Francisco Javier Orozco, Xavier Roca, & Jordi Gonzalez. (2008). Real-Time Gaze Tracking with Appearance-Based Models. MVAP - Machine Vision Applications, 20(6), 353–364.
Abstract: Psychological evidence has emphasized the importance of eye gaze analysis in human computer interaction and emotion interpretation. To this end, current image analysis algorithms take into consideration eye-lid and iris motion detection using colour information and edge detectors. However, eye movement is fast and and hence difficult to use to obtain a precise and robust tracking. Instead, our
method proposed to describe eyelid and iris movements as continuous variables using appearance-based tracking. This approach combines the strengths of adaptive appearance models, optimization methods and backtracking techniques.Thus,
in the proposed method textures are learned on-line from near frontal images and illumination changes, occlusions and fast movements are managed. The method achieves real-time performance by combining two appearance-based trackers to a
backtracking algorithm for eyelid estimation and another for iris estimation. These contributions represent a significant advance towards a reliable gaze motion description for HCI and expression analysis, where the strength of complementary
methodologies are combined to avoid using high quality images, colour information, texture training, camera settings and other time-consuming processes.
Keywords: Keywords Eyelid and iris tracking, Appearance models, Blinking, Iris saccade, Real-time gaze tracking
|
Jaume Garcia, Debora Gil, Sandra Pujades, & Francesc Carreras. (2008). A Variational Framework for Assessment of the Left Ventricle Motion. International Journal Mathematical Modelling of Natural Phenomena, 3(6), 76–100.
Abstract: Impairment of left ventricular contractility due to cardiovascular diseases is reflected in left ventricle (LV) motion patterns. An abnormal change of torsion or long axis shortening LV values can help with the diagnosis and follow-up of LV dysfunction. Tagged Magnetic Resonance (TMR) is a widely spread medical imaging modality that allows estimation of the myocardial tissue local deformation. In this work, we introduce a novel variational framework for extracting the left ventricle dynamics from TMR sequences. A bi-dimensional representation space of TMR images given by Gabor filter banks is defined. Tracking of the phases of the Gabor response is combined using a variational framework which regularizes the deformation field just at areas where the Gabor amplitude drops, while restoring the underlying motion otherwise. The clinical applicability of the proposed method is illustrated by extracting normality models of the ventricular torsion from 19 healthy subjects.
Keywords: Key words: Left Ventricle Dynamics, Ventricular Torsion, Tagged Magnetic Resonance, Motion Tracking, Variational Framework, Gabor Transform.
|
David Roche, Debora Gil, & Jesus Giraldo. (2014). Mathematical modeling of G protein-coupled receptor function: What can we learn from empirical and mechanistic models? In G Protein-Coupled Receptors – Modeling and Simulation Advances in Experimental Medicine and Biology (Vol. 796, pp. 159–181). Springer Netherlands.
Abstract: Empirical and mechanistic models differ in their approaches to the analysis of pharmacological effect. Whereas the parameters of the former are not physical constants those of the latter embody the nature, often complex, of biology. Empirical models are exclusively used for curve fitting, merely to characterize the shape of the E/[A] curves. Mechanistic models, on the contrary, enable the examination of mechanistic hypotheses by parameter simulation. Regretfully, the many parameters that mechanistic models may include can represent a great difficulty for curve fitting, representing, thus, a challenge for computational method development. In the present study some empirical and mechanistic models are shown and the connections, which may appear in a number of cases between them, are analyzed from the curves they yield. It may be concluded that systematic and careful curve shape analysis can be extremely useful for the understanding of receptor function, ligand classification and drug discovery, thus providing a common language for the communication between pharmacologists and medicinal chemists.
Keywords: β-arrestin; biased agonism; curve fitting; empirical modeling; evolutionary algorithm; functional selectivity; G protein; GPCR; Hill coefficient; intrinsic efficacy; inverse agonism; mathematical modeling; mechanistic modeling; operational model; parameter optimization; receptor dimer; receptor oligomerization; receptor constitutive activity; signal transduction; two-state model
|
Simone Balocco, Francesco Ciompi, Juan Rigla, Xavier Carrillo, Josefina Mauri, & Petia Radeva. (2019). Assessment of intracoronary stent location and extension in intravascular ultrasound sequences. MEDPHYS - Medical Physics, 46(2), 484–493.
Abstract: PURPOSE:
An intraluminal coronary stent is a metal scaffold deployed in a stenotic artery during percutaneous coronary intervention (PCI). In order to have an effective deployment, a stent should be optimally placed with regard to anatomical structures such as bifurcations and stenoses. Intravascular ultrasound (IVUS) is a catheter-based imaging technique generally used for PCI guiding and assessing the correct placement of the stent. A novel approach that automatically detects the boundaries and the position of the stent along the IVUS pullback is presented. Such a technique aims at optimizing the stent deployment.
