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Guillermo Torres, Debora Gil, Antoni Rosell, S. Mena, & Carles Sanchez. (2023). Virtual Radiomics Biopsy for the Histological Diagnosis of Pulmonary Nodules. In 37th International Congress and Exhibition is organized by Computer Assisted Radiology and Surgery.
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Sonia Baeza, Debora Gil, Carles Sanchez, Guillermo Torres, Ignasi Garcia Olive, Ignasi Guasch, et al. (2023). Biopsia virtual radiomica para el diagnóstico histológico de nódulos pulmonares – Resultados intermedios del proyecto Radiolung. In SEPAR.
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Debora Gil, Guillermo Torres, & Carles Sanchez. (2023). Transforming radiomic features into radiological words. In IEEE International Symposium on Biomedical Imaging.
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Pau Cano, Debora Gil, & Eva Musulen. (2023). Towards automatic detection of helicobacter pylori in histological samples of gastric tissue. In IEEE International Symposium on Biomedical Imaging.
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Guillermo Torres, Debora Gil, Antonio Rosell, Sonia Baeza, & Carles Sanchez. (2023). A radiomic biopsy for virtual histology of pulmonary nodules. In IEEE International Symposium on Biomedical Imaging.
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Jose Elias Yauri. (2023). Deep Learning Based Data Fusion Approaches for the Assessment of Cognitive States on EEG Signals (Aura Hernandez, & Debora Gil, Eds.). Ph.D. thesis, IMPRIMA, .
Abstract: For millennia, the study of the couple brain-mind has fascinated the humanity in order to understand the complex nature of cognitive states. A cognitive state is the state of the mind at a specific time and involves cognition activities to acquire and process information for making a decision, solving a problem, or achieving a goal.
While normal cognitive states assist in the successful accomplishment of tasks; on the contrary, abnormal states of the mind can lead to task failures due to a reduced cognition capability. In this thesis, we focus on the assessment of cognitive states by means of the analysis of ElectroEncephaloGrams (EEG) signals using deep learning methods. EEG records the electrical activity of the brain using a set of electrodes placed on the scalp that output a set of spatiotemporal signals that are expected to be correlated to a specific mental process.
From the point of view of artificial intelligence, any method for the assessment of cognitive states using EEG signals as input should face several challenges. On the one hand, one should determine which is the most suitable approach for the optimal combination of the multiple signals recorded by EEG electrodes. On the other hand, one should have a protocol for the collection of good quality unambiguous annotated data, and an experimental design for the assessment of the generalization and transfer of models. In order to tackle them, first, we propose several convolutional neural architectures to perform data fusion of the signals recorded by EEG electrodes, at raw signal and feature levels. Four channel fusion methods, easy to incorporate into any neural network architecture, are proposed and assessed. Second, we present a method to create an unambiguous dataset for the prediction of cognitive mental workload using serious games and an Airbus-320 flight simulator. Third, we present a validation protocol that takes into account the levels of generalization of models based on the source and amount of test data.
Finally, the approaches for the assessment of cognitive states are applied to two use cases of high social impact: the assessment of mental workload for personalized support systems in the cockpit and the detection of epileptic seizures. The results obtained from the first use case show the feasibility of task transfer of models trained to detect workload in serious games to real flight scenarios. The results from the second use case show the generalization capability of our EEG channel fusion methods at k-fold cross-validation, patient-specific, and population levels.
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Albert Andaluz. (2009). LV Contour Segmentation in TMR images using Semantic Description of Tissue and Prior Knowledge Correction (Vol. 142). Master's thesis, , Bellaterra 08193, Barcelona, Spain.
Abstract: The Diagnosis of Left Ventricle (LV) pathologies is related to regional wall motion analysis. Health indicator scores such as the rotation and the torsion are useful for the diagnose of the Left Ventricle (LV) function. However, this requires proper identification of LV segments. On one hand, manual segmentation is robust, but it is slow and requires medical expertise. On the other hand, the tag pattern in Tagged Magnetic Resonance (TMR) sequences is a problem for the automatic segmentation of the LV boundaries. Consequently, we propose a method based in the classical formulation of parametric Snakes, combined with Active Shape models. Our semantic definition of the LV is tagged tissue that experiences motion in the systolic cycle. This defines two energy potentials for the Snake convergence. Additionally, the mean shape corrects excessive deviation from the anatomical shape. We have validated our approach in 15 healthy volunteers and two short axis cuts. In this way, we have compared the automatic segmentations to manual shapes outlined by medical experts. Also, we have explored the accuracy of clinical scores computed using automatic contours. The results show minor divergence in the approximation and the manual segmentations as well as robust computation of clinical scores in all cases. From this we conclude that the proposed method is a promising support tool for clinical analysis.
