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Author Lluis Pere de las Heras; David Fernandez; Alicia Fornes; Ernest Valveny; Gemma Sanchez; Josep Llados
Title Runlength Histogram Image Signature for Perceptual Retrieval of Architectural Floor Plans Type Book Chapter
Year 2014 Publication Graphics Recognition. Current Trends and Challenges Abbreviated Journal
Volume 8746 Issue Pages 135-146
Keywords Graphics recognition; Graphics retrieval; Image classification
Abstract This paper proposes a runlength histogram signature as a perceptual descriptor of architectural plans in a retrieval scenario. The style of an architectural drawing is characterized by the perception of lines, shapes and texture. Such visual stimuli are the basis for defining semantic concepts as space properties, symmetry, density, etc. We propose runlength histograms extracted in vertical, horizontal and diagonal directions as a characterization of line and space properties in floorplans, so it can be roughly associated to a description of walls and room structure. A retrieval application illustrates the performance of the proposed approach, where given a plan as a query, similar ones are obtained from a database. A ground truth based on human observation has been constructed to validate the hypothesis. Additional retrieval results on sketched building’s facades are reported qualitatively in this paper. Its good description and its adaptability to two different sketch drawings despite its simplicity shows the interest of the proposed approach and opens a challenging research line in graphics recognition.
Address
Corporate Author Thesis
Publisher Springer Berlin Heidelberg Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title LNCS
Series Volume Series Issue Edition
ISSN 0302-9743 ISBN (up) 978-3-662-44853-3 Medium
Area Expedition Conference
Notes DAG; ADAS; 600.045; 600.056; 600.061; 600.076; 600.077 Approved no
Call Number Admin @ si @ HFF2014 Serial 2536
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Author Alicia Fornes; V.C.Kieu; M. Visani; N.Journet; Anjan Dutta
Title The ICDAR/GREC 2013 Music Scores Competition: Staff Removal Type Book Chapter
Year 2014 Publication Graphics Recognition. Current Trends and Challenges Abbreviated Journal
Volume 8746 Issue Pages 207-220
Keywords Competition; Graphics recognition; Music scores; Writer identification; Staff removal
Abstract The first competition on music scores that was organized at ICDAR and GREC in 2011 awoke the interest of researchers, who participated in both staff removal and writer identification tasks. In this second edition, we focus on the staff removal task and simulate a real case scenario concerning old and degraded music scores. For this purpose, we have generated a new set of semi-synthetic images using two degradation models that we previously introduced: local noise and 3D distortions. In this extended paper we provide an extended description of the dataset, degradation models, evaluation metrics, the participant’s methods and the obtained results that could not be presented at ICDAR and GREC proceedings due to page limitations.
Address
Corporate Author Thesis
Publisher Springer Berlin Heidelberg Place of Publication Editor B.Lamiroy; J.-M. Ogier
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title LNCS
Series Volume Series Issue Edition
ISSN 0302-9743 ISBN (up) 978-3-662-44853-3 Medium
Area Expedition Conference
Notes DAG; 600.077; 600.061 Approved no
Call Number Admin @ si @ FKV2014 Serial 2581
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Author Klaus Broelemann; Anjan Dutta; Xiaoyi Jiang; Josep Llados
Title Hierarchical Plausibility-Graphs for Symbol Spotting in Graphical Documents Type Book Chapter
Year 2014 Publication Graphics Recognition. Current Trends and Challenges Abbreviated Journal
Volume 8746 Issue Pages 25-37
Keywords
Abstract Graph representation of graphical documents often suffers from noise such as spurious nodes and edges, and their discontinuity. In general these errors occur during the low-level image processing viz. binarization, skeletonization, vectorization etc. Hierarchical graph representation is a nice and efficient way to solve this kind of problem by hierarchically merging node-node and node-edge depending on the distance. But the creation of hierarchical graph representing the graphical information often uses hard thresholds on the distance to create the hierarchical nodes (next state) of the lower nodes (or states) of a graph. As a result, the representation often loses useful information. This paper introduces plausibilities to the nodes of hierarchical graph as a function of distance and proposes a modified algorithm for matching subgraphs of the hierarchical graphs. The plausibility-annotated nodes help to improve the performance of the matching algorithm on two hierarchical structures. To show the potential of this approach, we conduct an experiment with the SESYD dataset.