METHODS:
The method requires the identification of the stable frames of the sequence and the reliable detection of stent struts. Using these data, a measure of likelihood for a frame to contain a stent is computed. Then, a robust binary representation of the presence of the stent in the pullback is obtained applying an iterative and multiscale quantization of the signal to symbols using the Symbolic Aggregate approXimation algorithm.
RESULTS:
The technique was extensively validated on a set of 103 IVUS of sequences of in vivo coronary arteries containing metallic and bioabsorbable stents acquired through an international multicentric collaboration across five clinical centers. The method was able to detect the stent position with an overall F-measure of 86.4%, a Jaccard index score of 75% and a mean distance of 2.5 mm from manually annotated stent boundaries, and in bioabsorbable stents with an overall F-measure of 88.6%, a Jaccard score of 77.7 and a mean distance of 1.5 mm from manually annotated stent boundaries. Additionally, a map indicating the distance between the lumen and the stent along the pullback is created in order to show the angular sectors of the sequence in which the malapposition is present.
CONCLUSIONS:
Results obtained comparing the automatic results vs the manual annotation of two observers shows that the method approaches the interobserver variability. Similar performances are obtained on both metallic and bioabsorbable stents, showing the flexibility and robustness of the method.
Keywords: IVUS; malapposition; stent; ultrasound
|
Simone Balocco, Carlo Gatta, Francesco Ciompi, A. Wahle, Petia Radeva, S. Carlier, et al. (2014). Standardized evaluation methodology and reference database for evaluating IVUS image segmentation. CMIG - Computerized Medical Imaging and Graphics, 38(2), 70–90.
Abstract: This paper describes an evaluation framework that allows a standardized and quantitative comparison of IVUS lumen and media segmentation algorithms. This framework has been introduced at the MICCAI 2011 Computing and Visualization for (Intra)Vascular Imaging (CVII) workshop, comparing the results of eight teams that participated.
We describe the available data-base comprising of multi-center, multi-vendor and multi-frequency IVUS datasets, their acquisition, the creation of the reference standard and the evaluation measures. The approaches address segmentation of the lumen, the media, or both borders; semi- or fully-automatic operation; and 2-D vs. 3-D methodology. Three performance measures for quantitative analysis have
been proposed. The results of the evaluation indicate that segmentation of the vessel lumen and media is possible with an accuracy that is comparable to manual annotation when semi-automatic methods are used, as well as encouraging results can be obtained also in case of fully-automatic segmentation. The analysis performed in this paper also highlights the challenges in IVUS segmentation that remains to be
solved.
Keywords: IVUS (intravascular ultrasound); Evaluation framework; Algorithm comparison; Image segmentation
|
Miguel Oliveira, Victor Santos, & Angel Sappa. (2015). Multimodal Inverse Perspective Mapping. IF - Information Fusion, 24, 108–121.
Abstract: Over the past years, inverse perspective mapping has been successfully applied to several problems in the field of Intelligent Transportation Systems. In brief, the method consists of mapping images to a new coordinate system where perspective effects are removed. The removal of perspective associated effects facilitates road and obstacle detection and also assists in free space estimation. There is, however, a significant limitation in the inverse perspective mapping: the presence of obstacles on the road disrupts the effectiveness of the mapping. The current paper proposes a robust solution based on the use of multimodal sensor fusion. Data from a laser range finder is fused with images from the cameras, so that the mapping is not computed in the regions where obstacles are present. As shown in the results, this considerably improves the effectiveness of the algorithm and reduces computation time when compared with the classical inverse perspective mapping. Furthermore, the proposed approach is also able to cope with several cameras with different lenses or image resolutions, as well as dynamic viewpoints.
Keywords: Inverse perspective mapping; Multimodal sensor fusion; Intelligent vehicles
|
Marina Alberti, Simone Balocco, Xavier Carrillo, Josefina Mauri, & Petia Radeva. (2013). Automatic non-rigid temporal alignment of IVUS sequences: method and quantitative validation. UMB - Ultrasound in Medicine and Biology, 39(9), 1698–712.
