Abstract: Pedestrian detection is of paramount interest for many applications, e.g. Advanced Driver Assistance Systems, Intelligent Video Surveillance and Multimedia systems. Most promising pedestrian detectors rely on appearance-based classifiers trained with annotated data. However, the required annotation step represents an intensive and subjective task for humans, what makes worth to minimize their intervention in this process by using computational tools like realistic virtual worlds. The reason to use these kind of tools relies in the fact that they allow the automatic generation of precise and rich annotations of visual information. Nevertheless, the use of this kind of data comes with the following question: can a pedestrian appearance model learnt with virtual-world data work successfully for pedestrian detection in real-world scenarios?. To answer this question, we conduct different experiments that suggest a positive answer. However, the pedestrian classifiers trained with virtual-world data can suffer the so called dataset shift problem as real-world based classifiers does. Accordingly, we have designed different domain adaptation techniques to face this problem, all of them integrated in a same framework (V-AYLA). We have explored different methods to train a domain adapted pedestrian classifiers by collecting a few pedestrian samples from the target domain (real world) and combining them with many samples of the source domain (virtual world). The extensive experiments we present show that pedestrian detectors developed within the V-AYLA framework do achieve domain adaptation. Ideally, we would like to adapt our system without any human intervention. Therefore, as a first proof of concept we also propose an unsupervised domain adaptation technique that avoids human intervention during the adaptation process. To the best of our knowledge, this Thesis work is the first demonstrating adaptation of virtual and real worlds for developing an object detector. Last but not least, we also assessed a different strategy to avoid the dataset shift that consists in collecting real-world samples and retrain with them in such a way that no bounding boxes of real-world pedestrians have to be provided. We show that the generated classifier is competitive with respect to the counterpart trained with samples collected by manually annotating pedestrian bounding boxes. The results presented on this Thesis not only end with a proposal for adapting a virtual-world pedestrian detector to the real world, but also it goes further by pointing out a new methodology that would allow the system to adapt to different situations, which we hope will provide the foundations for future research in this unexplored area.

Abstract: Medical imaging feeds research in many computer vision and image processing fields: image filtering, segmentation, shape recovery, registration, retrieval and pattern matching. Because of their low contrast changes and large variety of artifacts and noise, medical imaging processing techniques relying on an analysis of the geometry of image level sets rather than on intensity values result in more robust treatment. From the starting point of treatment of intravascular images, this PhD thesis ad- dresses the design of differential image operators based on geometric principles for a robust shape modelling and restoration. Among all fields applying shape recovery, we approach filtering and segmentation of image objects. For a successful use in real images, the segmentation process should go through three stages: noise removing, shape modelling and shape recovery. This PhD addresses all three topics, but for the sake of algorithms as automated as possible, techniques for image processing will be designed to satisfy three main principles: a) convergence of the iterative schemes to non-trivial states avoiding image degeneration to a constant image and representing smooth models of the originals; b) smooth asymptotic behav- ior ensuring stabilization of the iterative process; c) fixed parameter values ensuring equal (domain free) performance of the algorithms whatever initial images/shapes. Our geometric approach to the generic equations that model the different processes approached enables defining techniques satisfying all the former requirements. First, we introduce a new curvature-based geometric flow for image filtering achieving a good compromise between noise removing and resemblance to original images. Sec- ond, we describe a new family of diffusion operators that restrict their scope to image level curves and serve to restore smooth closed models from unconnected sets of points. Finally, we design a regularization of snake (distance) maps that ensures its smooth convergence towards any closed shape. Experiments show that performance of the techniques proposed overpasses that of state-of-the-art algorithms.

Abstract: La valoració de la integritat de la microcirculació coronària aporta informació pronòstica en pacients amb infart agut de miocardi en els que es realitza angioplastia primària. Aquesta valoració és subjectiva i presenta una important variabilitat si no es duta a terme per personal experimentat. Presentem una eina d’anàlisi d’imatge que permet fer una valoració de la microcirculació coronària a partir de seqüències d’angiografia. Hem analitzat les variacions locals en el nivell de gris de la imatge durant la seqüència angiogràfica. Hem identificat els principals fenòmens observats (respiració, batec cardíac, tinció arterial, tinció miocàrdica i soroll radiològic) mitjançant un anàlisi estadístic de l’espectre de Fourier de l’evolució al llarg del temps de la mitja local. Aquest mateix anàlisis permet determinat la influència de cadascun d’ells en la extracció del patró de tinció i selecciona la respiració com el fenomen que més distorsiona el patró de tinció original. Els descriptors proposats s’obtenen fora del rang espectral respiratori. Hem testat la seva capacitat per a detectar els tres fenòmens principals (tinció miocàrdica (MS), tinció arterial (AS) i soroll (NS)) independentment de la respiració. La capacitat de discriminació dels descriptors ha estat valorada mitjançant un mètode de crossvalidation en 30 seqüències d’angiografia. Els descriptors emprats permeten caracteritzar la tinció miocàrdica amb una alta eficiència i fiabilitat. A més no hi ha diferències significatives en l’anàlisi de les seqüències obtingudes amb el pacient respirant amb normalitat o en apnea

Abstract: In this paper we introduce a novel application of the diffusion tensor for anisotropic image processing. The Anisotropic Contour Completion (ACC) we suggest consists in extending the characteristic function of the open curve by means of a degenerated diffusion tensor that prevents any diffusion in the normal direction. We show that ACC is equivalent to a dilation with a continuous elliptic structural element that takes into account the local orientation of the contours to be closed. Experiments on contours extracted from real images show that ACC produces shapes able to adapt to any curve in an active contour framework. 1.

Abstract: Deep understanding of myocardial structure of the heart would unravel crucial knowledge for clinical and medical procedures. The MIOCARDIA project is a multidisciplinary project in cooperation with l'Hospital de la Santa Creu i de Sant Pau, Clinica la Creu Blanca and Barcelona Supercomputing Center. The ultimate goal of this project is defining a computational model of the myocardium. The model takes into account the deep interrelation between the anatomy and the mechanics of the heart. The paper explains the workflow of the MIOCARDIA project. It also introduces a multiresolution reconstruction technique based on DT-MRI streamlining for simplified global myocardial model generation. Our reconstructions can restore the most complex myocardial structures and provides evidences of a global helical organization.