Address
Corporate Author Thesis
Publisher Springer Berlin Heidelberg Place of Publication Editor Bart Lamiroy; Jean-Marc Ogier
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title LNCS
Series Volume Series Issue Edition
ISSN 0302-9743 ISBN (up) 978-3-662-44853-3 Medium
Area Expedition Conference
Notes DAG; 600.045; 600.056; 600.061; 600.077 Approved no
Call Number Admin @ si @ BDJ2014 Serial 2699
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Author Marçal Rusiñol; Dimosthenis Karatzas; Josep Llados
Title Spotting Graphical Symbols in Camera-Acquired Documents in Real Time Type Book Chapter
Year 2014 Publication Graphics Recognition. Current Trends and Challenges Abbreviated Journal
Volume 8746 Issue Pages 3-10
Keywords
Abstract In this paper we present a system devoted to spot graphical symbols in camera-acquired document images. The system is based on the extraction and further matching of ORB compact local features computed over interest key-points. Then, the FLANN indexing framework based on approximate nearest neighbor search allows to efficiently match local descriptors between the captured scene and the graphical models. Finally, the RANSAC algorithm is used in order to compute the homography between the spotted symbol and its appearance in the document image. The proposed approach is efficient and is able to work in real time.
Address
Corporate Author Thesis
Publisher Springer Berlin Heidelberg Place of Publication Editor Bart Lamiroy; Jean-Marc Ogier
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title LNCS
Series Volume Series Issue Edition
ISSN 0302-9743 ISBN (up) 978-3-662-44853-3 Medium
Area Expedition Conference
Notes DAG; 600.045; 600.055; 600.061; 600.077 Approved no
Call Number Admin @ si @ RKL2014 Serial 2700
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Author Marçal Rusiñol; V. Poulain d'Andecy; Dimosthenis Karatzas; Josep Llados
Title Classification of Administrative Document Images by Logo Identification Type Book Chapter
Year 2014 Publication Graphics Recognition. Current Trends and Challenges Abbreviated Journal
Volume 8746 Issue Pages 49-58
Keywords Administrative Document Classification; Logo Recognition; Logo Spotting
Abstract This paper is focused on the categorization of administrative document images (such as invoices) based on the recognition of the supplier’s graphical logo. Two different methods are proposed, the first one uses a bag-of-visual-words model whereas the second one tries to locate logo images described by the blurred shape model descriptor within documents by a sliding-window technique. Preliminar results are reported with a dataset of real administrative documents.
Address
Corporate Author Thesis
Publisher Springer Berlin Heidelberg Place of Publication Editor Bart Lamiroy; Jean-Marc Ogier
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0302-9743 ISBN (up) 978-3-662-44853-3 Medium
Area Expedition Conference
Notes DAG; 600.056; 600.045; 605.203; 600.077 Approved no
Call Number Admin @ si @ RPK2014 Serial 2701
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Author Michal Drozdzal
Title Sequential image analysis for computer-aided wireless endoscopy Type Book Whole
Year 2014 Publication PhD Thesis, Universitat de Barcelona-CVC Abbreviated Journal
Volume Issue Pages
Keywords
Abstract Wireless Capsule Endoscopy (WCE) is a technique for inner-visualization of the entire small intestine and, thus, offers an interesting perspective on intestinal motility. The two major drawbacks of this technique are: 1) huge amount of data acquired by WCE makes the motility analysis tedious and 2) since the capsule is the first tool that offers complete inner-visualization of the small intestine,the exact importance of the observed events is still an open issue. Therefore, in this thesis, a novel computer-aided system for intestinal motility analysis is presented. The goal of the system is to provide an easily-comprehensible visual description of motility-related intestinal events to a physician. In order to do so, several tools based either on computer vision concepts or on machine learning techniques are presented. A method for transforming 3D video signal to a holistic image of intestinal motility, called motility bar, is proposed. The method calculates the optimal mapping from video into image from the intestinal motility point of view.
