Abstract: Empirical and mechanistic models differ in their approaches to the analysis of pharmacological effect. Whereas the parameters of the former are not physical constants those of the latter embody the nature, often complex, of biology. Empirical models are exclusively used for curve fitting, merely to characterize the shape of the E/[A] curves. Mechanistic models, on the contrary, enable the examination of mechanistic hypotheses by parameter simulation. Regretfully, the many parameters that mechanistic models may include can represent a great difficulty for curve fitting, representing, thus, a challenge for computational method development. In the present study some empirical and mechanistic models are shown and the connections, which may appear in a number of cases between them, are analyzed from the curves they yield. It may be concluded that systematic and careful curve shape analysis can be extremely useful for the understanding of receptor function, ligand classification and drug discovery, thus providing a common language for the communication between pharmacologists and medicinal chemists.

Abstract: The increasing ubiquitousness of digital information in our daily lives has positioned video as a favored information vehicle, and given rise to an astonishing generation of social media and surveillance footage. This raises a series of technological demands for automatic video understanding and management, which together with the compromising attentional limitations of human operators, have motivated the research community to guide its steps towards a better attainment of such capabilities. As a result, current trends on cognitive vision promise to recognize complex events and self-adapt to different environments, while managing and integrating several types of knowledge. Future directions suggest to reinforce the multi-modal fusion of information sources and the communication with end-users.

Abstract: En este artículo presentamos los resultados de un experimento de categorización de color en el que las muestras se presentaron sobre un fondo multicolor (Mondrian) para simular los efectos del contexto. Los resultados se comparan con los de un experimento previo que, utilizando un paradigma diferente, determinó las fronteras sin tener en cuenta el contexto. El análisis de los resultados muestra que las fronteras obtenidas con el experimento en contexto presentan menos confusión que las obtenidas en el experimento sin contexto.

Abstract: Humansmove their eyes in order to learn visual representations of the world. These eye movements depend on distinct factors, either by the scene that we perceive or by our own decisions. To select what is relevant to attend is part of our survival mechanisms and the way we build reality, as we constantly react both consciously and unconsciously to all the stimuli that is projected into our eyes. In this thesis we try to explain (1) how we move our eyes, (2) how to build machines that understand visual information and deploy eyemovements, and (3) how to make these machines understand tasks in order to decide for eye movements.
(1) We provided the analysis of eye movement behavior elicited by low-level feature distinctiveness with a dataset of 230 synthetically-generated image patterns. A total of 15 types of stimuli has been generated (e.g. orientation, brightness, color, size, etc.), with 7 feature contrasts for each feature category. Eye-tracking data was collected from 34 participants during the viewing of the dataset, using Free-Viewing and Visual Search task instructions. Results showed that saliency is predominantly and distinctively influenced by: 1. feature type, 2. feature contrast, 3. Temporality of fixations, 4. task difficulty and 5. center bias. From such dataset (SID4VAM), we have computed a benchmark of saliency models by testing performance using psychophysical patterns. Model performance has been evaluated considering model inspiration and consistency with human psychophysics. Our study reveals that state-of-the-art Deep Learning saliency models do not performwell with synthetic pattern images, instead, modelswith Spectral/Fourier inspiration outperform others in saliency metrics and are more consistent with human psychophysical experimentation.
(2) Computations in the primary visual cortex (area V1 or striate cortex) have long been hypothesized to be responsible, among several visual processing mechanisms, of bottom-up visual attention (also named saliency). In order to validate this hypothesis, images from eye tracking datasets have been processed with a biologically plausible model of V1 (named Neurodynamic SaliencyWaveletModel or NSWAM). Following Li’s neurodynamic model, we define V1’s lateral connections with a network of firing rate neurons, sensitive to visual features such as brightness, color, orientation and scale. Early subcortical processes (i.e. retinal and thalamic) are functionally simulated. The resulting saliency maps are generated from the model output, representing the neuronal activity of V1 projections towards brain areas involved in eye movement control. We want to pinpoint that our unified computational architecture is able to reproduce several visual processes (i.e. brightness, chromatic induction and visual discomfort) without applying any type of training or optimization and keeping the same parametrization. The model has been extended (NSWAM-CM) with an implementation of the cortical magnification function to define the retinotopical projections towards V1, processing neuronal activity for each distinct view during scene observation. Novel computational definitions of top-down inhibition (in terms of inhibition of return and selection mechanisms), are also proposed to predict attention in Free-Viewing and Visual Search conditions. Results show that our model outperforms other biologically-inpired models of saliency prediction as well as to predict visual saccade sequences, specifically for nature and synthetic images. We also show how temporal and spatial characteristics of inhibition of return can improve prediction of saccades, as well as how distinct search strategies (in terms of feature-selective or category-specific inhibition) predict attention at distinct image contexts.
(3) Although previous scanpath models have been able to efficiently predict saccades during Free-Viewing, it is well known that stimulus and task instructions can strongly affect eye movement patterns. In particular, task priming has been shown to be crucial to the deployment of eye movements, involving interactions between brain areas related to goal-directed behavior, working and long-termmemory in combination with stimulus-driven eyemovement neuronal correlates. In our latest study we proposed an extension of the Selective Tuning Attentive Reference Fixation ControllerModel based on task demands (STAR-FCT), describing novel computational definitions of Long-TermMemory, Visual Task Executive and Task Working Memory. With these modules we are able to use textual instructions in order to guide the model to attend to specific categories of objects and/or places in the scene. We have designed our memorymodel by processing a visual hierarchy of low- and high-level features. The relationship between the executive task instructions and the memory representations has been specified using a tree of semantic similarities between the learned features and the object category labels. Results reveal that by using this model, the resulting object localizationmaps and predicted saccades have a higher probability to fall inside the salient regions depending on the distinct task instructions compared to saliency.

