Abstract: Intravascular ultrasound (IVUS) technology permits visualization of high-resolution images of internal vascular structures. IVUS is a unique image-guiding tool to display longitudinal view of the vessels, and estimate the length and size of vascular structures with the goal of accurate diagnosis. Unfortunately, due to pulsatile contraction and expansion of the heart, the captured images are affected by different motion artifacts that make visual inspection difficult. In this paper, we propose an efficient algorithm that aligns vascular structures and strongly reduces the saw-shaped oscillation, simplifying the inspection of longitudinal cuts; it reduces the motion artifacts caused by the displacement of the catheter in the short-axis plane and the catheter rotation due to vessel tortuosity. The algorithm prototype aligns 3.16 frames/s and clearly outperforms state-of-the-art methods with similar computational cost. The speed of the algorithm is crucial since it allows to inspect the corrected sequence during patient intervention. Moreover, we improved an indirect methodology for IVUS rigid registration algorithm evaluation.

Abstract: One of the most widely used assumptions in supervised learning is that data is independent and identically distributed. This assumption does not hold true in many real cases. Sequential learning is the discipline of machine learning that deals with dependent data such that neighboring examples exhibit some kind of relationship. In the literature, there are different approaches that try to capture and exploit this correlation, by means of different methodologies. In this paper we focus on meta-learning strategies and, in particular, the stacked sequential learning approach. The main contribution of this work is two-fold: first, we generalize the stacked sequential learning. This generalization reflects the key role of neighboring interactions modeling. Second, we propose an effective and efficient way of capturing and exploiting sequential correlations that takes into account long-range interactions by means of a multi-scale pyramidal decomposition of the predicted labels. Additionally, this new method subsumes the standard stacked sequential learning approach. We tested the proposed method on two different classification tasks: text lines classification in a FAQ data set and image classification. Results on these tasks clearly show that our approach outperforms the standard stacked sequential learning. Moreover, we show that the proposed method allows to control the trade-off between the detail and the desired range of the interactions.

Abstract: A common way to model multiclass classification problems is to design a set of binary classifiers and to combine them. Error-correcting output codes (ECOC) represent a successful framework to deal with these type of problems. Recent works in the ECOC framework showed significant performance improvements by means of new problem-dependent designs based on the ternary ECOC framework. The ternary framework contains a larger set of binary problems because of the use of a ldquodo not carerdquo symbol that allows us to ignore some classes by a given classifier. However, there are no proper studies that analyze the effect of the new symbol at the decoding step. In this paper, we present a taxonomy that embeds all binary and ternary ECOC decoding strategies into four groups. We show that the zero symbol introduces two kinds of biases that require redefinition of the decoding design. A new type of decoding measure is proposed, and two novel decoding strategies are defined. We evaluate the state-of-the-art coding and decoding strategies over a set of UCI machine learning repository data sets and into a real traffic sign categorization problem. The experimental results show that, following the new decoding strategies, the performance of the ECOC design is significantly improved.

Abstract: Accurate detection of in-vivo vulnerable plaque in coronary arteries is still an open problem. Recent studies show that it is highly related to tissue structure and composition. Intravascular Ultrasound (IVUS) is a powerful imaging technique that gives a detailed cross-sectional image of the vessel, allowing to explore arteries morphology. IVUS data validation is usually performed by comparing post-mortem (in-vitro) IVUS data and corresponding histological analysis of the tissue. The main drawback of this method is the few number of available case studies and validated data due to the complex procedure of histological analysis of the tissue. On the other hand, IVUS data from in-vivo cases is easy to obtain but it can not be histologically validated. In this work, we propose to enhance the in-vitro training data set by selectively including examples from in-vivo plaques. For this purpose, a Sequential Floating Forward Selection method is reformulated in the context of plaque characterization. The enhanced classifier performance is validated on in-vitro data set, yielding an overall accuracy of 91.59% in discriminating among fibrotic, lipidic and calcified plaques, while reducing the gap between in-vivo and in-vitro data analysis. Experimental results suggest that the obtained classifier could be properly applied on in-vivo plaque characterization and also demonstrate that the common hypothesis of assuming the difference between in-vivo and in-vitro as negligible is incorrect.

Abstract: A standard way to deal with multi-class categorization problems is by the combination of binary classifiers in a pairwise voting procedure. Recently, this classical approach has been formalized in the Error-Correcting Output Codes (ECOC) framework. In the ECOC framework, the one-versus-one coding demonstrates to achieve higher performance than the rest of coding designs. The binary problems that we train in the one-versus-one strategy are significantly smaller than in the rest of designs, and usually easier to be learnt, taking into account the smaller overlapping between classes. However, a high percentage of the positions coded by zero of the coding matrix, which implies a high sparseness degree, does not codify meta-class membership information. In this paper, we show that using the training data we can redefine without re-training, in a problem-dependent way, the one-versus-one coding matrix so that the new coded information helps the system to increase its generalization capability. Moreover, the new re-coding strategy is generalized to be applied over any binary code. The results over several UCI Machine Learning repository data sets and two real multi-class problems show that performance improvements can be obtained re-coding the classical one-versus-one and Sparse random designs compared to different state-of-the-art ECOC configurations.

Abstract: We present a meta-learning framework for the design of potential functions for Conditional Random Fields. The design of both node potential and edge potential is formulated as a classification problem where margin classifiers are used. The set of state transitions for the edge potential is treated as a set of different classes, thus defining a multi-class learning problem. The Error-Correcting Output Codes (ECOC) technique is used to deal with the multi-class problem. Furthermore, the point defined by the combination of margin classifiers in the ECOC space is interpreted in a probabilistic manner, and the obtained distance values are then converted into potential values. The proposed model exhibits very promising results when applied to two real detection problems.