend on its colour spectrum, but also on the colour spectra and geometric arrangement of neighbouring regions, a phenomenon called chromatic induction. Chromatic induction is thought to be driven by lateral interactions: the activity of a central neuron is modified by stimuli outside its classical receptive field through excitatory–inhibitory mechanisms. As there is growing evidence of an excitation/inhibition imbalance in migraine, we compared chromatic induction in migraine and control groups. As hypothesised, we found a difference in the strength of induction between the two groups, with stronger induction effects in migraine. On the other hand, given the increased prevalence of visual phenomena in migraine with aura, we also hypothesised that the difference between migraine and control would be more important in migraine with aura than in migraine without aura. Our experiments did not support this hypothesis. Taken together, our results suggest a link between excitation/inhibition imbalance and increased induction effects.

Abstract: Background Reliable predictive imaging markers of response to immune checkpoint inhibitors are needed. Purpose To develop and validate a pretreatment CT-based radiomics signature to predict response to immune checkpoint inhibitors in advanced solid tumors. Materials and Methods In this retrospective study, a radiomics signature was developed in patients with advanced solid tumors (including breast, cervix, gastrointestinal) treated with anti-programmed cell death-1 or programmed cell death ligand-1 monotherapy from August 2012 to May 2018 (cohort 1). This was tested in patients with bladder and lung cancer (cohorts 2 and 3). Radiomics variables were extracted from all metastases delineated at pretreatment CT and selected by using an elastic-net model. A regression model combined radiomics and clinical variables with response as the end point. Biologic validation of the radiomics score with RNA profiling of cytotoxic cells (cohort 4) was assessed with Mann-Whitney analysis. Results The radiomics signature was developed in 85 patients (cohort 1: mean age, 58 years ± 13 [standard deviation]; 43 men) and tested on 46 patients (cohort 2: mean age, 70 years ± 12; 37 men) and 47 patients (cohort 3: mean age, 64 years ± 11; 40 men). Biologic validation was performed in a further cohort of 20 patients (cohort 4: mean age, 60 years ± 13; 14 men). The radiomics signature was associated with clinical response to immune checkpoint inhibitors (area under the curve [AUC], 0.70; 95% CI: 0.64, 0.77; P < .001). In cohorts 2 and 3, the AUC was 0.67 (95% CI: 0.58, 0.76) and 0.67 (95% CI: 0.56, 0.77; P < .001), respectively. A radiomics-clinical signature (including baseline albumin level and lymphocyte count) improved on radiomics-only performance (AUC, 0.74 [95% CI: 0.63, 0.84; P < .001]; Akaike information criterion, 107.00 and 109.90, respectively). Conclusion A pretreatment CT-based radiomics signature is associated with response to immune checkpoint inhibitors, likely reflecting the tumor immunophenotype. © RSNA, 2021 Online supplemental material is available for this article. See also the editorial by Summers in this issue.

Abstract: In the film industry, the same movie is expected to be watched on displays of vastly different sizes, from cinema screens to mobile phones. But visual induction, the perceptual phenomenon by which the appearance of a scene region is affected by its surroundings, will be different for the same image shown on two displays of different dimensions. This phenomenon presents a practical challenge for the preservation of the artistic intentions of filmmakers, because it can lead to shifts in image appearance between viewing destinations. In this work, we show that a neural field model based on the efficient representation principle is able to predict induction effects and how, by regularizing its associated energy functional, the model is still able to represent induction but is now invertible. From this finding, we propose a method to preprocess an image in a screen–size dependent way so that its perception, in terms of visual induction, may remain constant across displays of different size. The potential of the method is demonstrated through psychophysical experiments on synthetic images and qualitative examples on natural images.

Abstract: Generative Adversarial Networks have long since revolutionized the world of computer vision and, tied to it, the world of art. Arduous efforts have gone into fully utilizing and stabilizing training so that outputs of the Generator network have the highest possible fidelity, but little has gone into using the Discriminator after training is complete. In this work, we propose to use the latter and show a way to use the features it has learned from the training dataset to both alter an image and generate one from scratch. We name this method Discriminator Dreaming, and the full code can be found at this https URL.