To characterize intestinal motility, methods for automatic extraction of motility information from WCE are presented. Two of them are based on the motility bar and two of them are based on frame-per-frame analysis. In particular, four algorithms dealing with the problems of intestinal contraction detection, lumen size estimation, intestinal content characterization and wrinkle frame detection are proposed and validated. The results of the algorithms are converted into sequential features using an online statistical test. This test is designed to work with multivariate data streams. To this end, we propose a novel formulation of concentration inequality that is introduced into a robust adaptive windowing algorithm for multivariate data streams. The algorithm is used to obtain robust representation of segments with constant intestinal motility activity. The obtained sequential features are shown to be discriminative in the problem of abnormal motility characterization.
Finally, we tackle the problem of efficient labeling. To this end, we incorporate active learning concepts to the problems present in WCE data and propose two approaches. The first one is based the concepts of sequential learning and the second one adapts the partition-based active learning to an error-free labeling scheme. All these steps are sufficient to provide an extensive visual description of intestinal motility that can be used by an expert as decision support system.
Address
Corporate Author Thesis Ph.D. thesis
Publisher Ediciones Graficas Rey Place of Publication Editor Petia Radeva
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN (up) 978-84-940902-3-3 Medium
Area Expedition Conference
Notes MILAB Approved no
Call Number Admin @ si @ Dro2014 Serial 2486
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Author Anjan Dutta
Title Inexact Subgraph Matching Applied to Symbol Spotting in Graphical Documents Type Book Whole
Year 2014 Publication PhD Thesis, Universitat Autonoma de Barcelona-CVC Abbreviated Journal
Volume Issue Pages
Keywords
Abstract There is a resurgence in the use of structural approaches in the usual object recognition and retrieval problem. Graph theory, in particular, graph matching plays a relevant role in that. Specifically, the detection of an object (or a part of that) in an image in terms of structural features can be formulated as a subgraph matching. Subgraph matching is a challenging task. Specially due to the presence of outliers most of the graph matching algorithms do not perform well in subgraph matching scenario. Also exact subgraph isomorphism has proven to be an NP-complete problem. So naturally, in graph matching community, there are lot of efforts addressing the problem of subgraph matching within suboptimal bound. Most of them work with approximate algorithms that try to get an inexact solution in estimated way. In addition, usual recognition must cope with distortion. Inexact graph matching consists in finding the best isomorphism under a similarity measure. Theoretically this thesis proposes algorithms for solving subgraph matching in an approximate and inexact way.
We consider the symbol spotting problem on graphical documents or line drawings from application point of view. This is a well known problem in the graphics recognition community. It can be further applied for indexing and classification of documents based on their contents. The structural nature of this kind of documents easily motivates one for giving a graph based representation. So the symbol spotting problem on graphical documents can be considered as a subgraph matching problem. The main challenges in this application domain is the noise and distortions that might come during the usage, digitalization and raster to vector conversion of those documents. Apart from that computer vision nowadays is not any more confined within a limited number of images. So dealing a huge number of images with graph based method is a further challenge.