Abstract: Clinical studies on atherosclerosis regression/progression performed by intravascular ultrasound analysis would benefit from accurate alignment of sequences of the same patient before and after clinical interventions and at follow-up. In this article, a methodology for automatic alignment of intravascular ultrasound sequences based on the dynamic time warping technique is proposed. The non-rigid alignment is adapted to the specific task by applying it to multidimensional signals describing the morphologic content of the vessel. Moreover, dynamic time warping is embedded into a framework comprising a strategy to address partial overlapping between acquisitions and a term that regularizes non-physiologic temporal compression/expansion of the sequences. Extensive validation is performed on both synthetic and in vivo data. The proposed method reaches alignment errors of approximately 0.43 mm for pairs of sequences acquired during the same intervention phase and 0.77 mm for pairs of sequences acquired at successive intervention stages.
Keywords: Intravascular ultrasound; Dynamic time warping; Non-rigid alignment; Sequence matching; Partial overlapping strategy
|
Simone Balocco, Mauricio Gonzalez, Ricardo Ñancule, Petia Radeva, & Gabriel Thomas. (2018). Calcified Plaque Detection in IVUS Sequences: Preliminary Results Using Convolutional Nets. In International Workshop on Artificial Intelligence and Pattern Recognition (Vol. 11047, pp. 34–42). LNCS.
Abstract: The manual inspection of intravascular ultrasound (IVUS) images to detect clinically relevant patterns is a difficult and laborious task performed routinely by physicians. In this paper, we present a framework based on convolutional nets for the quick selection of IVUS frames containing arterial calcification, a pattern whose detection plays a vital role in the diagnosis of atherosclerosis. Preliminary experiments on a dataset acquired from eighty patients show that convolutional architectures improve detections of a shallow classifier in terms of 𝐹1-measure, precision and recall.
Keywords: Intravascular ultrasound images; Convolutional nets; Deep learning; Medical image analysis
|
Misael Rosales, Petia Radeva, Oriol Rodriguez-Leon, & Debora Gil. (2009). Modelling of image-catheter motion for 3-D IVUS. MIA - Medical image analysis, 13(1), 91–104.
Abstract: Three-dimensional intravascular ultrasound (IVUS) allows to visualize and obtain volumetric measurements of coronary lesions through an exploration of the cross sections and longitudinal views of arteries. However, the visualization and subsequent morpho-geometric measurements in IVUS longitudinal cuts are subject to distortion caused by periodic image/vessel motion around the IVUS catheter. Usually, to overcome the image motion artifact ECG-gating and image-gated approaches are proposed, leading to slowing the pullback acquisition or disregarding part of IVUS data. In this paper, we argue that the image motion is due to 3-D vessel geometry as well as cardiac dynamics, and propose a dynamic model based on the tracking of an elliptical vessel approximation to recover the rigid transformation and align IVUS images without loosing any IVUS data. We report an extensive validation with synthetic simulated data and in vivo IVUS sequences of 30 patients achieving an average reduction of the image artifact of 97% in synthetic data and 79% in real-data. Our study shows that IVUS alignment improves longitudinal analysis of the IVUS data and is a necessary step towards accurate reconstruction and volumetric measurements of 3-D IVUS.
Keywords: Intravascular ultrasound (IVUS); Motion estimation; Motion decomposition; Fourier
|
Fernando Vilariño, Panagiota Spyridonos, Jordi Vitria, Fernando Azpiroz, & Petia Radeva. (2006). Cascade analysis for intestinal contraction detection. In 20th International Congress and exhibition Computer Assisted Radiology and Surgery (pp. 9–10).
Abstract: In this work, we address the study of intestinal contractions in a novel approach based on a machine learning framework to process data from Wireless Capsule Video Endoscopy. Wireless endoscopy represents a unique way to visualize the intestine motility by creating long videos to visualize intestine dynamics. In this paper we argue that to analyze huge amount of wireless endoscopy data and define robust methods for contraction detection we should base our approach on sophisticated machine learning techniques. In particular, we propose a cascade of classifiers in order to remove different physiological phenomenon and obtain the motility pattern of small intestines. Our results show obtaining high specificity and sensitivity rates that highlight the high efficiency of the selected approach and support the feasibility of the proposed methodology in the automatic detection and analysis of intestine contractions.
Keywords: intestine video analysis, anisotropic features, support vector machine, cascade of classifiers
|
Tadashi Araki, Sumit K. Banchhor, Narendra D. Londhe, Nobutaka Ikeda, Petia Radeva, Devarshi Shukla, et al. (2016). Reliable and Accurate Calcium Volume Measurement in Coronary Artery Using Intravascular Ultrasound Videos. JMS - Journal of Medical Systems, 40(3), 51:1–51:20.