Keywords: Active Contour Models; Snakes; Active Shape Models; Deformable Templates; Left Ventricle Segmentation; Generalized Orthogonal Procrustes Analysis; Harmonic Phase Flow; Principal Component Analysis; Tagged Magnetic Resonance
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Debora Gil, Jaume Garcia, Mariano Vazquez, Ruth Aris, & Guilleaume Houzeaux. (2008). Patient-Sensitive Anatomic and Functional 3D Model of the Left Ventricle Function. In 8th World Congress on Computational Mechanichs (WCCM8).
Abstract: Early diagnosis and accurate treatment of Left Ventricle (LV) dysfunction significantly increases the patient survival. Impairment of LV contractility due to cardiovascular diseases is reflected in its motion patterns. Recent advances in medical imaging, such as Magnetic Resonance (MR), have encouraged research on 3D simulation and modelling of the LV dynamics. Most of the existing 3D models [1] consider just the gross anatomy of the LV and restore a truncated ellipse which deforms along the cardiac cycle. The contraction mechanics of any muscle strongly depends on the spatial orientation of its muscular fibers since the motion that the muscle undergoes mainly takes place along the fibers. It follows that such simplified models do not allow evaluation of the heart electro-mechanical function and coupling, which has recently risen as the key point for understanding the LV functionality [2]. In order to thoroughly understand the LV mechanics it is necessary to consider the complete anatomy of the LV given by the orientation of the myocardial fibres in 3D space as described by Torrent Guasp [3].
We propose developing a 3D patient-sensitive model of the LV integrating, for the first time, the ven- tricular band anatomy (fibers orientation), the LV gross anatomy and its functionality. Such model will represent the LV function as a natural consequence of its own ventricular band anatomy. This might be decisive in restoring a proper LV contraction in patients undergoing pace marker treatment.
The LV function is defined as soon as the propagation of the contractile electromechanical pulse has been modelled. In our experiments we have used the wave equation for the propagation of the electric pulse. The electromechanical wave moves on the myocardial surface and should have a conductivity tensor oriented along the muscular fibers. Thus, whatever mathematical model for electric pulse propa- gation [4] we consider, the complete anatomy of the LV should be extracted.
The LV gross anatomy is obtained by processing multi slice MR images recorded for each patient. Information about the myocardial fibers distribution can only be extracted by Diffusion Tensor Imag- ing (DTI), which can not provide in vivo information for each patient. As a first approach, we have
Figure 1: Scheme for the Left Ventricle Patient-Sensitive Model.
computed an average model of fibers from several DTI studies of canine hearts. This rough anatomy is the input for our electro-mechanical propagation model simulating LV dynamics. The average fiber orientation is updated until the simulated LV motion agrees with the experimental evidence provided by the LV motion observed in tagged MR (TMR) sequences. Experimental LV motion is recovered by applying image processing, differential geometry and interpolation techniques to 2D TMR slices [5]. The pipeline in figure 1 outlines the interaction between simulations and experimental data leading to our patient-tailored model.
Keywords: Left Ventricle, Electromechanical Models, Image Processing, Magnetic Resonance.
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Jaume Garcia, Debora Gil, Sandra Pujades, & Francesc Carreras. (2008). Valoracion de la Funcion del Ventriculo Izquierdo mediante Modelos Regionales Hiperparametricos. Revista Española de Cardiologia, 61(3), 79.