In this thesis, on one hand, we have worked on efficient and robust graph representation to cope with the noise and distortions coming from documents. On the other hand, we have worked on different graph based methods and framework to solve the subgraph matching problem in a better approximated way, which can also deal with considerable number of images. Firstly, we propose a symbol spotting method by hashing serialized subgraphs. Graph serialization allows to create factorized substructures such as graph paths, which can be organized in hash tables depending on the structural similarities of the serialized subgraphs. The involvement of hashing techniques helps to reduce the search space substantially and speeds up the spotting procedure. Secondly, we introduce contextual similarities based on the walk based propagation on tensor product graph. These contextual similarities involve higher order information and more reliable than pairwise similarities. We use these higher order similarities to formulate subgraph matching as a node and edge selection problem in the tensor product graph. Thirdly, we propose near convex grouping to form near convex region adjacency graph which eliminates the limitations of traditional region adjacency graph representation for graphic recognition. Fourthly, we propose a hierarchical graph representation by simplifying/correcting the structural errors to create a hierarchical graph of the base graph. Later these hierarchical graph structures are matched with some graph matching methods. Apart from that, in this thesis we have provided an overall experimental comparison of all the methods and some of the state-of-the-art methods. Furthermore, some dataset models have also been proposed.
Address
Corporate Author Thesis Ph.D. thesis
Publisher Ediciones Graficas Rey Place of Publication Editor Josep Llados;Umapada Pal
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN (up) 978-84-940902-4-0 Medium
Area Expedition Conference
Notes DAG; 600.077 Approved no
Call Number Admin @ si @ Dut2014 Serial 2465
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Author Monica Piñol
Title Reinforcement Learning of Visual Descriptors for Object Recognition Type Book Whole
Year 2014 Publication PhD Thesis, Universitat Autonoma de Barcelona-CVC Abbreviated Journal
Volume Issue Pages
Keywords
Abstract The human visual system is able to recognize the object in an image even if the object is partially occluded, from various points of view, in different colors, or with independence of the distance to the object. To do this, the eye obtains an image and extracts features that are sent to the brain, and then, in the brain the object is recognized. In computer vision, the object recognition branch tries to learns from the human visual system behaviour to achieve its goal. Hence, an algorithm is used to identify representative features of the scene (detection), then another algorithm is used to describe these points (descriptor) and finally the extracted information is used for classifying the object in the scene. The selection of this set of algorithms is a very complicated task and thus, a very active research field. In this thesis we are focused on the selection/learning of the best descriptor for a given image. In the state of the art there are several descriptors but we do not know how to choose the best descriptor because depends on scenes that we will use (dataset) and the algorithm chosen to do the classification. We propose a framework based on reinforcement learning and bag of features to choose the best descriptor according to the given image. The system can analyse the behaviour of different learning algorithms and descriptor sets. Furthermore the proposed framework for improving the classification/recognition ratio can be used with minor changes in other computer vision fields, such as video retrieval.
Address
Corporate Author Thesis Ph.D. thesis
Publisher Ediciones Graficas Rey Place of Publication Editor Ricardo Toledo;Angel Sappa
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN (up) 978-84-940902-5-7 Medium
Area Expedition Conference
Notes ADAS; 600.076 Approved no
Call Number Admin @ si @ Piñ2014 Serial 2464
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Author Antonio Clavelli
Title A computational model of eye guidance, searching for text in real scene images Type Book Whole
Year 2014 Publication PhD Thesis, Universitat Autonoma de Barcelona-CVC Abbreviated Journal
Volume Issue Pages
Keywords
Abstract Searching for text objects in real scene images is an open problem and a very active computer vision research area. A large number of methods have been proposed tackling the text search as extension of the ones from the document analysis field or inspired by general purpose object detection methods. However the general problem of object search in real scene images remains an extremely challenging problem due to the huge variability in object appearance. This thesis builds on top of the most recent findings in the visual attention literature presenting a novel computational model of eye guidance aiming to better describe text object search in real scene images.