Abstract: Quantitative assessment of calcified atherosclerotic volume within the coronary artery wall is vital for cardiac interventional procedures. The goal of this study is to automatically measure the calcium volume, given the borders of coronary vessel wall for all the frames of the intravascular ultrasound (IVUS) video. Three soft computing fuzzy classification techniques were adapted namely Fuzzy c-Means (FCM), K-means, and Hidden Markov Random Field (HMRF) for automated segmentation of calcium regions and volume computation. These methods were benchmarked against previously developed threshold-based method. IVUS image data sets (around 30,600 IVUS frames) from 15 patients were collected using 40 MHz IVUS catheter (Atlantis® SR Pro, Boston Scientific®, pullback speed of 0.5 mm/s). Calcium mean volume for FCM, K-means, HMRF and threshold-based method were 37.84 ± 17.38 mm3, 27.79 ± 10.94 mm3, 46.44 ± 19.13 mm3 and 35.92 ± 16.44 mm3 respectively. Cross-correlation, Jaccard Index and Dice Similarity were highest between FCM and threshold-based method: 0.99, 0.92 ± 0.02 and 0.95 + 0.02 respectively. Student’s t-test, z-test and Wilcoxon-test are also performed to demonstrate consistency, reliability and accuracy of the results. Given the vessel wall region, the system reliably and automatically measures the calcium volume in IVUS videos. Further, we validated our system against a trained expert using scoring: K-means showed the best performance with an accuracy of 92.80 %. Out procedure and protocol is along the line with method previously published clinically.
Keywords: Interventional cardiology; Atherosclerosis; Coronary arteries; IVUS; calcium volume; Soft computing; Performance Reliability; Accuracy
|
Jorge Bernal, F. Javier Sanchez, Cristina Rodriguez de Miguel, & Gloria Fernandez Esparrach. (2015). Bulding up the future of colonoscopy: A synergy between clinicians and computer scientists. In Colonoscopy and Colorectal Cancer.
Abstract: Recent advances in endoscopic technology have generated an increasing interest in strengthening the collaboration between clinicians and computers scientist to develop intelligent systems that can provide additional information to clinicians in the different stages of an intervention. The objective of this chapter is to identify clinical drawbacks of colonoscopy in order to define potential areas of collaboration. Once areas are defined, we present the challenges that colonoscopy images present in order computational methods to provide with meaningful output, including those related to image formation and acquisition, as they are proven to have an impact in the performance of an intelligent system. Finally, we also propose how to define validation frameworks in order to assess the performance of a given method, making an special emphasis on how databases should be created and annotated and which metrics should be used to evaluate systems correctly.
Keywords: Intelligent systems; Image properties; Validation; Clinical drawbacks; Endoluminal scene description
|
Antonio Lopez, J. Hilgenstock, A. Busse, Ramon Baldrich, Felipe Lumbreras, & Joan Serrat. (2008). Nightime Vehicle Detecion for Intelligent Headlight Control. In Advanced Concepts for Intelligent Vision Systems, 10th International Conference, Proceedings, (Vol. 5259, 113–124). LNCS.
Keywords: Intelligent Headlights; vehicle detection
|
Antonio Lopez, J. Hilgenstock, A. Busse, Ramon Baldrich, Felipe Lumbreras, & Joan Serrat. (2008). Temporal Coherence Analysis for Intelligent Headlight Control.
Keywords: Intelligent Headlights
|
Jose Carlos Rubio, Joan Serrat, Antonio Lopez, & Daniel Ponsa. (2010). Multiple-target tracking for the intelligent headlights control. In 13th Annual International Conference on Intelligent Transportation Systems (903–910).
Abstract: TA7.4
Intelligent vehicle lighting systems aim at automatically regulating the headlights' beam to illuminate as much of the road ahead as possible while avoiding dazzling other drivers. A key component of such a system is computer vision software that is able to distinguish blobs due to vehicles' headlights and rear lights from those due to road lamps and reflective elements such as poles and traffic signs. In a previous work, we have devised a set of specialized supervised classifiers to make such decisions based on blob features related to its intensity and shape. Despite the overall good performance, there remain challenging that have yet to be solved: notably, faint and tiny blobs corresponding to quite distant vehicles. In fact, for such distant blobs, classification decisions can be taken after observing them during a few frames. Hence, incorporating tracking could improve the overall lighting system performance by enforcing the temporal consistency of the classifier decision. Accordingly, this paper focuses on the problem of constructing blob tracks, which is actually one of multiple-target tracking (MTT), but under two special conditions: We have to deal with frequent occlusions, as well as blob splits and merges. We approach it in a novel way by formulating the problem as a maximum a posteriori inference on a Markov random field. The qualitative (in video form) and quantitative evaluation of our new MTT method shows good tracking results. In addition, we will also see that the classification performance of the problematic blobs improves due to the proposed MTT algorithm.
Keywords: Intelligent Headlights
|