Abstract: Manually annotating images to develop vision models has been a major bottleneck
since computer vision and machine learning started to walk together. This has
been more evident since computer vision falls on the shoulders of data-hungry
deep learning techniques. When addressing on-board perception for autonomous
driving, the curse of data annotation is exacerbated due to the use of additional
sensors such as LiDAR. Therefore, any approach aiming at reducing such a timeconsuming and costly work is of high interest for addressing autonomous driving
and, in fact, for any application requiring some sort of artificial perception. In the
last decade, it has been shown that leveraging from synthetic data is a paradigm
worth to pursue in order to minimizing manual data annotation. The reason is
that the automatic process of generating synthetic data can also produce different
types of associated annotations (e.g. object bounding boxes for synthetic images
and LiDAR pointclouds, pixel/point-wise semantic information, etc.). Directly
using synthetic data for training deep perception models may not be the definitive
solution in all circumstances since it can appear a synth-to-real domain shift. In
this context, this work focuses on leveraging synthetic data to alleviate manual
annotation for three perception tasks related to driving assistance and autonomous
driving. In all cases, we assume the use of deep convolutional neural networks
(CNNs) to develop our perception models.
The first task addresses traffic sign recognition (TSR), a kind of multi-class
classification problem. We assume that the number of sign classes to be recognized
must be suddenly increased without having annotated samples to perform the
corresponding TSR CNN re-training. We show that leveraging synthetic samples of
such new classes and transforming them by a generative adversarial network (GAN)
trained on the known classes (i.e. without using samples from the new classes), it is
possible to re-train the TSR CNN to properly classify all the signs for a ∼ 1/4 ratio of
new/known sign classes. The second task addresses on-board 2D object detection,
focusing on vehicles and pedestrians. In this case, we assume that we receive a set
of images without the annotations required to train an object detector, i.e. without
object bounding boxes. Therefore, our goal is to self-annotate these images so
that they can later be used to train the desired object detector. In order to reach
this goal, we leverage from synthetic data and propose a semi-supervised learning
approach based on the co-training idea. In fact, we use a GAN to reduce the synthto-real domain shift before applying co-training. Our quantitative results show
that co-training and GAN-based image-to-image translation complement each
other up to allow the training of object detectors without manual annotation, and still almost reaching the upper-bound performances of the detectors trained from
human annotations. While in previous tasks we focus on vision-based perception,
the third task we address focuses on LiDAR pointclouds. Our initial goal was to
develop a 3D object detector trained on synthetic LiDAR-style pointclouds. While
for images we may expect synth/real-to-real domain shift due to differences in
their appearance (e.g. when source and target images come from different camera
sensors), we did not expect so for LiDAR pointclouds since these active sensors
factor out appearance and provide sampled shapes. However, in practice, we have
seen that it can be domain shift even among real-world LiDAR pointclouds. Factors
such as the sampling parameters of the LiDARs, the sensor suite configuration onboard the ego-vehicle, and the human annotation of 3D bounding boxes, do induce
a domain shift. We show it through comprehensive experiments with different
publicly available datasets and 3D detectors. This redirected our goal towards the
design of a GAN for pointcloud-to-pointcloud translation, a relatively unexplored
topic.
Finally, it is worth to mention that all the synthetic datasets used for these three
tasks, have been designed and generated in the context of this PhD work and will
be publicly released. Overall, we think this PhD presents several steps forward to
encourage leveraging synthetic data for developing deep perception models in the
field of driving assistance and autonomous driving.

Abstract: Word spotting can be defined as the pattern recognition tasked aimed at locating and retrieving a specific keyword within a document image collection without explicitly transcribing the whole corpus. Its use is particularly interesting when applied in scenarios where Optical Character Recognition performs poorly or can not be used at all. This thesis focuses on such a scenario, word spotting on historical handwritten documents that have been written by a single author or by multiple authors with a similar calligraphy.
This problem requires a visual signature that is robust to image artifacts, flexible to accommodate script variations and efficient to retrieve information in a rapid manner. For this, we have developed a set of word spotting methods that on their foundation use the well known Bag-of-Visual-Words (BoVW) representation. This representation has gained popularity among the document image analysis community to characterize handwritten words
in an unsupervised manner. However, most approaches on this field rely on a basic BoVW configuration and disregard complex encoding and spatial representations. We determine which BoVW configurations provide the best performance boost to a spotting system.
Then, we extend the segmentation-based word spotting, where word candidates are given a priori, to segmentation-free spotting. The proposed approach seeds the document images with overlapping word location candidates and characterizes them with a BoVW signature. Retrieval is achieved comparing the query and candidate signatures and returning the locations that provide a higher consensus. This is a simple but powerful approach that requires a more compact signature than in a segmentation-based scenario. We first
project the BoVW signature into a reduced semantic topics space and then compress it further using Product Quantizers. The resulting signature only requires a few dozen bytes, allowing us to index thousands of pages on a common desktop computer. The final system still yields a performance comparable to the state-of-the-art despite all the information loss during the compression phases.
Afterwards, we also study how to combine different modalities of information in order to create a query-by-X spotting system where, words are indexed using an information modality and queries are retrieved using another. We consider three different information modalities: visual, textual and audio. Our proposal is to create a latent feature space where features which are semantically related are projected onto the same topics. Creating thus a new feature space where information from different modalities can be compared. Later, we consider the codebook generation and descriptor encoding problem. The codebooks used to encode the BoVW signatures are usually created using an unsupervised clustering algorithm and, they require to test multiple parameters to determine which configuration is best for a certain document collection. We propose a semantic clustering algorithm which allows to estimate the best parameter from data. Since gather annotated data is costly, we use synthetically generated word images. The resulting codebook is database agnostic, i. e. a codebook that yields a good performance on document collections that use the same script. We also propose the use of an additional codebook to approximate descriptors and reduce the descriptor encoding
complexity to sub-linear.
Finally, we focus on the problem of signatures dimensionality. We propose a new symbol probability signature where each bin represents the probability that a certain symbol is present a certain location of the word image. This signature is extremely compact and combined with compression techniques can represent word images with just a few bytes per signature.

Abstract: Image-to-image (I2I) translation has matured in recent years and is able to generate high-quality realistic images. However, despite current success, it still faces important challenges when applied to small domains. Existing methods use transfer learning for I2I translation, but they still require the learning of millions of parameters from scratch. This drawback severely limits its application on small domains. In this paper, we propose a new transfer learning for I2I translation (TransferI2I). We decouple our learning process into the image generation step and the I2I translation step. In the first step we propose two novel techniques: source-target initialization and self-initialization of the adaptor layer. The former finetunes the pretrained generative model (e.g., StyleGAN) on source and target data. The latter allows to initialize all non-pretrained network parameters without the need of any data. These techniques provide a better initialization for the I2I translation step. In addition, we introduce an auxiliary GAN that further facilitates the training of deep I2I systems even from small datasets. In extensive experiments on three datasets, (Animal faces, Birds, and Foods), we show that we outperform existing methods and that mFID improves on several datasets with over 25 points.