Abstract: La mayoría de la enfermedades cardiovasculares afectan a las propiedades contráctiles de la banda ventricular helicoidal. Esto se refleja en una variación del comportamiento normal de la función ventricular. Parámetros locales tales como los strains, o la deformación experimentada por el tejido, son indicadores capaces de detectar anomalías funcionales en territorios específicos. A menudo, dichos parámetros son considerados de forma separada. En este trabajo presentamos un marco computacional (el Dominio Paramétrico Normalizado, DPN) que permite integrarlos en hiperparámetros funcionales y estudiar sus rangos de normalidad. Dichos rangos permiten valorar de forma objetiva la función regional de cualquier nuevo paciente. Para ello, consideramos secuencias de resonancia magnética etiquetada a nivel basal, medio y apical. Los hiperparámetros se obtienen a partir del movimiento intramural del VI estimado mediante el método Harmonic Phase Flow. El DPN se define a partir de en una parametrización del Ventrículo Izquierdo (VI) en sus coordenadas radiales y circunferencial basada en criterios anatómicos. El paso de los hiperparámetros al DPN hace posible la comparación entre distintos pacientes. Los rangos de normalidad se definen mediante análisis estadístico de valores de voluntarios sanos en 45 regiones del DPN a lo largo de 9 fases sistólicas. Se ha usado un conjunto de 19 (14 H; E: 30.7±7.5) voluntarios sanos para crear los patrones de normalidad y se han validado usando 2 controles sanos y 3 pacientes afectados de contractilidad global reducida. Para los controles los resultados regionales se han ajustado dentro de la normalidad, mientras que para los pacientes se han obtenido valores anormales en las zonas descritas, localizando y cuantificando así el diagnóstico empírico.
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C. Santa-Marta, Jaume Garcia, A. Bajo, J.J. Vaquero, M. Ledesma-Carbayo, & Debora Gil. (2008). Influence of the Temporal Resolution on the Quantification of Displacement Fields in Cardiac Magnetic Resonance Tagged Images. In S. A. Roberto hornero (Ed.), XXVI Congreso Anual de la Sociedad Española de Ingenieria Biomedica (352–353).
Abstract: It is difficult to acquire tagged cardiac MR images with a high temporal and spatial resolution using clinical MR scanners. However, if such images are used for quantifying scores based on motion, it is essential a resolution as high as possibl e. This paper explores the influence of the temporal resolution of a tagged series on the quantification of myocardial dynamic parameters. To such purpose we have designed a SPAMM (Spatial Modulation of Magnetization) sequence allowing acquisition of sequences at simple and double temporal resolution. Sequences are processed to compute myocardial motion by an automatic technique based on the tracking of the harmonic phase of tagged images (the Harmonic Phase Flow, HPF). The results have been compared to manual tracking of myocardial tags. The error in displacement fields for double resolution sequences reduces 17%.
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Francesc Carreras, Jaume Garcia, Debora Gil, Sandra Pujadas, Chi ho Lion, R.Suarez-Arias, et al. (2012). Left ventricular torsion and longitudinal shortening: two fundamental components of myocardial mechanics assessed by tagged cine-MRI in normal subjects. IJCI - International Journal of Cardiovascular Imaging, 28(2), 273–284.
Abstract: Cardiac magnetic resonance imaging (Cardiac MRI) has become a gold standard diagnostic technique for the assessment of cardiac mechanics, allowing the non-invasive calculation of left ventric- ular long axis longitudinal shortening (LVLS) and absolute myocardial torsion (AMT) between basal and apical left ventricular slices, a movement directly related to the helicoidal anatomic disposition of the myocardial fibers. The aim of this study is to determine AMT and LVLS behaviour and normal values from a group of healthy subjects. A group of 21 healthy volunteers (15 males) (age: 23–55 y.o., mean:30.7 ± 7.5) were prospectively included in an obser- vational study by Cardiac MRI. Left ventricular rotation (degrees) was calculated by custom-made software (Harmonic Phase Flow) in consecutive LV short axis planes tagged cine-MRI sequences. AMT was determined from the difference between basal and apical planes LV rotations. LVLS (%) was determined from the LV longitudinal and horizontal axis cine-MRI images. All the 21 cases studied were interpretable, although in three cases the value of the LV apical rotation could not be determined. The mean rotation of the basal and apical planes at end-systole were -3.71° ± 0.84° and 6.73° ± 1.69° (n:18) respectively, resulting in a LV mean AMT of 10.48° ± 1.63° (n:18). End-systolic mean LVLS was 19.07 ± 2.71%. Cardiac MRI allows for the calculation of AMT and LVLS, fundamental functional components of the ventricular twist mechanics conditioned, in turn, by the anatomical helical layout of the myocardial fibers. These values provide complementary information about systolic ventricular function in relation to the traditional parameters used in daily practice.