First are presented the relevant state-of-the-art results from the visual attention literature regarding eye movements and visual search. Relevant models of attention are discussed and integrated with recent observations on the role of top-down constraints and the emerging need for a layered model of attention in which saliency is not the only factor guiding attention. Visual attention is then explained by the interaction of several modulating factors, such as objects, value, plans and saliency. Then we introduce our probabilistic formulation of attention deployment in real scene. The model is based on the rationale that oculomotor control depends on two interacting but distinct processes: an attentional process that assigns value to the sources of information and motor process that flexibly links information with action.
In such framework, the choice of where to look next is task-dependent and oriented to classes of objects embedded within pictures of complex scenes. The dependence on task is taken into account by exploiting the value and the reward of gazing at certain image patches or proto-objects that provide a sparse representation of the scene objects.
In the experimental section the model is tested in laboratory condition, comparing model simulations with data from eye tracking experiments. The comparison is qualitative in terms of observable scan paths and quantitative in terms of statistical similarity of gaze shift amplitude. Experiments are performed using eye tracking data from both a publicly available dataset of face and text and from newly performed eye-tracking experiments on a dataset of street view pictures containing text. The last part of this thesis is dedicated to study the extent to which the proposed model can account for human eye movements in a low constrained setting. We used a mobile eye tracking device and an ad-hoc developed methodology to compare model simulated eye data with the human eye data from mobile eye tracking recordings. Such setting allow to test the model in an incomplete visual information condition, reproducing a close to real-life search task.
Address
Corporate Author Thesis Ph.D. thesis
Publisher Ediciones Graficas Rey Place of Publication Editor Dimosthenis Karatzas;Giuseppe Boccignone;Josep Llados
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN (up) 978-84-940902-6-4 Medium
Area Expedition Conference
Notes DAG; 600.077 Approved no
Call Number Admin @ si @ Cla2014 Serial 2571
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Author David Fernandez
Title Contextual Word Spotting in Historical Handwritten Documents Type Book Whole
Year 2014 Publication PhD Thesis, Universitat Autonoma de Barcelona-CVC Abbreviated Journal
Volume Issue Pages
Keywords
Abstract There are countless collections of historical documents in archives and libraries that contain plenty of valuable information for historians and researchers. The extraction of this information has become a central task among the Document Analysis researches and practitioners.
There is an increasing interest to digital preserve and provide access to these kind of documents. But only the digitalization is not enough for the researchers. The extraction and/or indexation of information of this documents has had an increased interest among researchers. In many cases, and in particular in historical manuscripts, the full transcription of these documents is extremely dicult due the inherent de ciencies: poor physical preservation, di erent writing styles, obsolete languages, etc. Word spotting has become a popular an ecient alternative to full transcription. It inherently involves a high level of degradation in the images. The search of words is holistically
formulated as a visual search of a given query shape in a larger image, instead of recognising the input text and searching the query word with an ascii string comparison. But the performance of classical word spotting approaches depend on the degradation level of the images being unacceptable in many cases . In this thesis we have proposed a novel paradigm called contextual word spotting method that uses the contextual/semantic information to achieve acceptable results whereas classical word spotting does not reach. The contextual word spotting framework proposed in this thesis is a segmentation-based word spotting approach, so an ecient word segmentation is needed. Historical handwritten
documents present some common diculties that can increase the diculties the extraction of the words. We have proposed a line segmentation approach that formulates the problem as nding the central part path in the area between two consecutive lines. This is solved as a graph traversal problem. A path nding algorithm is used to nd the optimal path in a graph, previously computed, between the text lines. Once the text lines are extracted, words are localized inside the text lines using a word segmentation technique from the state of the
art. Classical word spotting approaches can be improved using the contextual information of the documents. We have introduced a new framework, oriented to handwritten documents that present a highly structure, to extract information making use of context. The framework is an ecient tool for semi-automatic transcription that uses the contextual information to achieve better results than classical word spotting approaches. The contextual information is
automatically discovered by recognizing repetitive structures and categorizing all the words according to semantic classes. The most frequent words in each semantic cluster are extracted and the same text is used to transcribe all them. The experimental results achieved in this thesis outperform classical word spotting approaches demonstrating the suitability of the proposed ensemble architecture for spotting words in historical handwritten documents using contextual information.