Abstract: Anticipating the intentions of vulnerable road users (VRUs) such as pedestrians
and cyclists can be critical for performing safe and comfortable driving maneuvers. This is the case for human driving and, therefore, should be taken into account by systems providing any level of driving assistance, i.e. from advanced driver assistant systems (ADAS) to fully autonomous vehicles (AVs). In this PhD work, we show how the latest advances on monocular vision-based human pose estimation, i.e. those relying on deep Convolutional Neural Networks (CNNs), enable to recognize the intentions of such VRUs. In the case of cyclists, we assume that they follow the established traffic codes to indicate future left/right turns and stop maneuvers with arm signals. In the case of pedestrians, no indications can be assumed a priori. Instead, we hypothesize that the walking pattern of a pedestrian can allow us to determine if he/she has the intention of crossing the road in the path of the egovehicle, so that the ego-vehicle must maneuver accordingly (e.g. slowing down or stopping). In this PhD work, we show how the same methodology can be used for recognizing pedestrians and cyclists’ intentions. For pedestrians, we perform experiments on the publicly available Daimler and JAAD datasets. For cyclists, we did not found an analogous dataset, therefore, we created our own one by acquiring
and annotating corresponding video-sequences which we aim to share with the
research community. Overall, the proposed pipeline provides new state-of-the-art results on the intention recognition of VRUs.

Abstract: Fine-grained recognition, i.e. identifying similar subcategories of the same superclass, is central to human activity. Recognizing a friend, finding bacteria in microscopic imagery, or discovering a new kind of galaxy, are just but few examples. However, fine-grained image recognition is still a challenging computer vision task since the differences between two images of the same category can overwhelm the differences between two images of different fine-grained categories. In this regime, where the difference between two categories resides on subtle input changes, excessively invariant CNNs discard those details that help to discriminate between categories and focus on more obvious changes, yielding poor classification performance.
On the other hand, CNNs with too much capacity tend to memorize instance-specific details, thus causing overfitting. In this thesis,motivated by the
potential impact of automatic fine-grained image recognition, we tackle the previous challenges and demonstrate that proper alignment of the inputs, multiple levels of attention, regularization, and explicitmodeling of the output space, results inmore accurate fine-grained recognitionmodels, that generalize better, and are more robust to intra-class variation. Concretely, we study the different stages of the neural network pipeline: input pre-processing, attention to regions, feature activations, and the label space. In each stage, we address different issues that hinder the recognition performance on various fine-grained tasks, and devise solutions in each chapter: i)We deal with the sensitivity to input alignment on fine-grained human facial motion such as pain. ii) We introduce an attention mechanism to allow CNNs to choose and process in detail the most discriminate regions of the image. iii)We further extend attention mechanisms to act on the network activations,
thus allowing them to correct their predictions by looking back at certain
regions, at different levels of abstraction. iv) We propose a regularization loss to prevent high-capacity neural networks to memorize instance details by means of almost-identical feature detectors. v)We finally study the advantages of explicitly modeling the output space within the error-correcting framework. As a result, in this thesis we demonstrate that attention and regularization seem promising directions to overcome the problems of fine-grained image recognition, as well as proper treatment of the input and the output space.

Abstract: Text understanding in scene images has gained plenty of attention in the computer vision community and it is an important task in many applications as text carries semantically rich information about scene content and context. For instance, reading text in a scene can be applied to autonomous driving, scene understanding or assisting visually impaired people. The general aim of scene text understanding is to localize and recognize text in scene images. Text regions are first localized in the original image by a trained detector model and afterwards fed into a recognition module. The tasks of localization and recognition are highly correlated since an inaccurate localization can affect the recognition task.
The main purpose of this thesis is to devise efficient methods for scene text understanding. We investigate how the latest results on deep learning can advance text understanding pipelines. Recently, Fully Convolutional Networks (FCNs) and derived methods have achieved a significant performance on semantic segmentation and pixel level classification tasks. Therefore, we took benefit of the strengths of FCN approaches in order to detect text in natural scenes. In this thesis we have focused on two challenging tasks of scene text understanding which are Text Detection and Word Spotting. For the task of text detection, we have proposed an efficient text proposal technique in scene images. We have considered the Text Proposals method as the baseline which is an approach to reduce the search space of possible text regions in an image. In order to improve the Text Proposals method we combined it with Fully Convolutional Networks to efficiently reduce the number of proposals while maintaining the same level of accuracy and thus gaining a significant speed up. Our experiments demonstrate that this text proposal approach yields significantly higher recall rates than the line based text localization techniques, while also producing better-quality localization. We have also applied this technique on compressed images such as videos from wearable egocentric cameras. For the task of word spotting, we have introduced a novel mid-level word representation method. We have proposed a technique to create and exploit an intermediate representation of images based on text attributes which roughly correspond to character probability maps. Our representation extends the concept of Pyramidal Histogram Of Characters (PHOC) by exploiting Fully Convolutional Networks to derive a pixel-wise mapping of the character distribution within candidate word regions. We call this representation the Soft-PHOC. Furthermore, we show how to use Soft-PHOC descriptors for word spotting tasks through an efficient text line proposal algorithm. To evaluate the detected text, we propose a novel line based evaluation along with the classic bounding box based approach. We test our method on incidental scene text images which comprises real-life scenarios such as urban scenes. The importance of incidental scene text images is due to the complexity of backgrounds, perspective, variety of script and language, short text and little linguistic context. All of these factors together makes the incidental scene text images challenging.