Abstract: Background Reliable predictive imaging markers of response to immune checkpoint inhibitors are needed. Purpose To develop and validate a pretreatment CT-based radiomics signature to predict response to immune checkpoint inhibitors in advanced solid tumors. Materials and Methods In this retrospective study, a radiomics signature was developed in patients with advanced solid tumors (including breast, cervix, gastrointestinal) treated with anti-programmed cell death-1 or programmed cell death ligand-1 monotherapy from August 2012 to May 2018 (cohort 1). This was tested in patients with bladder and lung cancer (cohorts 2 and 3). Radiomics variables were extracted from all metastases delineated at pretreatment CT and selected by using an elastic-net model. A regression model combined radiomics and clinical variables with response as the end point. Biologic validation of the radiomics score with RNA profiling of cytotoxic cells (cohort 4) was assessed with Mann-Whitney analysis. Results The radiomics signature was developed in 85 patients (cohort 1: mean age, 58 years ± 13 [standard deviation]; 43 men) and tested on 46 patients (cohort 2: mean age, 70 years ± 12; 37 men) and 47 patients (cohort 3: mean age, 64 years ± 11; 40 men). Biologic validation was performed in a further cohort of 20 patients (cohort 4: mean age, 60 years ± 13; 14 men). The radiomics signature was associated with clinical response to immune checkpoint inhibitors (area under the curve [AUC], 0.70; 95% CI: 0.64, 0.77; P < .001). In cohorts 2 and 3, the AUC was 0.67 (95% CI: 0.58, 0.76) and 0.67 (95% CI: 0.56, 0.77; P < .001), respectively. A radiomics-clinical signature (including baseline albumin level and lymphocyte count) improved on radiomics-only performance (AUC, 0.74 [95% CI: 0.63, 0.84; P < .001]; Akaike information criterion, 107.00 and 109.90, respectively). Conclusion A pretreatment CT-based radiomics signature is associated with response to immune checkpoint inhibitors, likely reflecting the tumor immunophenotype. © RSNA, 2021 Online supplemental material is available for this article. See also the editorial by Summers in this issue.

Abstract: Top-performing computer vision models are powered by convolutional neural networks (CNNs). Training an accurate CNN highly depends on both the raw sensor data and their associated ground truth (GT). Collecting such GT is usually done through human labeling, which is time-consuming and does not scale as we wish. This data-labeling bottleneck may be intensified due to domain shifts among image sensors, which could force per-sensor data labeling. In this paper, we focus on the use of co-training, a semi-supervised learning (SSL) method, for obtaining self-labeled object bounding boxes (BBs), i.e., the GT to train deep object detectors. In particular, we assess the goodness of multi-modal co-training by relying on two different views of an image, namely, appearance (RGB) and estimated depth (D). Moreover, we compare appearance-based single-modal co-training with multi-modal. Our results suggest that in a standard SSL setting (no domain shift, a few human-labeled data) and under virtual-to-real domain shift (many virtual-world labeled data, no human-labeled data) multi-modal co-training outperforms single-modal. In the latter case, by performing GAN-based domain translation both co-training modalities are on par, at least when using an off-the-shelf depth estimation model not specifically trained on the translated images.

Abstract: Human visual perception is limited to the visual-optical spectrum. Machine vision is not. Cameras sensitive to the different infrared spectra can enhance the abilities of autonomous systems and visually perceive the environment in a holistic way. Relevant scene content can be made visible especially in situations, where sensors of other modalities face issues like a visual-optical camera that needs a source of illumination. As a consequence, not only human mistakes can be avoided by increasing the level of automation, but also machine-induced errors can be reduced that, for example, could make a self-driving car crash into a pedestrian under difficult illumination conditions. Furthermore, multi-spectral sensor systems with infrared imagery as one modality are a rich source of information and can provably increase the robustness of many autonomous systems. Applications that can benefit from utilizing infrared imagery range from robotics to automotive and from biometrics to surveillance. In this book, we provide a brief yet concise introduction to the current state-of-the-art of computer vision and machine learning in the infrared spectrum. Based on various popular computer vision tasks such as image enhancement, object detection, or object tracking, we first motivate each task starting from established literature in the visual-optical spectrum. Then, we discuss the differences between processing images and videos in the visual-optical spectrum and the various infrared spectra. An overview of the current literature is provided together with an outlook for each task. Furthermore, available and annotated public datasets and common evaluation methods and metrics are presented. In a separate chapter, popular applications that can greatly benefit from the use of infrared imagery as a data source are presented and discussed. Among them are automatic target recognition, video surveillance, or biometrics including face recognition. Finally, we conclude with recommendations for well-fitting sensor setups and data processing algorithms for certain computer vision tasks. We address this book to prospective researchers and engineers new to the field but also to anyone who wants to get introduced to the challenges and the approaches of computer vision using infrared images or videos. Readers will be able to start their work directly after reading the book supported by a highly comprehensive backlog of recent and relevant literature as well as related infrared datasets including existing evaluation frameworks. Together with consistently decreasing costs for infrared cameras, new fields of application appear and make computer vision in the infrared spectrum a great opportunity to face nowadays scientific and engineering challenges.

Abstract: Domain adaptation (DA) aims to alleviate the domain shift between source domain and target domain. Most DA methods require access to the source data, but often that is not possible (e.g. due to data privacy or intellectual property). In this paper, we address the challenging source-free domain adaptation (SFDA) problem, where the source pretrained model is adapted to the target domain in the absence of source data. Our method is based on the observation that target data, which might no longer align with the source domain classifier, still forms clear clusters. We capture this intrinsic structure by defining local affinity of the target data, and encourage label consistency among data with high local affinity. We observe that higher affinity should be assigned to reciprocal neighbors, and propose a self regularization loss to decrease the negative impact of noisy neighbors. Furthermore, to aggregate information with more context, we consider expanded neighborhoods with small affinity values. In the experimental results we verify that the inherent structure of the target features is an important source of information for domain adaptation. We demonstrate that this local structure can be efficiently captured by considering the local neighbors, the reciprocal neighbors, and the expanded neighborhood. Finally, we achieve state-of-the-art performance on several 2D image and 3D point cloud recognition datasets. Code is available in https://github.com/Albert0147/SFDA_neighbors.