Address
Corporate Author Thesis Ph.D. thesis
Publisher Ediciones Graficas Rey Place of Publication Editor Josep Llados;Alicia Fornes
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN (up) 978-84-940902-7-1 Medium
Area Expedition Conference
Notes DAG; 600.077 Approved no
Call Number Admin @ si @ Fer2014 Serial 2573
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Author Lluis Pere de las Heras
Title Relational Models for Visual Understanding of Graphical Documents. Application to Architectural Drawings. Type Book Whole
Year 2014 Publication PhD Thesis, Universitat Autonoma de Barcelona-CVC Abbreviated Journal
Volume Issue Pages
Keywords
Abstract Graphical documents express complex concepts using a visual language. This language consists of a vocabulary (symbols) and a syntax (structural relations between symbols) that articulate a semantic meaning in a certain context. Therefore, the automatic interpretation by computers of these sort of documents entails three main steps: the detection of the symbols, the extraction of the structural relations between these symbols, and the modeling of the knowledge that permits the extraction of the semantics. Di erent domains in graphical documents include: architectural and engineering drawings, maps, owcharts, etc.
Graphics Recognition in particular and Document Image Analysis in general are
born from the industrial need of interpreting a massive amount of digitalized documents after the emergence of the scanner. Although many years have passed, the graphical document understanding problem still seems to be far from being solved. The main reason is that the vast majority of the systems in the literature focus on very speci c problems, where the domain of the document dictates the implementation of the interpretation. As a result, it is dicult to reuse these strategies on di erent data and on di erent contexts, hindering thus the natural progress in the eld.
In this thesis, we face the graphical document understanding problem by proposing several relational models at di erent levels that are designed from a generic perspective. Firstly, we introduce three di erent strategies for the detection of symbols. The fi rst method tackles the problem structurally, wherein general knowledge of the domain guides the detection. The second is a statistical method that learns the graphical appearance of the symbols and easily adapts to the big variability of the problem. The third method is a combination of the previous two methods that inherits their respective strengths, i.e. copes the big variability and does not need annotated data. Secondly, we present two relational strategies that tackle the problem of the visual context extraction. The fi rst one is a full bottom up method that heuristically searches in a graph representation the contextual relations between symbols. Contrarily, the second is syntactic method that models probabilistically the structure of the documents. It automatically learns the model, which guides the inference algorithm to encounter the best structural representation for a given input. Finally, we construct a knowledge-based model consisting of an ontological de nition of the domain and real data. This model permits to perform contextual reasoning and to detect semantic inconsistencies within the data. We evaluate the suitability of the proposed contributions in the framework of floor plan interpretation. Since there is no standard in the modeling of these documents there exists an enormous notation variability from plan to plan in terms of vocabulary and syntax. Therefore, floor plan interpretation is a relevant task in the graphical document understanding problem. It is also worth to mention that we make freely available all the resources used in this thesis {the data, the tool used to generate the data, and the evaluation scripts{ with the aim of fostering research in the graphical document understanding task.
Address
Corporate Author Thesis Ph.D. thesis
Publisher Ediciones Graficas Rey Place of Publication Editor Gemma Sanchez
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN (up) 978-84-940902-8-8 Medium
Area Expedition Conference
Notes DAG; 600.077 Approved no
Call Number Admin @ si @ Her2014 Serial 2574
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Author Carles Sanchez
Title Tracheal Structure Characterization using Geometric and Appearance Models for Efficient Assessment of Stenosis in Videobronchoscopy Type Book Whole
Year 2014 Publication PhD Thesis, Universitat Autonoma de Barcelona-CVC Abbreviated Journal
Volume Issue Pages
Keywords
Abstract Recent advances in endoscopic devices have increased their use for minimal invasive diagnostic and intervention procedures. Among all endoscopic modalities, bronchoscopy is one of the most frequent with around 261 millions of procedures per year. Although the use of bronchoscopy is spread among clinical facilities it presents some drawbacks, being the visual inspection for the assessment of anatomical measurements the most prevalent of them. In
particular, inaccuracies in the estimation of the degree of stenosis (the percentage of obstructed airway) decreases its diagnostic yield and might lead to erroneous treatments. An objective computation of tracheal stenosis in bronchoscopy videos would constitute a breakthrough for this non-invasive technique and a reduction in treatment cost.