Keywords: Magnetic resonance imaging (MRI); Tagging MRI; Cardiac mechanics; Ventricular torsion
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Jaume Garcia, Debora Gil, Francesc Carreras, Sandra Pujades, R.Leta, Xavier Alomar, et al. (2008). Patrons de Normalitat Regional per la Valoració de la Funció del Ventricle Esquerre. In XX Congrés de la Societat Catalana de Cardiologia (60). Barcelona.
Abstract: Les malalties cardiovasculars afecten les propietats contràctils de la banda ventricular i provoquen una variació de la funció del Ventricle Esquerre (VE) . Només els indicadors locals (strains, la deformació del teixit) són capaços de detectar anomalies en territoris específics del VE . Patrons de normalitat regionals d’aquests paràmetres serien d’utilitat a l’hora de valorar-ne la funció .
Presentem un Domini Paramètric Normalitzat (DPN) que permet comparar dades de diferents pacients i definir Patrons de Normalitat Regional (PNR)
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Jaume Garcia. (2004). Generalized Active Shape Models Applied to Cardiac Function Analysis. Master's thesis, , .
Abstract: Medical imaging is very useful in the assessment and treatment of many diseases. To deal with the great amount of data provided by imaging scanners and extract quantitative information that physicians can interpret, many analysis algorithms have been developed. Any process of analysis always consists of a first step of segmenting some particular structure. In medical imaging, structures are not always well defined and suffer from noise artifacts thus, ordinary segmentation methods are not well suited. The ones that seem to give better results are those based on deformable models. Nevertheless, despite their capability of mixing image features together with smoothness constraints that may compensate for image irregularities, these are naturally local methods, i. e., each node of the active contour evolve taking into account information about its neighbors and some other weak constraints about flexibility and smoothness, but not about the global shape that they should find. Due to the fact that structures to be segmented are the same for all cases but with some inter and intra-patient variation, the incorporation of a priori knowledge about shape in the segmentation method will provide robustness to it. Active Shape Models is an algorithm based on the creation of a shape model called Point Distribution Model. It performs a segmentation using only shapes similar than those previously learned from a training set that capture most of the variation presented by the structure. This algorithm works by updating shape nodes along a normal segment which often can be too restrictive. For this reason we propose a generalization of this algorithm that we call Generalized Active Shape Models and fully integrates the a priori knowledge given by the Point Distribution Model with deformable models or any other appropriate segmentation method. Two different applications to cardiac imaging of this generalized method are developed and promising results are shown.
Keywords: Cardiac Analysis; Deformable Models; Active Contour Models; Active Shape Models; Tagged MRI; HARP; Contrast Echocardiography.
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Debora Gil. (2004). Geometric Differential Operators for Shape Modelling (Jordi Saludes i Closa, & Petia Radeva, Eds.). Ph.D. thesis, Ediciones Graficas Rey, Barcelona (Spain).
Abstract: Medical imaging feeds research in many computer vision and image processing fields: image filtering, segmentation, shape recovery, registration, retrieval and pattern matching. Because of their low contrast changes and large variety of artifacts and noise, medical imaging processing techniques relying on an analysis of the geometry of image level sets rather than on intensity values result in more robust treatment. From the starting point of treatment of intravascular images, this PhD thesis ad- dresses the design of differential image operators based on geometric principles for a robust shape modelling and restoration. Among all fields applying shape recovery, we approach filtering and segmentation of image objects. For a successful use in real images, the segmentation process should go through three stages: noise removing, shape modelling and shape recovery. This PhD addresses all three topics, but for the sake of algorithms as automated as possible, techniques for image processing will be designed to satisfy three main principles: a) convergence of the iterative schemes to non-trivial states avoiding image degeneration to a constant image and representing smooth models of the originals; b) smooth asymptotic behav- ior ensuring stabilization of the iterative process; c) fixed parameter values ensuring equal (domain free) performance of the algorithms whatever initial images/shapes. Our geometric approach to the generic equations that model the different processes approached enables defining techniques satisfying all the former requirements. First, we introduce a new curvature-based geometric flow for image filtering achieving a good compromise between noise removing and resemblance to original images. Sec- ond, we describe a new family of diffusion operators that restrict their scope to image level curves and serve to restore smooth closed models from unconnected sets of points. Finally, we design a regularization of snake (distance) maps that ensures its smooth convergence towards any closed shape. Experiments show that performance of the techniques proposed overpasses that of state-of-the-art algorithms.
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Debora Gil. (2002). Regularized Curvature Flow. Computer Vision Centre.
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