Abstract: This paper describes a method which uses the skull as a landmark for automatic registration of computer tomography to magnetic resonance (MR) images. First, the skull is extracted from both images using a new creaseness operator. Then, the resulting creaseness images are used to build a hierarchic structure which permits a robust and fast search. We have justified experimentally the performance of several choices of our algorithm, and we have thoroughly tested its accuracy and robustness against the well-known mutual information method for five different pairs of images. We have found both comparable, and for certain MR images the proposed method achieves better performance.

Abstract: Retinal images are routinely used in ophthalmology to study the optical nerve head and the retina. To assess objectively the evolution of an illness, images taken at different times must be registered. Most methods so far have been designed specifically for a single image modality, like temporal series or stereo pairs of angiographies, fluorescein angiographies or scanning laser ophthalmoscope (SLO) images, which makes them prone to fail when conditions vary. In contrast, the method we propose has shown to be accurate and reliable on all the former modalities. It has been adapted from the 3D registration of CT and MR image to 2D. Relevant features (also known as landmarks) are extracted by means of a robust creaseness operator, and resulting images are iteratively transformed until a maximum in their correlation is achieved. Our method has succeeded in more than 100 pairs tried so far, in all cases including also the scaling as a parameter to be optimized