This thesis settles the first steps towards on-line reliable extraction of anatomical information from videobronchoscopy for computation of objective measures. In particular, we focus on the computation of the degree of stenosis, which is obtained by comparing the area delimited by a healthy tracheal ring and the stenosed lumen. Reliable extraction of airway structures in interventional videobronchoscopy is a challenging task. This is mainly due to the large variety of acquisition conditions (positions and illumination), devices (different digitalizations) and in videos acquired at the operating room the unpredicted presence of surgical devices (such as probe ends). This thesis contributes to on-line stenosis assessment in several ways. We
propose a parametric strategy for the extraction of lumen and tracheal rings regions based on the characterization of their geometry and appearance that guide a deformable model. The geometric and appearance characterization is based on a physical model describing the way bronchoscopy images are obtained and includes local and global descriptions. In order to ensure a systematic applicability we present a statistical framework to select the optimal
parameters of our method. Experiments perform on the first public annotated database, show that the performance of our method is comparable to the one provided by clinicians and its computation time allows for a on-line implementation in the operating room.
Address
Corporate Author Thesis Ph.D. thesis
Publisher Ediciones Graficas Rey Place of Publication Editor F. Javier Sanchez;Debora Gil;Jorge Bernal
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN (up) 978-84-940902-9-5 Medium
Area Expedition Conference
Notes IAM; 600.075 Approved no
Call Number Admin @ si @ San2014 Serial 2575
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Author David Roche; Debora Gil; Jesus Giraldo
Title Mathematical modeling of G protein-coupled receptor function: What can we learn from empirical and mechanistic models? Type Book Chapter
Year 2014 Publication G Protein-Coupled Receptors – Modeling and Simulation Advances in Experimental Medicine and Biology Abbreviated Journal
Volume 796 Issue 3 Pages 159-181
Keywords β-arrestin; biased agonism; curve fitting; empirical modeling; evolutionary algorithm; functional selectivity; G protein; GPCR; Hill coefficient; intrinsic efficacy; inverse agonism; mathematical modeling; mechanistic modeling; operational model; parameter optimization; receptor dimer; receptor oligomerization; receptor constitutive activity; signal transduction; two-state model
Abstract Empirical and mechanistic models differ in their approaches to the analysis of pharmacological effect. Whereas the parameters of the former are not physical constants those of the latter embody the nature, often complex, of biology. Empirical models are exclusively used for curve fitting, merely to characterize the shape of the E/[A] curves. Mechanistic models, on the contrary, enable the examination of mechanistic hypotheses by parameter simulation. Regretfully, the many parameters that mechanistic models may include can represent a great difficulty for curve fitting, representing, thus, a challenge for computational method development. In the present study some empirical and mechanistic models are shown and the connections, which may appear in a number of cases between them, are analyzed from the curves they yield. It may be concluded that systematic and careful curve shape analysis can be extremely useful for the understanding of receptor function, ligand classification and drug discovery, thus providing a common language for the communication between pharmacologists and medicinal chemists.
Address
Corporate Author Thesis
Publisher Springer Netherlands Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0065-2598 ISBN (up) 978-94-007-7422-3 Medium
Area Expedition Conference
Notes IAM; 600.075 Approved no
Call Number IAM @ iam @ RGG2014 Serial 2197
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